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Perinatal events and the risk of developing primary sclerosing cholangitis

Bergquist, Annika; Montgomery, Scott M.; Lund, Ulrika; Ekbom, Anders; Olsson, Rolf; Lindgren, Stefan LU ; Prytz, Hanne LU ; Hultcrantz, Rolf and Broome, Ulrika (2006) In World Journal of Gastroenterology 12(37). p.6037-6040
Abstract
AIM: To investigate whether perinatal events, intrauterine or postpartum, are associated with the development of primary sclerosing cholangitis (PSC) later in life. METHODS: Birth records from 97 patients with adult PSC in Sweden were reviewed. Information on perinatal events including medications and complications during pregnancy, gestation length, birth weight and length were collected. Two control children of the same sex were selected for each subject. Conditional multiple logistic regression was used to assess associations of the perinatal measures with development of PSC. RESULTS: No significant associations were found between gestational age, birth length, breastfeeding, and the majority of medical complications including... (More)
AIM: To investigate whether perinatal events, intrauterine or postpartum, are associated with the development of primary sclerosing cholangitis (PSC) later in life. METHODS: Birth records from 97 patients with adult PSC in Sweden were reviewed. Information on perinatal events including medications and complications during pregnancy, gestation length, birth weight and length were collected. Two control children of the same sex were selected for each subject. Conditional multiple logistic regression was used to assess associations of the perinatal measures with development of PSC. RESULTS: No significant associations were found between gestational age, birth length, breastfeeding, and the majority of medical complications including infections or medication during pregnancy for the mothers or postpartum for the children. Vaginal bleeding and peripheral oedema showed associations with PSC, with matched odds ratios of 5.70 (95% CI, 1.13-28.83) and 2.28 (95% CI, 1.04-5.03), respectively. CONCLUSION: The associations of vaginal bleeding and oedema with subsequent PSC cannot readily be explained, so our findings do not strongly support the hypothesis of a significant role of perinatal events as a risk for the development of PSC later in life. (C) 2006 The WJG Press. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
inflammatory bowel disease, perinatal factors, sclerosing cholangitis
in
World Journal of Gastroenterology
volume
12
issue
37
pages
6037 - 6040
publisher
WJG Press
external identifiers
  • wos:000241216400018
  • scopus:33750275750
ISSN
1007-9327
language
English
LU publication?
yes
id
aaabfbba-804f-4130-bc1d-0d5e97e8623a (old id 388276)
alternative location
http://www.wjgnet.com/1007-9327/12/6037.asp
date added to LUP
2007-09-28 10:10:19
date last changed
2019-02-20 04:36:48
@article{aaabfbba-804f-4130-bc1d-0d5e97e8623a,
  abstract     = {AIM: To investigate whether perinatal events, intrauterine or postpartum, are associated with the development of primary sclerosing cholangitis (PSC) later in life. METHODS: Birth records from 97 patients with adult PSC in Sweden were reviewed. Information on perinatal events including medications and complications during pregnancy, gestation length, birth weight and length were collected. Two control children of the same sex were selected for each subject. Conditional multiple logistic regression was used to assess associations of the perinatal measures with development of PSC. RESULTS: No significant associations were found between gestational age, birth length, breastfeeding, and the majority of medical complications including infections or medication during pregnancy for the mothers or postpartum for the children. Vaginal bleeding and peripheral oedema showed associations with PSC, with matched odds ratios of 5.70 (95% CI, 1.13-28.83) and 2.28 (95% CI, 1.04-5.03), respectively. CONCLUSION: The associations of vaginal bleeding and oedema with subsequent PSC cannot readily be explained, so our findings do not strongly support the hypothesis of a significant role of perinatal events as a risk for the development of PSC later in life. (C) 2006 The WJG Press. All rights reserved.},
  author       = {Bergquist, Annika and Montgomery, Scott M. and Lund, Ulrika and Ekbom, Anders and Olsson, Rolf and Lindgren, Stefan and Prytz, Hanne and Hultcrantz, Rolf and Broome, Ulrika},
  issn         = {1007-9327},
  keyword      = {inflammatory bowel disease,perinatal factors,sclerosing cholangitis},
  language     = {eng},
  number       = {37},
  pages        = {6037--6040},
  publisher    = {WJG Press},
  series       = {World Journal of Gastroenterology},
  title        = {Perinatal events and the risk of developing primary sclerosing cholangitis},
  volume       = {12},
  year         = {2006},
}