Analysis of the IL28RA locus as genetic risk factor for multiple sclerosis
(2012) In Journal of Neuroimmunology 245(1-2). p.98-101- Abstract
Recently, we reported an association between a SNP in IL28RA and MS. Here, we performed a fine-mapping of the IL28RA locus by genotyping 10 haplotype-tagging SNPs in a Basque-Spanish population. In addition, based on shared genetic risk loci between autoimmune diseases, a psoriasis-associated SNP located at this locus, rs4649203, was genotyped in four independent populations, comprising a total of 2582 cases and 2614 controls. We did not find any consistent association between IL28RA and MS in these populations, suggesting that, although it may play a role in other autoimmune diseases, this gene is unlikely of general relevance to MS pathogenesis.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/ab873e93-7249-4e4c-b428-e672f96de95e
- author
- Lopez de Lapuente, A LU ; Alloza, I ; Goertsches, R ; Zettl, U K ; Urcelay, E ; Arroyo, R ; Comabella, M ; Montalban, X ; Antigüedad, A and Vandenbroeck, K
- publishing date
- 2012-04
- type
- Contribution to journal
- publication status
- published
- keywords
- Adult, Case-Control Studies, Cohort Studies, Female, Genetic Loci/genetics, Genetic Predisposition to Disease/epidemiology, Humans, Male, Middle Aged, Multiple Sclerosis/epidemiology, Polymorphism, Genetic/genetics, Receptors, Cytokine/genetics, Risk Factors, Young Adult
- in
- Journal of Neuroimmunology
- volume
- 245
- issue
- 1-2
- pages
- 98 - 101
- publisher
- Elsevier
- external identifiers
-
- scopus:84859641473
- pmid:22386267
- ISSN
- 1872-8421
- DOI
- 10.1016/j.jneuroim.2012.02.005
- language
- English
- LU publication?
- no
- additional info
- Copyright © 2012 Elsevier B.V. All rights reserved.
- id
- ab873e93-7249-4e4c-b428-e672f96de95e
- date added to LUP
- 2021-01-17 18:59:48
- date last changed
- 2024-03-05 21:52:20
@article{ab873e93-7249-4e4c-b428-e672f96de95e, abstract = {{<p>Recently, we reported an association between a SNP in IL28RA and MS. Here, we performed a fine-mapping of the IL28RA locus by genotyping 10 haplotype-tagging SNPs in a Basque-Spanish population. In addition, based on shared genetic risk loci between autoimmune diseases, a psoriasis-associated SNP located at this locus, rs4649203, was genotyped in four independent populations, comprising a total of 2582 cases and 2614 controls. We did not find any consistent association between IL28RA and MS in these populations, suggesting that, although it may play a role in other autoimmune diseases, this gene is unlikely of general relevance to MS pathogenesis.</p>}}, author = {{Lopez de Lapuente, A and Alloza, I and Goertsches, R and Zettl, U K and Urcelay, E and Arroyo, R and Comabella, M and Montalban, X and Antigüedad, A and Vandenbroeck, K}}, issn = {{1872-8421}}, keywords = {{Adult; Case-Control Studies; Cohort Studies; Female; Genetic Loci/genetics; Genetic Predisposition to Disease/epidemiology; Humans; Male; Middle Aged; Multiple Sclerosis/epidemiology; Polymorphism, Genetic/genetics; Receptors, Cytokine/genetics; Risk Factors; Young Adult}}, language = {{eng}}, number = {{1-2}}, pages = {{98--101}}, publisher = {{Elsevier}}, series = {{Journal of Neuroimmunology}}, title = {{Analysis of the IL28RA locus as genetic risk factor for multiple sclerosis}}, url = {{http://dx.doi.org/10.1016/j.jneuroim.2012.02.005}}, doi = {{10.1016/j.jneuroim.2012.02.005}}, volume = {{245}}, year = {{2012}}, }