Prevalence of zinc transporter 8 antibodies in gestational diabetes mellitus.
Dereke, Jonatan LU
; Nilsson, C
; Landin-Olsson, Mona
LU
and Hillman, Magnus
LU
(2012)
In Diabetic Medicine: A journal of the British Diabetic Association
- Abstract
- Aims:
Gestational diabetes mellitus affects approximately 7% of all pregnant women. Some of these women develop autoantibodies that are generally characteristic of Type 1 diabetes. Autoantibodies targeting glutamic acid decarboxylase and tyrosine phosphatase-like protein are the most frequently reported. A recently identified autoantigen in Type 1 diabetes is zinc transporter 8. Some reports suggest that the frequency of zinc transporter 8 antibodies is as high as glutamic acid decarboxylase antibodies in Type 1 diabetes and thus a good diagnostic marker for autoimmune diabetes. There are currently no reports of zinc transporter 8 antibodies in gestational diabetes. The aim of this pilot study was to investigate the frequency of... (More) - Aims:
Gestational diabetes mellitus affects approximately 7% of all pregnant women. Some of these women develop autoantibodies that are generally characteristic of Type 1 diabetes. Autoantibodies targeting glutamic acid decarboxylase and tyrosine phosphatase-like protein are the most frequently reported. A recently identified autoantigen in Type 1 diabetes is zinc transporter 8. Some reports suggest that the frequency of zinc transporter 8 antibodies is as high as glutamic acid decarboxylase antibodies in Type 1 diabetes and thus a good diagnostic marker for autoimmune diabetes. There are currently no reports of zinc transporter 8 antibodies in gestational diabetes. The aim of this pilot study was to investigate the frequency of zinc transporter 8 antibodies in patients at clinical onset of gestational diabetes mellitus.
Methods:
Subjects included in this pilot study were all diagnosed with gestational diabetes at Skåne University Hospital, Lund, Sweden, 2009-2010 (n = 193). Sera samples were analysed for antibodies using a commercial enzyme-linked immunosorbent assay according to the manufacturers' instructions.
Results:
We found that 19/193 patients with gestational diabetes, diagnosed in 2009-2010, were positive for at least one autoantibody. Glutamic acid decarboxylase was the most common single autoantibody (52.6%; 10/19), followed by zinc transporter 8 (21.1%; 4/19) and tyrosine phosphatase-like protein (15.8%; 3/19). Combinations of two or more antibodies were rare (10.5%; 2/19).
Conclusions:
In this study, we found that zinc transporter 8 added 2.1% (4/193) of autoantibody positivity in women with gestational diabetes who were negative for glutamic acid decarboxylase and tyrosine phosphatase-like protein antibodies. Glutamic acid decarboxylase was still the most prevalent autoantibody in gestational diabetes, but, as zinc transporter 8 was present even in the absence of glutamic acid decarboxylase, this autoantibody could be an important independent marker of autoimmunity in gestational diabetes. © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3047163
- author
- Dereke, Jonatan
LU
; Nilsson, C
; Landin-Olsson, Mona
LU
and Hillman, Magnus
LU
- organization
- publishing date
- 2012-08-24
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetic Medicine: A journal of the British Diabetic Association
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000311054600002
- pmid:22924602
- scopus:84869106655
- pmid:22924602
- ISSN
- 1464-5491
- DOI
- 10.1111/j.1464-5491.2012.03766.x
- language
- English
- LU publication?
- yes
- id
- ac68ebb2-dccc-4d78-8bbb-821e5471a32b (old id 3047163)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22924602?dopt=Abstract
- date added to LUP
- 2016-04-04 09:13:20
- date last changed
- 2024-01-12 10:36:39
@article{ac68ebb2-dccc-4d78-8bbb-821e5471a32b,
abstract = {{Aims: <br/><br>
Gestational diabetes mellitus affects approximately 7% of all pregnant women. Some of these women develop autoantibodies that are generally characteristic of Type 1 diabetes. Autoantibodies targeting glutamic acid decarboxylase and tyrosine phosphatase-like protein are the most frequently reported. A recently identified autoantigen in Type 1 diabetes is zinc transporter 8. Some reports suggest that the frequency of zinc transporter 8 antibodies is as high as glutamic acid decarboxylase antibodies in Type 1 diabetes and thus a good diagnostic marker for autoimmune diabetes. There are currently no reports of zinc transporter 8 antibodies in gestational diabetes. The aim of this pilot study was to investigate the frequency of zinc transporter 8 antibodies in patients at clinical onset of gestational diabetes mellitus. <br/><br>
<br/><br>
Methods: <br/><br>
Subjects included in this pilot study were all diagnosed with gestational diabetes at Skåne University Hospital, Lund, Sweden, 2009-2010 (n = 193). Sera samples were analysed for antibodies using a commercial enzyme-linked immunosorbent assay according to the manufacturers' instructions. <br/><br>
<br/><br>
Results: <br/><br>
We found that 19/193 patients with gestational diabetes, diagnosed in 2009-2010, were positive for at least one autoantibody. Glutamic acid decarboxylase was the most common single autoantibody (52.6%; 10/19), followed by zinc transporter 8 (21.1%; 4/19) and tyrosine phosphatase-like protein (15.8%; 3/19). Combinations of two or more antibodies were rare (10.5%; 2/19). <br/><br>
<br/><br>
Conclusions:<br/><br>
In this study, we found that zinc transporter 8 added 2.1% (4/193) of autoantibody positivity in women with gestational diabetes who were negative for glutamic acid decarboxylase and tyrosine phosphatase-like protein antibodies. Glutamic acid decarboxylase was still the most prevalent autoantibody in gestational diabetes, but, as zinc transporter 8 was present even in the absence of glutamic acid decarboxylase, this autoantibody could be an important independent marker of autoimmunity in gestational diabetes. © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK.}},
author = {{Dereke, Jonatan and Nilsson, C and Landin-Olsson, Mona and Hillman, Magnus}},
issn = {{1464-5491}},
language = {{eng}},
month = {{08}},
publisher = {{Wiley-Blackwell}},
series = {{Diabetic Medicine: A journal of the British Diabetic Association}},
title = {{Prevalence of zinc transporter 8 antibodies in gestational diabetes mellitus.}},
url = {{http://dx.doi.org/10.1111/j.1464-5491.2012.03766.x}},
doi = {{10.1111/j.1464-5491.2012.03766.x}},
year = {{2012}},
}