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Allogeneic hematopoietic stem cell transplant with reduced-intensity conditioning for chronic lymphocytic leukemia in Sweden: does donor T-cell engraftment 3 months after transplant predict survival?

Machaczka, Maciej ; Johansson, Jan-Erik ; Remberger, Mats ; Hallbook, Helene ; Malm, Claes ; Lazarevic, Vladimir LU ; Wahlin, Anders ; Omar, Hamdy ; Juliusson, Gunnar LU and Kimby, Eva , et al. (2012) In Leukemia & Lymphoma 53(9). p.1699-1705
Abstract
Thirty-eight adult patients with chronic lymphocytic leukemia (CLL) underwent reduced-intensity conditioning (RIC) allogeneic stem cell transplant (allo-SCT) in Sweden between 1999 and 2007. The cumulative incidences of acute graft-versus-host disease (GVHD) grades II-IV and chronic GVHD were 29% and 47%, respectively. Rates of non-relapse mortality, progression-free survival (PFS) and overall survival (OS) were 18%, 47% and 74% at 1 year, and 21%, 25% and 45% at 5 years, respectively. T-cell chimerism after transplant was measured in 31 out of 34 patients (91%) surviving beyond day + 100. Seventeen patients achieved > 90% donor T-cell engraftment at 3 months after allo-SCT and, compared with the 12 patients with <= 90% donor T-cell... (More)
Thirty-eight adult patients with chronic lymphocytic leukemia (CLL) underwent reduced-intensity conditioning (RIC) allogeneic stem cell transplant (allo-SCT) in Sweden between 1999 and 2007. The cumulative incidences of acute graft-versus-host disease (GVHD) grades II-IV and chronic GVHD were 29% and 47%, respectively. Rates of non-relapse mortality, progression-free survival (PFS) and overall survival (OS) were 18%, 47% and 74% at 1 year, and 21%, 25% and 45% at 5 years, respectively. T-cell chimerism after transplant was measured in 31 out of 34 patients (91%) surviving beyond day + 100. Seventeen patients achieved > 90% donor T-cell engraftment at 3 months after allo-SCT and, compared with the 12 patients with <= 90% donor T-cell engraftment, they showed favorable PFS at 1 year (82% vs. 33%, p = 0.002) and better long-term PFS and OS (p = 0.002 and 0.046, respectively). Donor T-cell engraftment of > 90% at 3 months after RIC allo-SCT for CLL seems to predict favorable short-term and long-term outcome. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Allogeneic stem cell transplant, chronic lymphocytic leukemia, T-cell, donor engraftment
in
Leukemia & Lymphoma
volume
53
issue
9
pages
1699 - 1705
publisher
Taylor & Francis
external identifiers
  • wos:000307301500012
  • scopus:84864996370
  • pmid:22335529
ISSN
1042-8194
DOI
10.3109/10428194.2012.666661
language
English
LU publication?
yes
id
abcb9dd8-0e09-4089-b0f7-e7fdf9cd4a9a (old id 3147742)
date added to LUP
2016-04-01 13:01:57
date last changed
2022-01-27 08:57:05
@article{abcb9dd8-0e09-4089-b0f7-e7fdf9cd4a9a,
  abstract     = {{Thirty-eight adult patients with chronic lymphocytic leukemia (CLL) underwent reduced-intensity conditioning (RIC) allogeneic stem cell transplant (allo-SCT) in Sweden between 1999 and 2007. The cumulative incidences of acute graft-versus-host disease (GVHD) grades II-IV and chronic GVHD were 29% and 47%, respectively. Rates of non-relapse mortality, progression-free survival (PFS) and overall survival (OS) were 18%, 47% and 74% at 1 year, and 21%, 25% and 45% at 5 years, respectively. T-cell chimerism after transplant was measured in 31 out of 34 patients (91%) surviving beyond day + 100. Seventeen patients achieved &gt; 90% donor T-cell engraftment at 3 months after allo-SCT and, compared with the 12 patients with &lt;= 90% donor T-cell engraftment, they showed favorable PFS at 1 year (82% vs. 33%, p = 0.002) and better long-term PFS and OS (p = 0.002 and 0.046, respectively). Donor T-cell engraftment of &gt; 90% at 3 months after RIC allo-SCT for CLL seems to predict favorable short-term and long-term outcome.}},
  author       = {{Machaczka, Maciej and Johansson, Jan-Erik and Remberger, Mats and Hallbook, Helene and Malm, Claes and Lazarevic, Vladimir and Wahlin, Anders and Omar, Hamdy and Juliusson, Gunnar and Kimby, Eva and Hagglund, Hans}},
  issn         = {{1042-8194}},
  keywords     = {{Allogeneic stem cell transplant; chronic lymphocytic leukemia; T-cell; donor engraftment}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{1699--1705}},
  publisher    = {{Taylor & Francis}},
  series       = {{Leukemia & Lymphoma}},
  title        = {{Allogeneic hematopoietic stem cell transplant with reduced-intensity conditioning for chronic lymphocytic leukemia in Sweden: does donor T-cell engraftment 3 months after transplant predict survival?}},
  url          = {{http://dx.doi.org/10.3109/10428194.2012.666661}},
  doi          = {{10.3109/10428194.2012.666661}},
  volume       = {{53}},
  year         = {{2012}},
}