Thermoresponsive properties of sugar sensitive copolymer of N-isopropylacrylamide and 3-(acrylamido)phenylboronic acid
(2004) In Macromolecular Chemistry and Physics 205(1). p.27-34- Abstract
- The copolymer of N-isopropylacrylamide and 3-(acrylamido)phenylboronic acid (82:18, (M) over bar (n)=47000 g. mol(-1)) was prepared by free radical polymerization. The copolymer showed typical thermal precipitation behavior in aqueous solutions, its precipitation temperature (T-P) being increased from 23 to 32degreesC by increasing the pH from 6.5 to 9.7, because of ionization of the phenylboronate units. The pK(a) was evaluated as 8.9+/-0.1 from the effect of pH on T-P. At pH>9, i.e., in the anionic form of the copolymer, T-P was affected by a very low concentration of glucose (5.6 muM, DeltaT(P)=1-1.5degreesC), because of complex formation with a high binding constant. At a higher concentration of polyols (560 muM, pH>8) the... (More)
- The copolymer of N-isopropylacrylamide and 3-(acrylamido)phenylboronic acid (82:18, (M) over bar (n)=47000 g. mol(-1)) was prepared by free radical polymerization. The copolymer showed typical thermal precipitation behavior in aqueous solutions, its precipitation temperature (T-P) being increased from 23 to 32degreesC by increasing the pH from 6.5 to 9.7, because of ionization of the phenylboronate units. The pK(a) was evaluated as 8.9+/-0.1 from the effect of pH on T-P. At pH>9, i.e., in the anionic form of the copolymer, T-P was affected by a very low concentration of glucose (5.6 muM, DeltaT(P)=1-1.5degreesC), because of complex formation with a high binding constant. At a higher concentration of polyols (560 muM, pH>8) the increase of T-P was maximal for the copolymer complexes with fructose (7-10degreesC) and decreased in the order: fructose>glucoseapproximate tomannitol>pentaerythritol>galactose>Tris>glycerol. Di- and oligosaccharides (lactose, sucrose, and dextran) caused a slight increase of T-P at pH 7.5-8.7 while no effect was observed at pH>9. Isothermal dissolution of the copolymer suspension in water (27degreesC, pH 8.5) was possible in the. presence of fructose or mannitol but required higher concentrations (1.4-3.6 x 10(3) muM) as compared to those which enabled the shift of T-P in the soluble copolymer. The dissolution rate increased with fructose concentrations. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/140743
- author
- Shiomori, Koichiro LU ; Ivanov, Alexander LU ; Galaev, Igor LU ; Kawano, Y and Mattiasson, Bo LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Macromolecular Chemistry and Physics
- volume
- 205
- issue
- 1
- pages
- 27 - 34
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000188800100003
- scopus:1142298877
- ISSN
- 1521-3935
- DOI
- 10.1002/macp.200300019
- language
- English
- LU publication?
- yes
- id
- acb2296a-d181-48c3-a520-7160713eb583 (old id 140743)
- date added to LUP
- 2016-04-01 12:16:08
- date last changed
- 2022-04-05 20:06:05
@article{acb2296a-d181-48c3-a520-7160713eb583,
abstract = {{The copolymer of N-isopropylacrylamide and 3-(acrylamido)phenylboronic acid (82:18, (M) over bar (n)=47000 g. mol(-1)) was prepared by free radical polymerization. The copolymer showed typical thermal precipitation behavior in aqueous solutions, its precipitation temperature (T-P) being increased from 23 to 32degreesC by increasing the pH from 6.5 to 9.7, because of ionization of the phenylboronate units. The pK(a) was evaluated as 8.9+/-0.1 from the effect of pH on T-P. At pH>9, i.e., in the anionic form of the copolymer, T-P was affected by a very low concentration of glucose (5.6 muM, DeltaT(P)=1-1.5degreesC), because of complex formation with a high binding constant. At a higher concentration of polyols (560 muM, pH>8) the increase of T-P was maximal for the copolymer complexes with fructose (7-10degreesC) and decreased in the order: fructose>glucoseapproximate tomannitol>pentaerythritol>galactose>Tris>glycerol. Di- and oligosaccharides (lactose, sucrose, and dextran) caused a slight increase of T-P at pH 7.5-8.7 while no effect was observed at pH>9. Isothermal dissolution of the copolymer suspension in water (27degreesC, pH 8.5) was possible in the. presence of fructose or mannitol but required higher concentrations (1.4-3.6 x 10(3) muM) as compared to those which enabled the shift of T-P in the soluble copolymer. The dissolution rate increased with fructose concentrations.}},
author = {{Shiomori, Koichiro and Ivanov, Alexander and Galaev, Igor and Kawano, Y and Mattiasson, Bo}},
issn = {{1521-3935}},
language = {{eng}},
number = {{1}},
pages = {{27--34}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Macromolecular Chemistry and Physics}},
title = {{Thermoresponsive properties of sugar sensitive copolymer of N-isopropylacrylamide and 3-(acrylamido)phenylboronic acid}},
url = {{http://dx.doi.org/10.1002/macp.200300019}},
doi = {{10.1002/macp.200300019}},
volume = {{205}},
year = {{2004}},
}