Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Impact of head rotation on the individualized common carotid flow and carotid bifurcation hemodynamics

Aristokleous, Nicolas LU orcid ; Seimenis, Ioannis ; Georgiou, Georgios C ; Papaharilaou, Yannis ; Brott, Brigitta C ; Nicolaides, Andrew and Anayiotos, Andreas S (2014) In IEEE Journal of Biomedical and Health Informatics 18(3). p.9-783
Abstract

This paper aims at evaluating the changes that head rotation poses on morphological and flow characteristics of the carotid bifurcation (CB) and on the distribution of parameters that are regarded as important in atherosclerosis development, such as relative particle residence time (RRT), normalized oscillatory shear index (nOSI), and helicity (HL). Using a subject-specific approach, six healthy volunteers were MR-scanned in two head postures: supine neutral and prone with rightward head rotation. Cross-sectional flow velocity distribution was obtained using phase-contrast MRI at the common carotid artery (CCA). Our results indicate that peak systolic flow rate is reduced at the prone position in most cases for both CCAs. Morphological... (More)

This paper aims at evaluating the changes that head rotation poses on morphological and flow characteristics of the carotid bifurcation (CB) and on the distribution of parameters that are regarded as important in atherosclerosis development, such as relative particle residence time (RRT), normalized oscillatory shear index (nOSI), and helicity (HL). Using a subject-specific approach, six healthy volunteers were MR-scanned in two head postures: supine neutral and prone with rightward head rotation. Cross-sectional flow velocity distribution was obtained using phase-contrast MRI at the common carotid artery (CCA). Our results indicate that peak systolic flow rate is reduced at the prone position in most cases for both CCAs. Morphological MR images are used to segment and construct the CB models. Numerical simulations are performed and areas exposed to high helicity or unfavorable hemodynamics are calculated. Head rotation affects the instantaneous spatial extent of high helicity regions. Posture-related observed differences in the distribution of nOSI and RRT suggest that inlet flow waveform tends to moderate geometry-induced changes in the qualitative and quantitative distribution of atherosclerosis-susceptible wall regions. Overall, presented results indicate that an individualized approach is required to fully assess the postural role in atherosclerosis development and in complications arising in stenotic and stented vessels.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Atherosclerosis, Carotid Artery Diseases, Carotid Artery, Common/anatomy & histology, Computer Simulation, Hemodynamics/physiology, Humans, Imaging, Three-Dimensional/methods, Magnetic Resonance Imaging, Male, Models, Cardiovascular, Posture/physiology, Young Adult
in
IEEE Journal of Biomedical and Health Informatics
volume
18
issue
3
pages
7 pages
publisher
IEEE - Institute of Electrical and Electronics Engineers Inc.
external identifiers
  • pmid:24808222
  • scopus:84900550958
ISSN
2168-2194
DOI
10.1109/JBHI.2014.2305575
language
English
LU publication?
no
id
ac10fc50-e1c4-4748-92d9-746ac7cdee29
date added to LUP
2019-05-14 09:36:30
date last changed
2024-01-01 04:16:04
@article{ac10fc50-e1c4-4748-92d9-746ac7cdee29,
  abstract     = {{<p>This paper aims at evaluating the changes that head rotation poses on morphological and flow characteristics of the carotid bifurcation (CB) and on the distribution of parameters that are regarded as important in atherosclerosis development, such as relative particle residence time (RRT), normalized oscillatory shear index (nOSI), and helicity (HL). Using a subject-specific approach, six healthy volunteers were MR-scanned in two head postures: supine neutral and prone with rightward head rotation. Cross-sectional flow velocity distribution was obtained using phase-contrast MRI at the common carotid artery (CCA). Our results indicate that peak systolic flow rate is reduced at the prone position in most cases for both CCAs. Morphological MR images are used to segment and construct the CB models. Numerical simulations are performed and areas exposed to high helicity or unfavorable hemodynamics are calculated. Head rotation affects the instantaneous spatial extent of high helicity regions. Posture-related observed differences in the distribution of nOSI and RRT suggest that inlet flow waveform tends to moderate geometry-induced changes in the qualitative and quantitative distribution of atherosclerosis-susceptible wall regions. Overall, presented results indicate that an individualized approach is required to fully assess the postural role in atherosclerosis development and in complications arising in stenotic and stented vessels. </p>}},
  author       = {{Aristokleous, Nicolas and Seimenis, Ioannis and Georgiou, Georgios C and Papaharilaou, Yannis and Brott, Brigitta C and Nicolaides, Andrew and Anayiotos, Andreas S}},
  issn         = {{2168-2194}},
  keywords     = {{Adult; Atherosclerosis; Carotid Artery Diseases; Carotid Artery, Common/anatomy & histology; Computer Simulation; Hemodynamics/physiology; Humans; Imaging, Three-Dimensional/methods; Magnetic Resonance Imaging; Male; Models, Cardiovascular; Posture/physiology; Young Adult}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{9--783}},
  publisher    = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}},
  series       = {{IEEE Journal of Biomedical and Health Informatics}},
  title        = {{Impact of head rotation on the individualized common carotid flow and carotid bifurcation hemodynamics}},
  url          = {{http://dx.doi.org/10.1109/JBHI.2014.2305575}},
  doi          = {{10.1109/JBHI.2014.2305575}},
  volume       = {{18}},
  year         = {{2014}},
}