The Role of Nitric Oxide Synthase in Post-Operative Hyperglycaemia
(2008) In Libyan Journal of Medicine 3(3). p.144-147- Abstract
- Post-operative hyperglycaemia is important with regard to outcomes of surgical operations. It affects postoperative morbidity, length of hospital stay, and mortality. Poor peri-operative blood glucose control leads to a higher risk of post-operative complication. Insulin resistance as a cause of post-operative hyperglycaemia has been blamed for some time. Nitric Oxide (NO) is produced by nitric oxide synthase (NOS) isoenzymes. Inducible nitric oxide synthase (iNOS) is not a normal cellular constitute. It is expressed by cytokines and non-cytokines e. g. fasting, trauma, intravenous glucose, and lipid infusion, which are encountered in surgical operations. Review of current published data on postoperative hyperglycaemia was completed. Our... (More)
- Post-operative hyperglycaemia is important with regard to outcomes of surgical operations. It affects postoperative morbidity, length of hospital stay, and mortality. Poor peri-operative blood glucose control leads to a higher risk of post-operative complication. Insulin resistance as a cause of post-operative hyperglycaemia has been blamed for some time. Nitric Oxide (NO) is produced by nitric oxide synthase (NOS) isoenzymes. Inducible nitric oxide synthase (iNOS) is not a normal cellular constitute. It is expressed by cytokines and non-cytokines e. g. fasting, trauma, intravenous glucose, and lipid infusion, which are encountered in surgical operations. Review of current published data on postoperative hyperglycaemia was completed. Our studies and others were explored for the possible role of NO in this scenario. Induction and expression of iNOS enzyme in pancreatic islet cells is included in the chaotic postoperative blood glucose control. The high concentrations of iNOS derived NO are toxic to pancreatic beta-cells and may inhibit insulin secretion postoperatively. Hence, current peri-operative management is questionable regarding post-operative hyperglycaemia and necessitates development of a new strategy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4442989
- author
- Qader, Saleem LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- NO, glucotoxicity, lipotoxicity, post-operative hyperglycaemia, pancreatic islets
- in
- Libyan Journal of Medicine
- volume
- 3
- issue
- 3
- pages
- 144 - 147
- publisher
- Univ Alfateh, Fac Med
- external identifiers
-
- wos:000207456200009
- ISSN
- 1993-2820
- language
- English
- LU publication?
- yes
- id
- ac7cb0d2-e0e1-4079-a7e0-2ed9b747cc9c (old id 4442989)
- date added to LUP
- 2016-04-01 11:57:46
- date last changed
- 2018-11-21 20:02:14
@article{ac7cb0d2-e0e1-4079-a7e0-2ed9b747cc9c,
abstract = {{Post-operative hyperglycaemia is important with regard to outcomes of surgical operations. It affects postoperative morbidity, length of hospital stay, and mortality. Poor peri-operative blood glucose control leads to a higher risk of post-operative complication. Insulin resistance as a cause of post-operative hyperglycaemia has been blamed for some time. Nitric Oxide (NO) is produced by nitric oxide synthase (NOS) isoenzymes. Inducible nitric oxide synthase (iNOS) is not a normal cellular constitute. It is expressed by cytokines and non-cytokines e. g. fasting, trauma, intravenous glucose, and lipid infusion, which are encountered in surgical operations. Review of current published data on postoperative hyperglycaemia was completed. Our studies and others were explored for the possible role of NO in this scenario. Induction and expression of iNOS enzyme in pancreatic islet cells is included in the chaotic postoperative blood glucose control. The high concentrations of iNOS derived NO are toxic to pancreatic beta-cells and may inhibit insulin secretion postoperatively. Hence, current peri-operative management is questionable regarding post-operative hyperglycaemia and necessitates development of a new strategy.}},
author = {{Qader, Saleem}},
issn = {{1993-2820}},
keywords = {{NO; glucotoxicity; lipotoxicity; post-operative hyperglycaemia; pancreatic islets}},
language = {{eng}},
number = {{3}},
pages = {{144--147}},
publisher = {{Univ Alfateh, Fac Med}},
series = {{Libyan Journal of Medicine}},
title = {{The Role of Nitric Oxide Synthase in Post-Operative Hyperglycaemia}},
volume = {{3}},
year = {{2008}},
}