Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes
Markholst, Helle ; Eastman, Susan ; Wilson, Deborah ; Andreasen, Bodil E. and Lernmark, Åke LU
(1991)
In Journal of Experimental Medicine
174(1).
p.297-300
- Abstract
Diabetes-prone (DP) BB rats spontaneously develop insulin-dependent diabetes resembling type 1 diabetes mellitus in man. They also exhibit lifelong T cell deficiency. The segregation of both diabetes and lymphopenia was studied in crosses between this inbred line of rats and the related but nondiabetic and nonlymphopenic inbred diabetes-resistant (DR) BB rat line. Diabetes segregated as a single, autosomal recessive trait and was always accompanied by lymphopenia. Among the limited number ofdifferences in the genomic DNA sequences of the two lines, DP and DR BB, one may account for the development of diabetes and lymphopenia in the DP BB rats. It may be possible to screen the genomic DNA for such differences to detect a marker for... (More)
Diabetes-prone (DP) BB rats spontaneously develop insulin-dependent diabetes resembling type 1 diabetes mellitus in man. They also exhibit lifelong T cell deficiency. The segregation of both diabetes and lymphopenia was studied in crosses between this inbred line of rats and the related but nondiabetic and nonlymphopenic inbred diabetes-resistant (DR) BB rat line. Diabetes segregated as a single, autosomal recessive trait and was always accompanied by lymphopenia. Among the limited number ofdifferences in the genomic DNA sequences of the two lines, DP and DR BB, one may account for the development of diabetes and lymphopenia in the DP BB rats. It may be possible to screen the genomic DNA for such differences to detect a marker for thephenotypes.
(Less)
- author
- Markholst, Helle
; Eastman, Susan
; Wilson, Deborah
; Andreasen, Bodil E.
and Lernmark, Åke
LU
- publishing date
- 1991-07-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Experimental Medicine
- volume
- 174
- issue
- 1
- pages
- 4 pages
- publisher
- Rockefeller University Press
- external identifiers
-
- scopus:0025735426
- pmid:2056281
- ISSN
- 0022-1007
- DOI
- 10.1084/jem.174.1.297
- language
- English
- LU publication?
- no
- id
- aad87583-ea3a-4185-8cfb-beb99b8ee446
- date added to LUP
- 2019-09-11 09:41:20
- date last changed
- 2024-03-13 08:22:37
@article{aad87583-ea3a-4185-8cfb-beb99b8ee446,
abstract = {{<p>Diabetes-prone (DP) BB rats spontaneously develop insulin-dependent diabetes resembling type 1 diabetes mellitus in man. They also exhibit lifelong T cell deficiency. The segregation of both diabetes and lymphopenia was studied in crosses between this inbred line of rats and the related but nondiabetic and nonlymphopenic inbred diabetes-resistant (DR) BB rat line. Diabetes segregated as a single, autosomal recessive trait and was always accompanied by lymphopenia. Among the limited number ofdifferences in the genomic DNA sequences of the two lines, DP and DR BB, one may account for the development of diabetes and lymphopenia in the DP BB rats. It may be possible to screen the genomic DNA for such differences to detect a marker for thephenotypes.</p>}},
author = {{Markholst, Helle and Eastman, Susan and Wilson, Deborah and Andreasen, Bodil E. and Lernmark, Åke}},
issn = {{0022-1007}},
language = {{eng}},
month = {{07}},
number = {{1}},
pages = {{297--300}},
publisher = {{Rockefeller University Press}},
series = {{Journal of Experimental Medicine}},
title = {{Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes}},
url = {{http://dx.doi.org/10.1084/jem.174.1.297}},
doi = {{10.1084/jem.174.1.297}},
volume = {{174}},
year = {{1991}},
}