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Unconditional two-locus nonparametric linkage analysis

Ängquist, Lars LU ; Anevski, Dragi LU and Luthman, Holger LU (2005) In Preprint without journal information
Abstract
We discuss different aspects of unconditional two-locus nonparametric linkage (NPL) analysis with special emphasis on gene-gene interaction. We interpret this as identical-by-descent (IBD) sharing correlation between two disease loci both having marginal effect. We relate this to the concept of two-locus NPL score functions, the possible importance of using a composite rather than a simple null hypothesis and the corresponding calculation of statistical power. Moreover, we define several classes of score functions and give multiple suggestions on how to incorporate a composite null hypothesis into the analysis. The least favourable two-locus IBD-distribution is discussed, resulting in an upper bound of the two-locus p-value.
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author
; and
organization
publishing date
type
Contribution to journal
publication status
unpublished
subject
in
Preprint without journal information
issue
2005:28
publisher
Manne Siegbahn Institute
ISSN
0348-7911
language
English
LU publication?
yes
id
aa7b630b-0a69-418f-9ee2-cbdc39c3491f (old id 930229)
date added to LUP
2016-04-04 09:11:24
date last changed
2018-11-21 20:51:23
@article{aa7b630b-0a69-418f-9ee2-cbdc39c3491f,
  abstract     = {{We discuss different aspects of unconditional two-locus nonparametric linkage (NPL) analysis with special emphasis on gene-gene interaction. We interpret this as identical-by-descent (IBD) sharing correlation between two disease loci both having marginal effect. We relate this to the concept of two-locus NPL score functions, the possible importance of using a composite rather than a simple null hypothesis and the corresponding calculation of statistical power. Moreover, we define several classes of score functions and give multiple suggestions on how to incorporate a composite null hypothesis into the analysis. The least favourable two-locus IBD-distribution is discussed, resulting in an upper bound of the two-locus p-value.}},
  author       = {{Ängquist, Lars and Anevski, Dragi and Luthman, Holger}},
  issn         = {{0348-7911}},
  language     = {{eng}},
  number       = {{2005:28}},
  publisher    = {{Manne Siegbahn Institute}},
  series       = {{Preprint without journal information}},
  title        = {{Unconditional two-locus nonparametric linkage analysis}},
  year         = {{2005}},
}