Incidence of penile intraepithelial neoplasia and treatment strategies in Sweden 2000–2019
(2022) In BJU International 129(6). p.752-759- Abstract
Objectives: To analyse the incidence, treatment strategies and complications associated with penile intraepithelial neoplasia (PeIN) in Sweden over a period of 20 years. Materials and methods: Data on PeIN from the Swedish National Penile Cancer Register were analysed regarding treatment in relation to age, size of the PeIN lesion, localization of the PeIN lesion and complications using chi-squared tests and logistic regression. The incidence of PeIN was calculated and age-standardized according to the European Standard population. Results: Between 2000 and 2019 a total of 1113 PeIN cases were reported. The age-standardized incidence of PeIN was 1.40 per 100 000 men (95% confidence interval [CI] 1.32–1.49). An increase in incidence over... (More)
Objectives: To analyse the incidence, treatment strategies and complications associated with penile intraepithelial neoplasia (PeIN) in Sweden over a period of 20 years. Materials and methods: Data on PeIN from the Swedish National Penile Cancer Register were analysed regarding treatment in relation to age, size of the PeIN lesion, localization of the PeIN lesion and complications using chi-squared tests and logistic regression. The incidence of PeIN was calculated and age-standardized according to the European Standard population. Results: Between 2000 and 2019 a total of 1113 PeIN cases were reported. The age-standardized incidence of PeIN was 1.40 per 100 000 men (95% confidence interval [CI] 1.32–1.49). An increase in incidence over time was seen, with a standardized incidence rate of 2.37 (95% CI 1.56–3.70) in 2019 compared to the baseline year, 2000. Surgical or topical treatments were given in 75.0% and 14.6% of cases, respectively. The complication rate was higher in laser surgery (12.1%, 7/58) compared to local surgery (4.6%, 16/348; P = 0.03) with an age-adjusted odds ratio (OR) of 2.82 (95% CI 1.10–7.19; P = 0.03). Local surgery was more common than laser surgery in the last 5 years compared to the first 5 years of the study period: OR 5.75 (95% CI 2.94–11.27). Treatments with imiquimod and topical 5-fluorouracil (5-FU) were more common than destructive methods such as photodynamic therapy, cryotherapy, curettage and electrocautery in the last 5 years compared to the first 5 years: OR 9.48 (95% CI 2.29–39.24). Conclusions: A twofold increase in the age-standardized incidence of PeIN was seen in Sweden over 20 years. Complications were three times more common in laser surgery compared to local surgery. Changes in treatment showed an increase of treatment strategies such as local surgery and treatment with imiquimod and topical 5-FU over time.
(Less)
- author
- Kristiansen, Sinja LU ; Torbrand, Christian LU ; Svensson, Åke LU ; Forslund, Ola LU and Bjartling, Carina LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BJU International
- volume
- 129
- issue
- 6
- pages
- 752 - 759
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85123497699
- pmid:35044047
- ISSN
- 1464-4096
- DOI
- 10.1111/bju.15688
- language
- English
- LU publication?
- yes
- id
- ab2cc326-fbfb-4c5d-8de9-3dbcbd5d6508
- date added to LUP
- 2022-04-08 14:47:50
- date last changed
- 2024-06-09 03:02:11
@article{ab2cc326-fbfb-4c5d-8de9-3dbcbd5d6508,
abstract = {{<p>Objectives: To analyse the incidence, treatment strategies and complications associated with penile intraepithelial neoplasia (PeIN) in Sweden over a period of 20 years. Materials and methods: Data on PeIN from the Swedish National Penile Cancer Register were analysed regarding treatment in relation to age, size of the PeIN lesion, localization of the PeIN lesion and complications using chi-squared tests and logistic regression. The incidence of PeIN was calculated and age-standardized according to the European Standard population. Results: Between 2000 and 2019 a total of 1113 PeIN cases were reported. The age-standardized incidence of PeIN was 1.40 per 100 000 men (95% confidence interval [CI] 1.32–1.49). An increase in incidence over time was seen, with a standardized incidence rate of 2.37 (95% CI 1.56–3.70) in 2019 compared to the baseline year, 2000. Surgical or topical treatments were given in 75.0% and 14.6% of cases, respectively. The complication rate was higher in laser surgery (12.1%, 7/58) compared to local surgery (4.6%, 16/348; P = 0.03) with an age-adjusted odds ratio (OR) of 2.82 (95% CI 1.10–7.19; P = 0.03). Local surgery was more common than laser surgery in the last 5 years compared to the first 5 years of the study period: OR 5.75 (95% CI 2.94–11.27). Treatments with imiquimod and topical 5-fluorouracil (5-FU) were more common than destructive methods such as photodynamic therapy, cryotherapy, curettage and electrocautery in the last 5 years compared to the first 5 years: OR 9.48 (95% CI 2.29–39.24). Conclusions: A twofold increase in the age-standardized incidence of PeIN was seen in Sweden over 20 years. Complications were three times more common in laser surgery compared to local surgery. Changes in treatment showed an increase of treatment strategies such as local surgery and treatment with imiquimod and topical 5-FU over time.</p>}},
author = {{Kristiansen, Sinja and Torbrand, Christian and Svensson, Åke and Forslund, Ola and Bjartling, Carina}},
issn = {{1464-4096}},
language = {{eng}},
number = {{6}},
pages = {{752--759}},
publisher = {{Wiley-Blackwell}},
series = {{BJU International}},
title = {{Incidence of penile intraepithelial neoplasia and treatment strategies in Sweden 2000–2019}},
url = {{http://dx.doi.org/10.1111/bju.15688}},
doi = {{10.1111/bju.15688}},
volume = {{129}},
year = {{2022}},
}