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The relation between survival and expression of HER1 and HER2 depends on the expression of HER3 and HER4 : a study in bladder cancer patients

Memon, A A LU orcid ; Sorensen, B S ; Meldgaard, P ; Fokdal, L ; Thykjaer, T and Nexo, E (2006) In British Journal of Cancer 94(11). p.9-1703
Abstract

Increased expression of the epidermal growth factor (EGF) receptors, HER1 and HER2 are related to poor prognosis in most cancers studied. Recently, a high expression of the two remaining receptors of the EGF system, HER3 and HER4 has been related to a favourable prognosis. However, prognostic significance of HER1 and HER2 receptors in bladder cancer is controversial and the effect of the expression of different combinations of these receptors on patient survival is not well understood. Therefore, we examined the mRNA expression of all four EGF receptors with real-time polymerase chain reaction in biopsies from 88 patients with bladder cancer, where the survival was followed for a median of 38.5 months (range 1-117 months). Expression of... (More)

Increased expression of the epidermal growth factor (EGF) receptors, HER1 and HER2 are related to poor prognosis in most cancers studied. Recently, a high expression of the two remaining receptors of the EGF system, HER3 and HER4 has been related to a favourable prognosis. However, prognostic significance of HER1 and HER2 receptors in bladder cancer is controversial and the effect of the expression of different combinations of these receptors on patient survival is not well understood. Therefore, we examined the mRNA expression of all four EGF receptors with real-time polymerase chain reaction in biopsies from 88 patients with bladder cancer, where the survival was followed for a median of 38.5 months (range 1-117 months). Expression of HER1 and HER2 alone showed no correlation with survival. However, a high expression of HER1 together with high expression of HER3 and HER4 correlated to a better prognosis compared to the high expression of HER1 together with low expression of HER3 and HER4 (P=0.0006). Also, a significantly longer survival was observed in patients expressing high HER2 when coexpressed with high HER3 and HER4, as compared to the survival in patients with tumours expressing high HER2 but low HER3 and HER4 (P=0.0005). Our results suggest that the final outcome of patients with high HER1- and HER2-expressing tumours depends on the expression of HER3 and HER4.

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author
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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aged, Aged, 80 and over, Base Sequence, DNA Primers, ErbB Receptors/genetics, Female, Humans, Male, Middle Aged, Prognosis, RNA, Messenger/genetics, RNA, Neoplasm/genetics, Receptor, ErbB-2/genetics, Receptor, ErbB-3/genetics, Receptor, ErbB-4, Survival Analysis, Urinary Bladder Neoplasms/genetics
in
British Journal of Cancer
volume
94
issue
11
pages
7 pages
publisher
Nature Publishing Group
external identifiers
  • pmid:16685269
  • scopus:33745272244
ISSN
0007-0920
DOI
10.1038/sj.bjc.6603154
language
English
LU publication?
no
id
aaae29d7-23f5-4ee3-a419-867797666c49
date added to LUP
2019-11-22 16:19:17
date last changed
2024-05-29 04:16:04
@article{aaae29d7-23f5-4ee3-a419-867797666c49,
  abstract     = {{<p>Increased expression of the epidermal growth factor (EGF) receptors, HER1 and HER2 are related to poor prognosis in most cancers studied. Recently, a high expression of the two remaining receptors of the EGF system, HER3 and HER4 has been related to a favourable prognosis. However, prognostic significance of HER1 and HER2 receptors in bladder cancer is controversial and the effect of the expression of different combinations of these receptors on patient survival is not well understood. Therefore, we examined the mRNA expression of all four EGF receptors with real-time polymerase chain reaction in biopsies from 88 patients with bladder cancer, where the survival was followed for a median of 38.5 months (range 1-117 months). Expression of HER1 and HER2 alone showed no correlation with survival. However, a high expression of HER1 together with high expression of HER3 and HER4 correlated to a better prognosis compared to the high expression of HER1 together with low expression of HER3 and HER4 (P=0.0006). Also, a significantly longer survival was observed in patients expressing high HER2 when coexpressed with high HER3 and HER4, as compared to the survival in patients with tumours expressing high HER2 but low HER3 and HER4 (P=0.0005). Our results suggest that the final outcome of patients with high HER1- and HER2-expressing tumours depends on the expression of HER3 and HER4.</p>}},
  author       = {{Memon, A A and Sorensen, B S and Meldgaard, P and Fokdal, L and Thykjaer, T and Nexo, E}},
  issn         = {{0007-0920}},
  keywords     = {{Aged; Aged, 80 and over; Base Sequence; DNA Primers; ErbB Receptors/genetics; Female; Humans; Male; Middle Aged; Prognosis; RNA, Messenger/genetics; RNA, Neoplasm/genetics; Receptor, ErbB-2/genetics; Receptor, ErbB-3/genetics; Receptor, ErbB-4; Survival Analysis; Urinary Bladder Neoplasms/genetics}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{11}},
  pages        = {{9--1703}},
  publisher    = {{Nature Publishing Group}},
  series       = {{British Journal of Cancer}},
  title        = {{The relation between survival and expression of HER1 and HER2 depends on the expression of HER3 and HER4 : a study in bladder cancer patients}},
  url          = {{http://dx.doi.org/10.1038/sj.bjc.6603154}},
  doi          = {{10.1038/sj.bjc.6603154}},
  volume       = {{94}},
  year         = {{2006}},
}