Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Renal impairment after hip or knee arthroplasty. Urinary excretion of protein markers studied in 59 patients

Nergelius, Görel LU ; Vinge, Ellen LU ; Grubb, Anders LU orcid and Lidgren, Lars LU (1997) In Acta Orthopaedica Scandinavica 68(1). p.34-40
Abstract

We studied renal function during and after surgery in 38 patients undergoing total hip replacement (THR) and 21 patients undergoing total knee replacement (TKR). Serum creatinine and renal excretion of albumin, IgG, protein HC and creatinine were recorded preoperatively and on days 1, 2, 4, and 8, THR patients were randomized to treatment with (n 17) or without (n 21) prophylactic isoxazolyl penicillins, which all TKR patients had. In all 3 groups, the primary concentration of proteins increased postoperatively with a peak in the glomerular markers (albumin, IgG) on days 1 and 2, and in the tubular marker (protein HC) on days 2 and 4. There were no statistically significant differences between the groups. On day 8, all urinary protein... (More)

We studied renal function during and after surgery in 38 patients undergoing total hip replacement (THR) and 21 patients undergoing total knee replacement (TKR). Serum creatinine and renal excretion of albumin, IgG, protein HC and creatinine were recorded preoperatively and on days 1, 2, 4, and 8, THR patients were randomized to treatment with (n 17) or without (n 21) prophylactic isoxazolyl penicillins, which all TKR patients had. In all 3 groups, the primary concentration of proteins increased postoperatively with a peak in the glomerular markers (albumin, IgG) on days 1 and 2, and in the tubular marker (protein HC) on days 2 and 4. There were no statistically significant differences between the groups. On day 8, all urinary protein concentrations had essentially returned to their preoperative levels. Serum creatinine decreased by 10% in THR patients on day 1 and then returned to baseline levels, but there was a gradual increase up to 13% in TKR patients.

(Less)
Please use this url to cite or link to this publication:
author
; ; and
publishing date
type
Contribution to journal
publication status
published
in
Acta Orthopaedica Scandinavica
volume
68
issue
1
pages
34 - 40
publisher
Taylor & Francis
external identifiers
  • pmid:9057565
  • scopus:0031045792
ISSN
0001-6470
DOI
10.3109/17453679709003972
language
English
LU publication?
no
additional info
Funding Information: This study was supported by grants from the Swedish Medical Research Council (MFR 09509). the Faculty of Medicine, University of Lund and the Malmohus County Council. We thank the staff at the Departments of Orthopedics and Anesthesia and Intensive Care for help throughout the study.
id
ac2b4f30-6758-4a8a-bcf4-2981e5a4923a
date added to LUP
2021-10-29 10:27:14
date last changed
2024-01-12 02:54:29
@article{ac2b4f30-6758-4a8a-bcf4-2981e5a4923a,
  abstract     = {{<p>We studied renal function during and after surgery in 38 patients undergoing total hip replacement (THR) and 21 patients undergoing total knee replacement (TKR). Serum creatinine and renal excretion of albumin, IgG, protein HC and creatinine were recorded preoperatively and on days 1, 2, 4, and 8, THR patients were randomized to treatment with (n 17) or without (n 21) prophylactic isoxazolyl penicillins, which all TKR patients had. In all 3 groups, the primary concentration of proteins increased postoperatively with a peak in the glomerular markers (albumin, IgG) on days 1 and 2, and in the tubular marker (protein HC) on days 2 and 4. There were no statistically significant differences between the groups. On day 8, all urinary protein concentrations had essentially returned to their preoperative levels. Serum creatinine decreased by 10% in THR patients on day 1 and then returned to baseline levels, but there was a gradual increase up to 13% in TKR patients.</p>}},
  author       = {{Nergelius, Görel and Vinge, Ellen and Grubb, Anders and Lidgren, Lars}},
  issn         = {{0001-6470}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{34--40}},
  publisher    = {{Taylor & Francis}},
  series       = {{Acta Orthopaedica Scandinavica}},
  title        = {{Renal impairment after hip or knee arthroplasty. Urinary excretion of protein markers studied in 59 patients}},
  url          = {{http://dx.doi.org/10.3109/17453679709003972}},
  doi          = {{10.3109/17453679709003972}},
  volume       = {{68}},
  year         = {{1997}},
}