Development and postnatal neurogenesis in the retina : a comparison between altricial and precocial bird species
(2021) In Neural Regeneration Research 16(1). p.16-20- Abstract
The visual system is affected by neurodegenerative diseases caused by the degeneration of specific retinal neurons, the leading cause of irreversible blindness in humans. Throughout vertebrate phylogeny, the retina has two kinds of specialized niches of constitutive neurogenesis: the retinal progenitors located in the circumferential marginal zone and Müller glia. The proliferative activity in the retinal progenitors located in the circumferential marginal zone in precocial birds such as the chicken, the commonest bird model used in developmental and regenerative studies, is very low. This region adds only a few retinal cells to the peripheral edge of the retina during several months after hatching, but does not seem to be involved in... (More)
The visual system is affected by neurodegenerative diseases caused by the degeneration of specific retinal neurons, the leading cause of irreversible blindness in humans. Throughout vertebrate phylogeny, the retina has two kinds of specialized niches of constitutive neurogenesis: the retinal progenitors located in the circumferential marginal zone and Müller glia. The proliferative activity in the retinal progenitors located in the circumferential marginal zone in precocial birds such as the chicken, the commonest bird model used in developmental and regenerative studies, is very low. This region adds only a few retinal cells to the peripheral edge of the retina during several months after hatching, but does not seem to be involved in retinal regeneration. Müller cells in the chicken retina are not proliferative under physiological conditions, but after acute damage some of them undergo a reprogramming event, dedifferentiating into retinal stem cells and generating new retinal neurons. Therefore, regenerative response after injury occurs with low efficiency in the precocial avian retina. In contrast, it has recently been shown that neurogenesis is intense in the retina of altricial birds at hatching. In particular, abundant proliferative activity is detected both in the circumferential marginal zone and in the outer half of the inner nuclear layer. Therefore, stem cell niches are very active in the retina of altricial birds. Although more extensive research is needed to assess the potential of proliferating cells in the adult retina of altricial birds, it emerges as an attractive model for studying different aspects of neurogenesis and neural regeneration in vertebrates.
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- author
- Alvarez-Hernan, Guadalupe LU ; de Mera-Rodríguez, José Antonio ; Gañán, Yolanda ; Solana-Fajardo, Jorge ; Martín-Partido, Gervasio ; Rodríguez-León, Joaquín and Francisco-Morcillo, Javier
- publishing date
- 2021-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neural Regeneration Research
- volume
- 16
- issue
- 1
- pages
- 16 - 20
- publisher
- Shenyang Editorial Dept Neural Regeneration Res
- external identifiers
-
- pmid:32788442
- scopus:85091589943
- ISSN
- 1673-5374
- DOI
- 10.4103/1673-5374.286947
- language
- English
- LU publication?
- no
- id
- ab423707-c8ab-4a1d-ad1d-2681f6a7a4fc
- date added to LUP
- 2021-12-15 14:05:29
- date last changed
- 2024-06-17 01:28:46
@article{ab423707-c8ab-4a1d-ad1d-2681f6a7a4fc,
abstract = {{<p>The visual system is affected by neurodegenerative diseases caused by the degeneration of specific retinal neurons, the leading cause of irreversible blindness in humans. Throughout vertebrate phylogeny, the retina has two kinds of specialized niches of constitutive neurogenesis: the retinal progenitors located in the circumferential marginal zone and Müller glia. The proliferative activity in the retinal progenitors located in the circumferential marginal zone in precocial birds such as the chicken, the commonest bird model used in developmental and regenerative studies, is very low. This region adds only a few retinal cells to the peripheral edge of the retina during several months after hatching, but does not seem to be involved in retinal regeneration. Müller cells in the chicken retina are not proliferative under physiological conditions, but after acute damage some of them undergo a reprogramming event, dedifferentiating into retinal stem cells and generating new retinal neurons. Therefore, regenerative response after injury occurs with low efficiency in the precocial avian retina. In contrast, it has recently been shown that neurogenesis is intense in the retina of altricial birds at hatching. In particular, abundant proliferative activity is detected both in the circumferential marginal zone and in the outer half of the inner nuclear layer. Therefore, stem cell niches are very active in the retina of altricial birds. Although more extensive research is needed to assess the potential of proliferating cells in the adult retina of altricial birds, it emerges as an attractive model for studying different aspects of neurogenesis and neural regeneration in vertebrates.</p>}},
author = {{Alvarez-Hernan, Guadalupe and de Mera-Rodríguez, José Antonio and Gañán, Yolanda and Solana-Fajardo, Jorge and Martín-Partido, Gervasio and Rodríguez-León, Joaquín and Francisco-Morcillo, Javier}},
issn = {{1673-5374}},
language = {{eng}},
number = {{1}},
pages = {{16--20}},
publisher = {{Shenyang Editorial Dept Neural Regeneration Res}},
series = {{Neural Regeneration Research}},
title = {{Development and postnatal neurogenesis in the retina : a comparison between altricial and precocial bird species}},
url = {{http://dx.doi.org/10.4103/1673-5374.286947}},
doi = {{10.4103/1673-5374.286947}},
volume = {{16}},
year = {{2021}},
}