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Exposure of men and lactating women to environmental phenols, phthalates, and DINCH

Runkel, Agneta A. LU orcid ; Mazej, Darja ; Snoj Tratnik, Janja ; Tkalec, Žiga ; Kosjek, Tina and Horvat, Milena (2022) In Chemosphere 286. p.1-13
Abstract

Phthalates and 1,2-Cyclohexane dicarboxylic acid diisononyl ester (DINCH), bisphenols (BPs), parabens (PBs), and triclosan (TCS) are high-production-volume chemicals of pseudo-persistence that are concerning for the environment and human health. This study aims to assess the exposure to 10 phthalates, DINCH, and environmental phenols (3 BPs, 7 PBs, and TCS) of Slovenian men (n = 548) and lactating primiparous women (n = 536). We observed urinary concentrations comparable to studies from other countries and significant differences among the sub-populations. In our study, men had significantly higher levels of phthalates, DINCH, and BPs, whereas the concentrations of PBs in urine were significantly higher in women. The most significant... (More)

Phthalates and 1,2-Cyclohexane dicarboxylic acid diisononyl ester (DINCH), bisphenols (BPs), parabens (PBs), and triclosan (TCS) are high-production-volume chemicals of pseudo-persistence that are concerning for the environment and human health. This study aims to assess the exposure to 10 phthalates, DINCH, and environmental phenols (3 BPs, 7 PBs, and TCS) of Slovenian men (n = 548) and lactating primiparous women (n = 536). We observed urinary concentrations comparable to studies from other countries and significant differences among the sub-populations. In our study, men had significantly higher levels of phthalates, DINCH, and BPs, whereas the concentrations of PBs in urine were significantly higher in women. The most significant determinant of exposure was the area of residence and the year of sampling (2008–2014) that mirrors trends in the market. Participants from urban or industrialized sampling locations had higher levels of almost all monitored analytes compared to rural locations. In an attempt to assess the risk of the population, hazard quotient (HQ) values were calculated for individual compounds and the chemical mixture. Individual analytes do not seem to pose a risk to the studied population at current exposure levels, whereas the HQ value of the chemical mixture is near the threshold of 1 which would indicate a higher risk. We conclude that greater emphasis on the risk resulting from cumulative exposure to chemical mixtures and additional studies are needed to estimate the exposure of susceptible populations, such as children.

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author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
DINCH, Endocrine disrupting chemicals, Human biomonitoring, Phenols, Phthalates, Risk assessment
in
Chemosphere
volume
286
article number
131858
pages
1 - 13
publisher
Elsevier
external identifiers
  • scopus:85112268675
  • pmid:34399256
ISSN
0045-6535
DOI
10.1016/j.chemosphere.2021.131858
language
English
LU publication?
no
additional info
Publisher Copyright: © 2021 The Authors
id
abca07be-4b79-423c-97fe-d8b577fe0e56
date added to LUP
2025-02-18 17:25:47
date last changed
2025-07-09 05:19:47
@article{abca07be-4b79-423c-97fe-d8b577fe0e56,
  abstract     = {{<p>Phthalates and 1,2-Cyclohexane dicarboxylic acid diisononyl ester (DINCH), bisphenols (BPs), parabens (PBs), and triclosan (TCS) are high-production-volume chemicals of pseudo-persistence that are concerning for the environment and human health. This study aims to assess the exposure to 10 phthalates, DINCH, and environmental phenols (3 BPs, 7 PBs, and TCS) of Slovenian men (n = 548) and lactating primiparous women (n = 536). We observed urinary concentrations comparable to studies from other countries and significant differences among the sub-populations. In our study, men had significantly higher levels of phthalates, DINCH, and BPs, whereas the concentrations of PBs in urine were significantly higher in women. The most significant determinant of exposure was the area of residence and the year of sampling (2008–2014) that mirrors trends in the market. Participants from urban or industrialized sampling locations had higher levels of almost all monitored analytes compared to rural locations. In an attempt to assess the risk of the population, hazard quotient (HQ) values were calculated for individual compounds and the chemical mixture. Individual analytes do not seem to pose a risk to the studied population at current exposure levels, whereas the HQ value of the chemical mixture is near the threshold of 1 which would indicate a higher risk. We conclude that greater emphasis on the risk resulting from cumulative exposure to chemical mixtures and additional studies are needed to estimate the exposure of susceptible populations, such as children.</p>}},
  author       = {{Runkel, Agneta A. and Mazej, Darja and Snoj Tratnik, Janja and Tkalec, Žiga and Kosjek, Tina and Horvat, Milena}},
  issn         = {{0045-6535}},
  keywords     = {{DINCH; Endocrine disrupting chemicals; Human biomonitoring; Phenols; Phthalates; Risk assessment}},
  language     = {{eng}},
  pages        = {{1--13}},
  publisher    = {{Elsevier}},
  series       = {{Chemosphere}},
  title        = {{Exposure of men and lactating women to environmental phenols, phthalates, and DINCH}},
  url          = {{http://dx.doi.org/10.1016/j.chemosphere.2021.131858}},
  doi          = {{10.1016/j.chemosphere.2021.131858}},
  volume       = {{286}},
  year         = {{2022}},
}