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Analysis of the IL28RA locus as genetic risk factor for multiple sclerosis

Lopez de Lapuente, A LU ; Alloza, I ; Goertsches, R ; Zettl, U K ; Urcelay, E ; Arroyo, R ; Comabella, M ; Montalban, X ; Antigüedad, A and Vandenbroeck, K (2012) In Journal of Neuroimmunology 245(1-2). p.98-101
Abstract

Recently, we reported an association between a SNP in IL28RA and MS. Here, we performed a fine-mapping of the IL28RA locus by genotyping 10 haplotype-tagging SNPs in a Basque-Spanish population. In addition, based on shared genetic risk loci between autoimmune diseases, a psoriasis-associated SNP located at this locus, rs4649203, was genotyped in four independent populations, comprising a total of 2582 cases and 2614 controls. We did not find any consistent association between IL28RA and MS in these populations, suggesting that, although it may play a role in other autoimmune diseases, this gene is unlikely of general relevance to MS pathogenesis.

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author
; ; ; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Adult, Case-Control Studies, Cohort Studies, Female, Genetic Loci/genetics, Genetic Predisposition to Disease/epidemiology, Humans, Male, Middle Aged, Multiple Sclerosis/epidemiology, Polymorphism, Genetic/genetics, Receptors, Cytokine/genetics, Risk Factors, Young Adult
in
Journal of Neuroimmunology
volume
245
issue
1-2
pages
98 - 101
publisher
Elsevier
external identifiers
  • pmid:22386267
  • scopus:84859641473
ISSN
1872-8421
DOI
10.1016/j.jneuroim.2012.02.005
language
English
LU publication?
no
additional info
Copyright © 2012 Elsevier B.V. All rights reserved.
id
ab873e93-7249-4e4c-b428-e672f96de95e
date added to LUP
2021-01-17 18:59:48
date last changed
2024-03-05 21:52:20
@article{ab873e93-7249-4e4c-b428-e672f96de95e,
  abstract     = {{<p>Recently, we reported an association between a SNP in IL28RA and MS. Here, we performed a fine-mapping of the IL28RA locus by genotyping 10 haplotype-tagging SNPs in a Basque-Spanish population. In addition, based on shared genetic risk loci between autoimmune diseases, a psoriasis-associated SNP located at this locus, rs4649203, was genotyped in four independent populations, comprising a total of 2582 cases and 2614 controls. We did not find any consistent association between IL28RA and MS in these populations, suggesting that, although it may play a role in other autoimmune diseases, this gene is unlikely of general relevance to MS pathogenesis.</p>}},
  author       = {{Lopez de Lapuente, A and Alloza, I and Goertsches, R and Zettl, U K and Urcelay, E and Arroyo, R and Comabella, M and Montalban, X and Antigüedad, A and Vandenbroeck, K}},
  issn         = {{1872-8421}},
  keywords     = {{Adult; Case-Control Studies; Cohort Studies; Female; Genetic Loci/genetics; Genetic Predisposition to Disease/epidemiology; Humans; Male; Middle Aged; Multiple Sclerosis/epidemiology; Polymorphism, Genetic/genetics; Receptors, Cytokine/genetics; Risk Factors; Young Adult}},
  language     = {{eng}},
  number       = {{1-2}},
  pages        = {{98--101}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Neuroimmunology}},
  title        = {{Analysis of the IL28RA locus as genetic risk factor for multiple sclerosis}},
  url          = {{http://dx.doi.org/10.1016/j.jneuroim.2012.02.005}},
  doi          = {{10.1016/j.jneuroim.2012.02.005}},
  volume       = {{245}},
  year         = {{2012}},
}