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In vivo conversion of dopamine neurons in mouse models of Parkinson's disease - a future approach for regenerative therapy?

Parmar, Malin LU orcid ; Björklund, Anders LU orcid and Björklund, Tomas LU (2021) In Current Opinion in Genetics & Development 70. p.76-82
Abstract

Recent advances in cell reprogramming have made it possible to form new therapeutic cells within the body itself via a process called direct conversion or lineage reprogramming. A series of studies have shown that it is possible to reprogram resident glia into new neurons within the brain parenchyma. These studies opened up for the targeted attempts to achieve functional brain repair using in vivo conversion. Because of the relatively focal degeneration, Parkinson's Disease (PD) is an attractive target for both transplantation-based and in vivo conversion-based reparative approaches. Fetal cell transplants have provided proof-of-concept and stem cell-based therapies for PD are now on the verge of entering clinical trials. In the future,... (More)

Recent advances in cell reprogramming have made it possible to form new therapeutic cells within the body itself via a process called direct conversion or lineage reprogramming. A series of studies have shown that it is possible to reprogram resident glia into new neurons within the brain parenchyma. These studies opened up for the targeted attempts to achieve functional brain repair using in vivo conversion. Because of the relatively focal degeneration, Parkinson's Disease (PD) is an attractive target for both transplantation-based and in vivo conversion-based reparative approaches. Fetal cell transplants have provided proof-of-concept and stem cell-based therapies for PD are now on the verge of entering clinical trials. In the future, in vivo conversion may be an alternative to transplantation-based therapies.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Genetics & Development
volume
70
pages
76 - 82
publisher
Elsevier
external identifiers
  • pmid:34175529
  • scopus:85109407104
ISSN
1879-0380
DOI
10.1016/j.gde.2021.06.002
language
English
LU publication?
yes
id
ab85f2f1-432b-43d3-bedc-03b0b1144e52
date added to LUP
2021-08-03 15:36:00
date last changed
2024-06-15 13:50:22
@article{ab85f2f1-432b-43d3-bedc-03b0b1144e52,
  abstract     = {{<p>Recent advances in cell reprogramming have made it possible to form new therapeutic cells within the body itself via a process called direct conversion or lineage reprogramming. A series of studies have shown that it is possible to reprogram resident glia into new neurons within the brain parenchyma. These studies opened up for the targeted attempts to achieve functional brain repair using in vivo conversion. Because of the relatively focal degeneration, Parkinson's Disease (PD) is an attractive target for both transplantation-based and in vivo conversion-based reparative approaches. Fetal cell transplants have provided proof-of-concept and stem cell-based therapies for PD are now on the verge of entering clinical trials. In the future, in vivo conversion may be an alternative to transplantation-based therapies.</p>}},
  author       = {{Parmar, Malin and Björklund, Anders and Björklund, Tomas}},
  issn         = {{1879-0380}},
  language     = {{eng}},
  month        = {{10}},
  pages        = {{76--82}},
  publisher    = {{Elsevier}},
  series       = {{Current Opinion in Genetics & Development}},
  title        = {{In vivo conversion of dopamine neurons in mouse models of Parkinson's disease - a future approach for regenerative therapy?}},
  url          = {{http://dx.doi.org/10.1016/j.gde.2021.06.002}},
  doi          = {{10.1016/j.gde.2021.06.002}},
  volume       = {{70}},
  year         = {{2021}},
}