Effects of propofol on isolated human pial arteries
(1999) In Acta Anaesthesiologica Scandinavica 43(10). p.1065-1068- Abstract
- BACKGROUND: The intravenous anaesthetic propofol has been reported to increase cerebral vascular resistance in vivo. The underlying mechanisms are not fully understood, but may include effects on metabolism and direct effects on the vascular smooth muscle. The present study was designed to evaluate the direct effects of propofol on human pial arteries. METHODS: We investigated the direct effect of propofol (10(-6)-10(-4) M) on isolated human pial arteries at basal tension as well as the influence on contractions induced by 5-hydroxytryptamine, prostaglandin F2alpha, noradrenaline and potassium chloride. RESULTS: Propofol did not change the basal tension. Propofol at 10(-6) and 10(-5) M did not affect the concentration-response curves of... (More)
- BACKGROUND: The intravenous anaesthetic propofol has been reported to increase cerebral vascular resistance in vivo. The underlying mechanisms are not fully understood, but may include effects on metabolism and direct effects on the vascular smooth muscle. The present study was designed to evaluate the direct effects of propofol on human pial arteries. METHODS: We investigated the direct effect of propofol (10(-6)-10(-4) M) on isolated human pial arteries at basal tension as well as the influence on contractions induced by 5-hydroxytryptamine, prostaglandin F2alpha, noradrenaline and potassium chloride. RESULTS: Propofol did not change the basal tension. Propofol at 10(-6) and 10(-5) M did not affect the concentration-response curves of any of the contractile agents tested. Propofol at the supraclinical concentration 10(-4) M reduced the contractions induced by all contractile agents. CONCLUSION: Propofol reduces the tone of human pial arteries in vitro at supraclinical concentrations, but has no effect on the tone at clinically relevant concentrations. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1114905
- author
- Wallerstedt, S M ; Reinstrup, Peter LU ; Uski, Tore LU and Bodelsson, Mikael LU
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Anesthetic, intravenous, propofol, human, cerebral arteries
- in
- Acta Anaesthesiologica Scandinavica
- volume
- 43
- issue
- 10
- pages
- 1065 - 1068
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:10593473
- scopus:0032723587
- ISSN
- 0001-5172
- DOI
- 10.1034/j.1399-6576.1999.431017.x
- language
- English
- LU publication?
- yes
- id
- aab63215-46e0-46f4-b33c-79902e4fef98 (old id 1114905)
- alternative location
- http://www3.interscience.wiley.com/cgi-bin/fulltext/119055116/PDFSTART
- date added to LUP
- 2016-04-01 11:36:56
- date last changed
- 2022-01-26 07:37:35
@article{aab63215-46e0-46f4-b33c-79902e4fef98, abstract = {{BACKGROUND: The intravenous anaesthetic propofol has been reported to increase cerebral vascular resistance in vivo. The underlying mechanisms are not fully understood, but may include effects on metabolism and direct effects on the vascular smooth muscle. The present study was designed to evaluate the direct effects of propofol on human pial arteries. METHODS: We investigated the direct effect of propofol (10(-6)-10(-4) M) on isolated human pial arteries at basal tension as well as the influence on contractions induced by 5-hydroxytryptamine, prostaglandin F2alpha, noradrenaline and potassium chloride. RESULTS: Propofol did not change the basal tension. Propofol at 10(-6) and 10(-5) M did not affect the concentration-response curves of any of the contractile agents tested. Propofol at the supraclinical concentration 10(-4) M reduced the contractions induced by all contractile agents. CONCLUSION: Propofol reduces the tone of human pial arteries in vitro at supraclinical concentrations, but has no effect on the tone at clinically relevant concentrations.}}, author = {{Wallerstedt, S M and Reinstrup, Peter and Uski, Tore and Bodelsson, Mikael}}, issn = {{0001-5172}}, keywords = {{Anesthetic; intravenous; propofol; human; cerebral arteries}}, language = {{eng}}, number = {{10}}, pages = {{1065--1068}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Anaesthesiologica Scandinavica}}, title = {{Effects of propofol on isolated human pial arteries}}, url = {{http://dx.doi.org/10.1034/j.1399-6576.1999.431017.x}}, doi = {{10.1034/j.1399-6576.1999.431017.x}}, volume = {{43}}, year = {{1999}}, }