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Road-traffic noise exposure and coronary atherosclerosis in the Swedish CArdioPulmonary bioImage Study (SCAPIS)

Murzabekov, Marat ; Persson, Åsa ; Asker, Christian ; Kilbo Edlund, Karl ; Eriksson, Charlotta ; Jernberg, Tomas ; Molnar, Peter ; Oudin, Anna LU orcid ; Pyko, Andrei and Lindvall, Jenny , et al. (2024) In Environmental Epidemiology 8(5). p.344-344
Abstract

Background: Road-traffic noise may influence the development of cardiovascular events such as stroke and myocardial infarction, but etiological mechanisms remain unclear. This study aimed to assess the relationship between long-term road-traffic noise exposure and coronary atherosclerosis in Sweden. Methods: In the Swedish CArdioPulmonary bioImage Study (SCAPIS) cohort, including 30,154 subjects aged 50-65 years, recruited between 2013 and 2018, coronary atherosclerosis was measured based on computer tomography (CT) scans as coronary artery calcium score, segment involvement score (SIS), and non-calcified plaques (NCP) at enrollment. Based on modified Nordic model, road-traffic noise exposure was modeled for 2000, 2013, and 2018 with... (More)

Background: Road-traffic noise may influence the development of cardiovascular events such as stroke and myocardial infarction, but etiological mechanisms remain unclear. This study aimed to assess the relationship between long-term road-traffic noise exposure and coronary atherosclerosis in Sweden. Methods: In the Swedish CArdioPulmonary bioImage Study (SCAPIS) cohort, including 30,154 subjects aged 50-65 years, recruited between 2013 and 2018, coronary atherosclerosis was measured based on computer tomography (CT) scans as coronary artery calcium score, segment involvement score (SIS), and non-calcified plaques (NCP) at enrollment. Based on modified Nordic model, road-traffic noise exposure was modeled for 2000, 2013, and 2018 with interpolation for intermediate years. We investigated the association between time-weighted long-term exposure to road-traffic noise (Lden) and the prevalence of atherosclerosis using ordinal logistic regression models adjusting for potential socioeconomic, behavioral, and environmental confounders, including air pollution. Results: No clear associations were found between road-traffic noise and coronary atherosclerosis. The odds ratio for coronary artery calcium score was 1.00 (95% confidence interval [CI] = 0.96, 1.04), SIS 0.99 (0.96, 1.03), and NCP 0.98 (0.90, 1.03) per interquartile range (9.4 dB Lden) for road-traffic noise exposure during 10 years before enrollment. No consistent associations were observed in site-specific analyses or using shorter exposure periods. Furthermore, exposure-response analyses revealed no clear trends, and there were no strong interactions between road-traffic noise and cardiovascular risk factors in relation to the atherosclerosis markers. Conclusions: Long-term exposure to road-traffic noise was not linked to coronary atherosclerosis or calcification in relatively healthy, middle-aged populations in Sweden.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
atherosclerosis, cardiovascular disease, noise, road traffic noise
in
Environmental Epidemiology
volume
8
issue
5
pages
344 - 344
publisher
Wolters Kluwer
external identifiers
  • scopus:85206671625
  • pmid:39371586
ISSN
2474-7882
DOI
10.1097/EE9.0000000000000344
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2024 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved.
id
ac922b02-0278-42dd-abff-536ea44cc607
date added to LUP
2024-12-18 09:45:51
date last changed
2025-07-17 02:40:12
@article{ac922b02-0278-42dd-abff-536ea44cc607,
  abstract     = {{<p>Background: Road-traffic noise may influence the development of cardiovascular events such as stroke and myocardial infarction, but etiological mechanisms remain unclear. This study aimed to assess the relationship between long-term road-traffic noise exposure and coronary atherosclerosis in Sweden. Methods: In the Swedish CArdioPulmonary bioImage Study (SCAPIS) cohort, including 30,154 subjects aged 50-65 years, recruited between 2013 and 2018, coronary atherosclerosis was measured based on computer tomography (CT) scans as coronary artery calcium score, segment involvement score (SIS), and non-calcified plaques (NCP) at enrollment. Based on modified Nordic model, road-traffic noise exposure was modeled for 2000, 2013, and 2018 with interpolation for intermediate years. We investigated the association between time-weighted long-term exposure to road-traffic noise (Lden) and the prevalence of atherosclerosis using ordinal logistic regression models adjusting for potential socioeconomic, behavioral, and environmental confounders, including air pollution. Results: No clear associations were found between road-traffic noise and coronary atherosclerosis. The odds ratio for coronary artery calcium score was 1.00 (95% confidence interval [CI] = 0.96, 1.04), SIS 0.99 (0.96, 1.03), and NCP 0.98 (0.90, 1.03) per interquartile range (9.4 dB Lden) for road-traffic noise exposure during 10 years before enrollment. No consistent associations were observed in site-specific analyses or using shorter exposure periods. Furthermore, exposure-response analyses revealed no clear trends, and there were no strong interactions between road-traffic noise and cardiovascular risk factors in relation to the atherosclerosis markers. Conclusions: Long-term exposure to road-traffic noise was not linked to coronary atherosclerosis or calcification in relatively healthy, middle-aged populations in Sweden.</p>}},
  author       = {{Murzabekov, Marat and Persson, Åsa and Asker, Christian and Kilbo Edlund, Karl and Eriksson, Charlotta and Jernberg, Tomas and Molnar, Peter and Oudin, Anna and Pyko, Andrei and Lindvall, Jenny and Lõhmus, Mare and Persson Waye, Kerstin and Nilsson Sommar, Johan and Stockfelt, Leo and Spanne, Mårten and Svartengren, Magnus and Ögren, Mikael and Pershagen, Göran and Ljungman, Petter}},
  issn         = {{2474-7882}},
  keywords     = {{atherosclerosis; cardiovascular disease; noise; road traffic noise}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{5}},
  pages        = {{344--344}},
  publisher    = {{Wolters Kluwer}},
  series       = {{Environmental Epidemiology}},
  title        = {{Road-traffic noise exposure and coronary atherosclerosis in the Swedish CArdioPulmonary bioImage Study (SCAPIS)}},
  url          = {{http://dx.doi.org/10.1097/EE9.0000000000000344}},
  doi          = {{10.1097/EE9.0000000000000344}},
  volume       = {{8}},
  year         = {{2024}},
}