The theragnostic potential of polyaniline-decorated magnetic nanoparticles: a sorafenib carrier for chemo-photothermal therapy and imaging of hepatocellular carcinoma
(2025) In Journal of Drug Delivery Science and Technology 113.- Abstract
- In recent years, researchers have extensively investigated hepatocellular carcinoma (HCC), a prevalent cancer type worldwide. Its resistance to conventional treatments highlights the promise of theragnostic nanoparticles, offering multiple tools within a single platform for fighting HCC cells. In this research, using polyaniline (PANI)-coated cobalt ferrite nanoparticles (CFO), an innovative nanocomposite system has been developed for drug delivery, photothermal therapy, and magnetic resonance imaging (MRI) of HCC. The composite nanoparticles were fabricated by a facile co-precipitation synthesis, and PANI chains were formed on the surface through the chemical oxidative polymerization of aniline monomer. Physicochemical characteristics of... (More)
- In recent years, researchers have extensively investigated hepatocellular carcinoma (HCC), a prevalent cancer type worldwide. Its resistance to conventional treatments highlights the promise of theragnostic nanoparticles, offering multiple tools within a single platform for fighting HCC cells. In this research, using polyaniline (PANI)-coated cobalt ferrite nanoparticles (CFO), an innovative nanocomposite system has been developed for drug delivery, photothermal therapy, and magnetic resonance imaging (MRI) of HCC. The composite nanoparticles were fabricated by a facile co-precipitation synthesis, and PANI chains were formed on the surface through the chemical oxidative polymerization of aniline monomer. Physicochemical characteristics of nanoparticles were evaluated using FESEM, HRTEM, FTIR, XRD, TGA, VSM, DLS, and Zeta potential analyses. PANI acted as a pH-sensitive component for the controlled release of sorafenib (SB) chemo-drug with a loading capacity of 6.21 %. In response to NIR radiation, the nanocomposite raised its medium temperature to 55 °C. Further, the nanoplatform's relaxivity was 32.61 mM−1 S−1, enabling it to be used for MRI contrast. Meanwhile, hemolysis tests indicated acceptable hemocompatibility of 680 g/ml. While in vitro flow cytometry tests revealed no detrimental effects on the viability of HepG2 cancer cells by the nanocomposite, the SB-loaded nanocomposite exhibited significant toxicity toward these cells. This suggests that the nanocarrier enhances SB's therapeutic efficacy. Overall, the developed nanoplatform demonstrates strong photothermal conversion, effective MRI contrast properties, and good drug-loading capacity, making it a promising candidate for cancer theragnostic. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/aa855447-d7a2-4d53-b454-c23eb0634cab
- author
- Pourhossein, Mohammad LU ; Pishbin, Fatemehsadat ; Ataie, Abolghasem ; Akrami, Mohammad and Mostafavi, Ebrahim
- publishing date
- 2025-07-19
- type
- Contribution to journal
- publication status
- published
- keywords
- Magnetic nanocomposite, Drug delivery, Photothermal therapy, Magnetic resonance imaging, ancer theragnostic
- in
- Journal of Drug Delivery Science and Technology
- volume
- 113
- publisher
- Editions de Sante
- external identifiers
-
- scopus:105011521858
- ISSN
- 1773-2247
- DOI
- 10.1016/j.jddst.2025.107307
- language
- English
- LU publication?
- no
- id
- aa855447-d7a2-4d53-b454-c23eb0634cab
- date added to LUP
- 2025-08-01 11:29:51
- date last changed
- 2025-08-07 09:43:07
@article{aa855447-d7a2-4d53-b454-c23eb0634cab,
abstract = {{In recent years, researchers have extensively investigated hepatocellular carcinoma (HCC), a prevalent cancer type worldwide. Its resistance to conventional treatments highlights the promise of theragnostic nanoparticles, offering multiple tools within a single platform for fighting HCC cells. In this research, using polyaniline (PANI)-coated cobalt ferrite nanoparticles (CFO), an innovative nanocomposite system has been developed for drug delivery, photothermal therapy, and magnetic resonance imaging (MRI) of HCC. The composite nanoparticles were fabricated by a facile co-precipitation synthesis, and PANI chains were formed on the surface through the chemical oxidative polymerization of aniline monomer. Physicochemical characteristics of nanoparticles were evaluated using FESEM, HRTEM, FTIR, XRD, TGA, VSM, DLS, and Zeta potential analyses. PANI acted as a pH-sensitive component for the controlled release of sorafenib (SB) chemo-drug with a loading capacity of 6.21 %. In response to NIR radiation, the nanocomposite raised its medium temperature to 55 °C. Further, the nanoplatform's relaxivity was 32.61 mM−1 S−1, enabling it to be used for MRI contrast. Meanwhile, hemolysis tests indicated acceptable hemocompatibility of 680 g/ml. While in vitro flow cytometry tests revealed no detrimental effects on the viability of HepG2 cancer cells by the nanocomposite, the SB-loaded nanocomposite exhibited significant toxicity toward these cells. This suggests that the nanocarrier enhances SB's therapeutic efficacy. Overall, the developed nanoplatform demonstrates strong photothermal conversion, effective MRI contrast properties, and good drug-loading capacity, making it a promising candidate for cancer theragnostic.}},
author = {{Pourhossein, Mohammad and Pishbin, Fatemehsadat and Ataie, Abolghasem and Akrami, Mohammad and Mostafavi, Ebrahim}},
issn = {{1773-2247}},
keywords = {{Magnetic nanocomposite; Drug delivery; Photothermal therapy; Magnetic resonance imaging; ancer theragnostic}},
language = {{eng}},
month = {{07}},
publisher = {{Editions de Sante}},
series = {{Journal of Drug Delivery Science and Technology}},
title = {{The theragnostic potential of polyaniline-decorated magnetic nanoparticles: a sorafenib carrier for chemo-photothermal therapy and imaging of hepatocellular carcinoma}},
url = {{http://dx.doi.org/10.1016/j.jddst.2025.107307}},
doi = {{10.1016/j.jddst.2025.107307}},
volume = {{113}},
year = {{2025}},
}