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Association between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals : A Longitudinal Descriptive Cohort Study

Reijs, Babette L.R.; Vos, Stephanie J.B.; Soininen, Hilkka; Lötjonen, Jyrki; Koikkalainen, Juha; Pikkarainen, Maria; Hall, Anette; Vanninen, Ritva; Liu, Yawu and Herukka, Sanna Kaisa, et al. (2017) In Journal of Alzheimer's Disease 60(4). p.1387-1395
Abstract

Background: Lifestyle factors have been associated with the risk of dementia, but the association with Alzheimer's disease (AD) remains unclear. Objective: To examine the association between later life lifestyle factors and AD biomarkers (i.e., amyloid-β 1-42 (Aβ 42) and tau in cerebrospinal fluid (CSF), and hippocampal volume) in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). In addition, to examine the effect of later life lifestyle factors on developing AD-type dementia in individuals with MCI. Methods: We selected individuals with SCD (n = 111) and MCI (n = 353) from the DESCRIPA and Kuopio Longitudinal MCI studies. CSF Aβ 42 and tau concentrations were assessed with ELISA assay and... (More)

Background: Lifestyle factors have been associated with the risk of dementia, but the association with Alzheimer's disease (AD) remains unclear. Objective: To examine the association between later life lifestyle factors and AD biomarkers (i.e., amyloid-β 1-42 (Aβ 42) and tau in cerebrospinal fluid (CSF), and hippocampal volume) in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). In addition, to examine the effect of later life lifestyle factors on developing AD-type dementia in individuals with MCI. Methods: We selected individuals with SCD (n = 111) and MCI (n = 353) from the DESCRIPA and Kuopio Longitudinal MCI studies. CSF Aβ 42 and tau concentrations were assessed with ELISA assay and hippocampal volume with multi-atlas segmentation. Lifestyle was assessed by clinical interview at baseline for: social activity, physical activity, cognitive activity, smoking, alcohol consumption, and sleep. We performed logistic and Cox regression analyses adjusted for study site, age, gender, education, and diagnosis. Prediction for AD-type dementia was performed in individuals with MCI only. Results: Later life lifestyle factors were not associated with AD biomarkers or with conversion to AD-type dementia. AD biomarkers were strongly associated with conversion to AD-type dementia, but these relations were not modulated by lifestyle factors. Apolipoprotein E (APOE) genotype did not influence the results. Conclusions: Later life lifestyle factors had no impact on key AD biomarkers in individuals with SCD and MCI or on conversion to AD-type dementia in MCI.

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keywords
Alcohol consumption, Alzheimer's disease, amyloid-β (1-42), cerebrospinal fluid, cognitive reserve, exercise, hippocampus, lifestyle, mild cognitive impairment
in
Journal of Alzheimer's Disease
volume
60
issue
4
pages
9 pages
publisher
IOS Press
external identifiers
  • scopus:85033561388
  • wos:000414612200017
ISSN
1387-2877
DOI
10.3233/JAD-170039
language
English
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yes
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ad3a5460-d73f-4c6c-ab2a-793ed4243abc
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2017-12-01 12:57:06
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2018-03-03 03:00:08
@article{ad3a5460-d73f-4c6c-ab2a-793ed4243abc,
  abstract     = {<p>Background: Lifestyle factors have been associated with the risk of dementia, but the association with Alzheimer's disease (AD) remains unclear. Objective: To examine the association between later life lifestyle factors and AD biomarkers (i.e., amyloid-β 1-42 (Aβ 42) and tau in cerebrospinal fluid (CSF), and hippocampal volume) in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). In addition, to examine the effect of later life lifestyle factors on developing AD-type dementia in individuals with MCI. Methods: We selected individuals with SCD (n = 111) and MCI (n = 353) from the DESCRIPA and Kuopio Longitudinal MCI studies. CSF Aβ 42 and tau concentrations were assessed with ELISA assay and hippocampal volume with multi-atlas segmentation. Lifestyle was assessed by clinical interview at baseline for: social activity, physical activity, cognitive activity, smoking, alcohol consumption, and sleep. We performed logistic and Cox regression analyses adjusted for study site, age, gender, education, and diagnosis. Prediction for AD-type dementia was performed in individuals with MCI only. Results: Later life lifestyle factors were not associated with AD biomarkers or with conversion to AD-type dementia. AD biomarkers were strongly associated with conversion to AD-type dementia, but these relations were not modulated by lifestyle factors. Apolipoprotein E (APOE) genotype did not influence the results. Conclusions: Later life lifestyle factors had no impact on key AD biomarkers in individuals with SCD and MCI or on conversion to AD-type dementia in MCI.</p>},
  author       = {Reijs, Babette L.R. and Vos, Stephanie J.B. and Soininen, Hilkka and Lötjonen, Jyrki and Koikkalainen, Juha and Pikkarainen, Maria and Hall, Anette and Vanninen, Ritva and Liu, Yawu and Herukka, Sanna Kaisa and Freund-Levi, Yvonne and Frisoni, Giovanni B. and Frölich, Lutz and Nobili, Flavio and Rikkert, Marcel Olde and Spiru, Luiza and Tsolaki, Magda and Wallin, Åsa K. and Scheltens, Philip and Verhey, Frans and Visser, Pieter Jelle},
  issn         = {1387-2877},
  keyword      = {Alcohol consumption,Alzheimer's disease,amyloid-β (1-42),cerebrospinal fluid,cognitive reserve,exercise,hippocampus,lifestyle,mild cognitive impairment},
  language     = {eng},
  number       = {4},
  pages        = {1387--1395},
  publisher    = {IOS Press},
  series       = {Journal of Alzheimer's Disease},
  title        = {Association between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals : A Longitudinal Descriptive Cohort Study},
  url          = {http://dx.doi.org/10.3233/JAD-170039},
  volume       = {60},
  year         = {2017},
}