Emerging role of SOX11 in mantle cell lymphoma
Kuci, Venera LU ; Nordström, Lena LU ; Jerkeman, Mats LU and Ek, Sara LU
(2015)
In Blood and Lymphatic Cancer: Targets and Therapy
5.
p.35-41
- Abstract
- During recent years the neural transcription factor SOX11 has been established as an important biomarker for mantle cell lymphoma. SOX11 is both a diagnostic and prognostic antigen, and may potentially be used for treatment selection for younger patients, in relation to protocols including high dose chemotherapy. The molecular pathways involved are still not fully elucidated and, as SOX11 can interact with several co-transcription factors, functional assays need to be carefully designed to pinpoint SOX11-specific function in a defined cellular context. Furthermore, as SOX11 belongs to a large family of homologous proteins, analysis of SOX11 has been limited by the availability of specific antibodies for detection and pull-down. In this... (More)
- During recent years the neural transcription factor SOX11 has been established as an important biomarker for mantle cell lymphoma. SOX11 is both a diagnostic and prognostic antigen, and may potentially be used for treatment selection for younger patients, in relation to protocols including high dose chemotherapy. The molecular pathways involved are still not fully elucidated and, as SOX11 can interact with several co-transcription factors, functional assays need to be carefully designed to pinpoint SOX11-specific function in a defined cellular context. Furthermore, as SOX11 belongs to a large family of homologous proteins, analysis of SOX11 has been limited by the availability of specific antibodies for detection and pull-down. In this review, we discuss the emerging role of SOX11 in mantle cell lymphoma and discuss the potential impact in relation to tumorigenesis, diagnostics, prognostics, and therapy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8560072
- author
- Kuci, Venera
LU
; Nordström, Lena
LU
; Jerkeman, Mats
LU
and Ek, Sara
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- SOX11, mantle cell lymphoma, diagnostic
- in
- Blood and Lymphatic Cancer: Targets and Therapy
- volume
- 5
- pages
- 35 - 41
- publisher
- Dove Medical Press Ltd.
- external identifiers
-
- wos:000366112100002
- ISSN
- 1179-9889
- DOI
- 10.2147/BLCTT.S60447
- language
- English
- LU publication?
- yes
- id
- abcebe2a-7a29-4587-8964-d7be407ae3d4 (old id 8560072)
- date added to LUP
- 2016-04-01 13:11:22
- date last changed
- 2018-11-21 20:13:13
@article{abcebe2a-7a29-4587-8964-d7be407ae3d4,
abstract = {{During recent years the neural transcription factor SOX11 has been established as an important biomarker for mantle cell lymphoma. SOX11 is both a diagnostic and prognostic antigen, and may potentially be used for treatment selection for younger patients, in relation to protocols including high dose chemotherapy. The molecular pathways involved are still not fully elucidated and, as SOX11 can interact with several co-transcription factors, functional assays need to be carefully designed to pinpoint SOX11-specific function in a defined cellular context. Furthermore, as SOX11 belongs to a large family of homologous proteins, analysis of SOX11 has been limited by the availability of specific antibodies for detection and pull-down. In this review, we discuss the emerging role of SOX11 in mantle cell lymphoma and discuss the potential impact in relation to tumorigenesis, diagnostics, prognostics, and therapy.}},
author = {{Kuci, Venera and Nordström, Lena and Jerkeman, Mats and Ek, Sara}},
issn = {{1179-9889}},
keywords = {{SOX11; mantle cell lymphoma; diagnostic}},
language = {{eng}},
pages = {{35--41}},
publisher = {{Dove Medical Press Ltd.}},
series = {{Blood and Lymphatic Cancer: Targets and Therapy}},
title = {{Emerging role of SOX11 in mantle cell lymphoma}},
url = {{http://dx.doi.org/10.2147/BLCTT.S60447}},
doi = {{10.2147/BLCTT.S60447}},
volume = {{5}},
year = {{2015}},
}