Target position uncertainty during visually guided deep-inspiration breath-hold radiotherapy in locally advanced lung cancer
Scherman Rydhög, Jonas ; Riisgaard de Blanck, Steen ; Josipovic, Mirjana ; Irming Jølck, Rasmus ; Larsen, Klaus Richter ; Clementsen, Paul ; Lars Andersen, Thomas ; Rugaard Poulsen, Per ; Fredberg Persson, Gitte and Munck af Rosenschold, Per LU
(2017)
In Radiotherapy and Oncology
123(1).
p.78-84
- Abstract
Purpose The purpose of this study was to estimate the uncertainty in voluntary deep-inspiration breath-hold (DIBH) radiotherapy for locally advanced non-small cell lung cancer (NSCLC) patients. Methods Perpendicular fluoroscopic movies were acquired in free breathing (FB) and DIBH during a course of visually guided DIBH radiotherapy of nine patients with NSCLC. Patients had liquid markers injected in mediastinal lymph nodes and primary tumours. Excursion, systematic- and random errors, and inter-breath-hold position uncertainty were investigated using an image based tracking algorithm. Results A mean reduction of 2–6 mm in marker excursion in DIBH versus FB was seen in the anterior-posterior (AP), left–right (LR) and cranio-caudal (CC)... (More)
Purpose The purpose of this study was to estimate the uncertainty in voluntary deep-inspiration breath-hold (DIBH) radiotherapy for locally advanced non-small cell lung cancer (NSCLC) patients. Methods Perpendicular fluoroscopic movies were acquired in free breathing (FB) and DIBH during a course of visually guided DIBH radiotherapy of nine patients with NSCLC. Patients had liquid markers injected in mediastinal lymph nodes and primary tumours. Excursion, systematic- and random errors, and inter-breath-hold position uncertainty were investigated using an image based tracking algorithm. Results A mean reduction of 2–6 mm in marker excursion in DIBH versus FB was seen in the anterior-posterior (AP), left–right (LR) and cranio-caudal (CC) directions. Lymph node motion during DIBH originated from cardiac motion. The systematic- (standard deviation (SD) of all the mean marker positions) and random errors (root-mean-square of the intra-BH SD) during DIBH were 0.5 and 0.3 mm (AP), 0.5 and 0.3 mm (LR), 0.8 and 0.4 mm (CC), respectively. The mean inter-breath-hold shifts were −0.3 mm (AP), −0.2 mm (LR), and −0.2 mm (CC). Conclusion Intra- and inter-breath-hold uncertainty of tumours and lymph nodes were small in visually guided breath-hold radiotherapy of NSCLC. Target motion could be substantially reduced, but not eliminated, using visually guided DIBH.
(Less)
- author
- Scherman Rydhög, Jonas
; Riisgaard de Blanck, Steen
; Josipovic, Mirjana
; Irming Jølck, Rasmus
; Larsen, Klaus Richter
; Clementsen, Paul
; Lars Andersen, Thomas
; Rugaard Poulsen, Per
; Fredberg Persson, Gitte
and Munck af Rosenschold, Per
LU
- publishing date
- 2017-04-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Image based tracking, Image-guided radiotherapy, Liquid fiducial marker
- in
- Radiotherapy and Oncology
- volume
- 123
- issue
- 1
- pages
- 7 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:28245908
- scopus:85013767456
- ISSN
- 0167-8140
- DOI
- 10.1016/j.radonc.2017.02.003
- language
- English
- LU publication?
- no
- id
- ab148950-8ba1-4b55-ac73-c54602d5e21f
- date added to LUP
- 2020-07-28 09:00:29
- date last changed
- 2024-04-17 15:03:05
@article{ab148950-8ba1-4b55-ac73-c54602d5e21f,
abstract = {{<p>Purpose The purpose of this study was to estimate the uncertainty in voluntary deep-inspiration breath-hold (DIBH) radiotherapy for locally advanced non-small cell lung cancer (NSCLC) patients. Methods Perpendicular fluoroscopic movies were acquired in free breathing (FB) and DIBH during a course of visually guided DIBH radiotherapy of nine patients with NSCLC. Patients had liquid markers injected in mediastinal lymph nodes and primary tumours. Excursion, systematic- and random errors, and inter-breath-hold position uncertainty were investigated using an image based tracking algorithm. Results A mean reduction of 2–6 mm in marker excursion in DIBH versus FB was seen in the anterior-posterior (AP), left–right (LR) and cranio-caudal (CC) directions. Lymph node motion during DIBH originated from cardiac motion. The systematic- (standard deviation (SD) of all the mean marker positions) and random errors (root-mean-square of the intra-BH SD) during DIBH were 0.5 and 0.3 mm (AP), 0.5 and 0.3 mm (LR), 0.8 and 0.4 mm (CC), respectively. The mean inter-breath-hold shifts were −0.3 mm (AP), −0.2 mm (LR), and −0.2 mm (CC). Conclusion Intra- and inter-breath-hold uncertainty of tumours and lymph nodes were small in visually guided breath-hold radiotherapy of NSCLC. Target motion could be substantially reduced, but not eliminated, using visually guided DIBH.</p>}},
author = {{Scherman Rydhög, Jonas and Riisgaard de Blanck, Steen and Josipovic, Mirjana and Irming Jølck, Rasmus and Larsen, Klaus Richter and Clementsen, Paul and Lars Andersen, Thomas and Rugaard Poulsen, Per and Fredberg Persson, Gitte and Munck af Rosenschold, Per}},
issn = {{0167-8140}},
keywords = {{Image based tracking; Image-guided radiotherapy; Liquid fiducial marker}},
language = {{eng}},
month = {{04}},
number = {{1}},
pages = {{78--84}},
publisher = {{Elsevier}},
series = {{Radiotherapy and Oncology}},
title = {{Target position uncertainty during visually guided deep-inspiration breath-hold radiotherapy in locally advanced lung cancer}},
url = {{http://dx.doi.org/10.1016/j.radonc.2017.02.003}},
doi = {{10.1016/j.radonc.2017.02.003}},
volume = {{123}},
year = {{2017}},
}