Acute respiratory viral infections aggravate arterial endothelial dysfunction in children with type 1 diabetes.
(2004) In Diabetes Care 27(11). p.2733-2735- Abstract
- Despite improvements in therapy for children with type 1 diabetes, the prevalence of cardiovascular morbidity in adulthood due to accelerated atherosclerosis remains significant (1). Similar to other cardiovascular risk factors, the diabetic state facilitates arterial endothelial injury, a primary event in the pathogenesis of atherosclerosis (2). Although several pediatric studies have reported an association of diabetes with arterial endothelial dysfunction (3,4), pathogenic animal studies have suggested that even though this disease predisposes to endothelial dysfunction and atherosclerosis, it might not be sufficient to cause them (5).
Notably, type 1 diabetes increases the propensity for both chronic and acute... (More) - Despite improvements in therapy for children with type 1 diabetes, the prevalence of cardiovascular morbidity in adulthood due to accelerated atherosclerosis remains significant (1). Similar to other cardiovascular risk factors, the diabetic state facilitates arterial endothelial injury, a primary event in the pathogenesis of atherosclerosis (2). Although several pediatric studies have reported an association of diabetes with arterial endothelial dysfunction (3,4), pathogenic animal studies have suggested that even though this disease predisposes to endothelial dysfunction and atherosclerosis, it might not be sufficient to cause them (5).
Notably, type 1 diabetes increases the propensity for both chronic and acute infections in part by weakening the immune mechanisms (6). The risk is particularly increased for respiratory tract infections, but other infections have also been associated with diabetes (7). Furthermore, diabetic patients are at greater risk for infection-related mortality (8), and the excess risk appears to be linked to cardiovascular diseases (9). In the present study, we investigated whether viral respiratory tract infections in children with type 1 diabetes might impose an additional burden on the arterial endothelial function. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/129682
- author
- Aburawi, Elhadi LU ; Liuba, Petru LU ; Pesonen, Erkki LU and Sjöblad, Sture LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes Care
- volume
- 27
- issue
- 11
- pages
- 2733 - 2735
- publisher
- American Diabetes Association
- external identifiers
-
- pmid:15505014
- wos:000224825800027
- scopus:7444272471
- ISSN
- 1935-5548
- DOI
- 10.2337/diacare.27.11.2733
- language
- English
- LU publication?
- yes
- id
- aae5f406-b246-4497-9d76-5e34707f0302 (old id 129682)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15505014&dopt=Abstract
- date added to LUP
- 2016-04-01 16:19:09
- date last changed
- 2022-01-28 18:50:28
@article{aae5f406-b246-4497-9d76-5e34707f0302,
abstract = {{Despite improvements in therapy for children with type 1 diabetes, the prevalence of cardiovascular morbidity in adulthood due to accelerated atherosclerosis remains significant (1). Similar to other cardiovascular risk factors, the diabetic state facilitates arterial endothelial injury, a primary event in the pathogenesis of atherosclerosis (2). Although several pediatric studies have reported an association of diabetes with arterial endothelial dysfunction (3,4), pathogenic animal studies have suggested that even though this disease predisposes to endothelial dysfunction and atherosclerosis, it might not be sufficient to cause them (5).<br/><br>
<br/><br>
Notably, type 1 diabetes increases the propensity for both chronic and acute infections in part by weakening the immune mechanisms (6). The risk is particularly increased for respiratory tract infections, but other infections have also been associated with diabetes (7). Furthermore, diabetic patients are at greater risk for infection-related mortality (8), and the excess risk appears to be linked to cardiovascular diseases (9). In the present study, we investigated whether viral respiratory tract infections in children with type 1 diabetes might impose an additional burden on the arterial endothelial function.}},
author = {{Aburawi, Elhadi and Liuba, Petru and Pesonen, Erkki and Sjöblad, Sture}},
issn = {{1935-5548}},
language = {{eng}},
number = {{11}},
pages = {{2733--2735}},
publisher = {{American Diabetes Association}},
series = {{Diabetes Care}},
title = {{Acute respiratory viral infections aggravate arterial endothelial dysfunction in children with type 1 diabetes.}},
url = {{http://dx.doi.org/10.2337/diacare.27.11.2733}},
doi = {{10.2337/diacare.27.11.2733}},
volume = {{27}},
year = {{2004}},
}