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Inverse association between serum albumin and depressive symptoms among drug-free individuals with a recent suicide attempt

Ambrus, Livia LU and Westling, Sofie LU (2019) In Nordic Journal of Psychiatry 73(4-5). p.229-232
Abstract

BACKGROUND AND AIM: Albumin is a protein with multifaceted functions in the human body. According to many studies, lower serum albumin may be associated with depression in various groups of psychiatric and non-psychiatric patients, as well as with attempted suicide. As more severe depressive symptoms have been identified as a reliable risk factor for suicide in patients with high suicide risk, it would be of interest to study whether, the inverse association between depressive symptoms and albumin may exist among patients with attempted suicide. Therefore, the aim of the study was to investigate the possible association between albumin and depressive symptoms among individuals who recently attempted suicide.

METHODS: One-hundred... (More)

BACKGROUND AND AIM: Albumin is a protein with multifaceted functions in the human body. According to many studies, lower serum albumin may be associated with depression in various groups of psychiatric and non-psychiatric patients, as well as with attempted suicide. As more severe depressive symptoms have been identified as a reliable risk factor for suicide in patients with high suicide risk, it would be of interest to study whether, the inverse association between depressive symptoms and albumin may exist among patients with attempted suicide. Therefore, the aim of the study was to investigate the possible association between albumin and depressive symptoms among individuals who recently attempted suicide.

METHODS: One-hundred twenty-seven individuals with a recent suicide attempt were involved in the study between 1987 and 2001. Albumin was analyzed in serum. Patients were evaluated with the Comprehensive Psychopathological Rating Scale (CPRS) from which the Montgomery-Åsberg Depression Rating Scale (MADRS) and the item assessing Apparent sadness were derived.

RESULTS: Only among patients aged ≥45, serum albumin levels were significantly and negatively correlated with total scores of MADRS and the item Apparent sadness (all p values <.00625).

CONCLUSIONS: Our findings indicate an inverse association between serum albumin and the severity of depressive symptoms in individuals who attempted suicide, older than 45 years.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nordic Journal of Psychiatry
volume
73
issue
4-5
pages
229 - 232
publisher
Informa Healthcare
external identifiers
  • scopus:85065533912
ISSN
1502-4725
DOI
10.1080/08039488.2019.1610056
language
English
LU publication?
yes
id
abd91191-3706-4d5f-928e-310b98570dff
date added to LUP
2019-05-21 16:46:45
date last changed
2019-06-27 14:31:27
@article{abd91191-3706-4d5f-928e-310b98570dff,
  abstract     = {<p>BACKGROUND AND AIM: Albumin is a protein with multifaceted functions in the human body. According to many studies, lower serum albumin may be associated with depression in various groups of psychiatric and non-psychiatric patients, as well as with attempted suicide. As more severe depressive symptoms have been identified as a reliable risk factor for suicide in patients with high suicide risk, it would be of interest to study whether, the inverse association between depressive symptoms and albumin may exist among patients with attempted suicide. Therefore, the aim of the study was to investigate the possible association between albumin and depressive symptoms among individuals who recently attempted suicide.</p><p>METHODS: One-hundred twenty-seven individuals with a recent suicide attempt were involved in the study between 1987 and 2001. Albumin was analyzed in serum. Patients were evaluated with the Comprehensive Psychopathological Rating Scale (CPRS) from which the Montgomery-Åsberg Depression Rating Scale (MADRS) and the item assessing Apparent sadness were derived.</p><p>RESULTS: Only among patients aged ≥45, serum albumin levels were significantly and negatively correlated with total scores of MADRS and the item Apparent sadness (all p values &lt;.00625).</p><p>CONCLUSIONS: Our findings indicate an inverse association between serum albumin and the severity of depressive symptoms in individuals who attempted suicide, older than 45 years.</p>},
  author       = {Ambrus, Livia and Westling, Sofie},
  issn         = {1502-4725},
  language     = {eng},
  month        = {05},
  number       = {4-5},
  pages        = {229--232},
  publisher    = {Informa Healthcare},
  series       = {Nordic Journal of Psychiatry},
  title        = {Inverse association between serum albumin and depressive symptoms among drug-free individuals with a recent suicide attempt},
  url          = {http://dx.doi.org/10.1080/08039488.2019.1610056},
  volume       = {73},
  year         = {2019},
}