Genetic diversity in hepatitis C virus in Egypt and possible association with hepatocellular carcinoma
(2007) In Journal of General Virology 88(5). p.1526-1531- Abstract
- Egypt has one of the world's highest prevalences of hepatitis C virus (HCV) infection, with a majority of genotype 4 infections. To explore the genetic diversity of HCV in Egypt, sera from 131 Egyptians [56 from community studies, 37 chronic hepatitis patients, 28 hepatocellular carcinoma (HCC) patients and 10 patients with non-Hodgkin's lymphoma] were genotyped by restriction fragment-length polymorphism and phylogenetic analyses of sequences from the mid-core and non-structural 5B regions. The different genotyping methods showed good agreement. The majority of the viruses (83 of 131; 63 %) were of subtype 4a, but five other subtypes within genotype 4 were also observed, as well as three genotype 1b, five genotype 1g and one genotype 3a... (More)
- Egypt has one of the world's highest prevalences of hepatitis C virus (HCV) infection, with a majority of genotype 4 infections. To explore the genetic diversity of HCV in Egypt, sera from 131 Egyptians [56 from community studies, 37 chronic hepatitis patients, 28 hepatocellular carcinoma (HCC) patients and 10 patients with non-Hodgkin's lymphoma] were genotyped by restriction fragment-length polymorphism and phylogenetic analyses of sequences from the mid-core and non-structural 5B regions. The different genotyping methods showed good agreement. The majority of the viruses (83 of 131; 63 %) were of subtype 4a, but five other subtypes within genotype 4 were also observed, as well as three genotype 1b, five genotype 1g and one genotype 3a samples. Interestingly, subtype 4o, which was easily identifiable in all three genomic regions, 3 showed an association with HCC (P=0.017), which merits further investigation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/659421
- author
- Abdel-Hamid, Mohamed ; El-Daly, Mai ; Molnegren, Vilma ; El-Kafrawy, Sherif ; Abdel-Latif, Sohair ; Esmat, Gamal ; Strickland, G. Thomas ; Loffredo, Christopher ; Albert, Jan and Widell, Anders LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of General Virology
- volume
- 88
- issue
- 5
- pages
- 1526 - 1531
- publisher
- Microbiology Society
- external identifiers
-
- wos:000246532300017
- scopus:34248220080
- ISSN
- 1465-2099
- DOI
- 10.1099/vir.0.82626-0
- language
- English
- LU publication?
- yes
- id
- abe57d10-29e8-4a03-9f11-d0de0c62b087 (old id 659421)
- date added to LUP
- 2016-04-01 16:40:12
- date last changed
- 2022-04-07 17:49:41
@article{abe57d10-29e8-4a03-9f11-d0de0c62b087, abstract = {{Egypt has one of the world's highest prevalences of hepatitis C virus (HCV) infection, with a majority of genotype 4 infections. To explore the genetic diversity of HCV in Egypt, sera from 131 Egyptians [56 from community studies, 37 chronic hepatitis patients, 28 hepatocellular carcinoma (HCC) patients and 10 patients with non-Hodgkin's lymphoma] were genotyped by restriction fragment-length polymorphism and phylogenetic analyses of sequences from the mid-core and non-structural 5B regions. The different genotyping methods showed good agreement. The majority of the viruses (83 of 131; 63 %) were of subtype 4a, but five other subtypes within genotype 4 were also observed, as well as three genotype 1b, five genotype 1g and one genotype 3a samples. Interestingly, subtype 4o, which was easily identifiable in all three genomic regions, 3 showed an association with HCC (P=0.017), which merits further investigation.}}, author = {{Abdel-Hamid, Mohamed and El-Daly, Mai and Molnegren, Vilma and El-Kafrawy, Sherif and Abdel-Latif, Sohair and Esmat, Gamal and Strickland, G. Thomas and Loffredo, Christopher and Albert, Jan and Widell, Anders}}, issn = {{1465-2099}}, language = {{eng}}, number = {{5}}, pages = {{1526--1531}}, publisher = {{Microbiology Society}}, series = {{Journal of General Virology}}, title = {{Genetic diversity in hepatitis C virus in Egypt and possible association with hepatocellular carcinoma}}, url = {{http://dx.doi.org/10.1099/vir.0.82626-0}}, doi = {{10.1099/vir.0.82626-0}}, volume = {{88}}, year = {{2007}}, }