Understanding cellular growth strategies via optimal control
Mononen, Tommi ; Kuosmanen, Teemu ; Cairns, Johannes LU
and Mustonen, Ville
(2023)
In Journal of the Royal Society, Interface
20(198).
p.1-10
- Abstract
Evolutionary prediction and control are increasingly interesting research topics that are expanding to new areas of application. Unravelling and anticipating successful adaptations to different selection pressures becomes crucial when steering rapidly evolving cancer or microbial populations towards a chosen target. Here we introduce and apply a rich theoretical framework of optimal control to understand adaptive use of traits, which in turn allows eco-evolutionarily informed population control. Using adaptive metabolism and microbial experimental evolution as a case study, we show how demographic stochasticity alone can lead to lag time evolution, which appears as an emergent property in our model. We further show that the cycle length... (More)
Evolutionary prediction and control are increasingly interesting research topics that are expanding to new areas of application. Unravelling and anticipating successful adaptations to different selection pressures becomes crucial when steering rapidly evolving cancer or microbial populations towards a chosen target. Here we introduce and apply a rich theoretical framework of optimal control to understand adaptive use of traits, which in turn allows eco-evolutionarily informed population control. Using adaptive metabolism and microbial experimental evolution as a case study, we show how demographic stochasticity alone can lead to lag time evolution, which appears as an emergent property in our model. We further show that the cycle length used in serial transfer experiments has practical importance as it may cause unintentional selection for specific growth strategies and lag times. Finally, we show how frequency-dependent selection can be incorporated to the state-dependent optimal control framework allowing the modelling of complex eco-evolutionary dynamics. Our study demonstrates the utility of optimal control theory in elucidating organismal adaptations and the intrinsic decision making of cellular communities with high adaptive potential.
(Less)
- author
- Mononen, Tommi
; Kuosmanen, Teemu
; Cairns, Johannes
LU
and Mustonen, Ville
- publishing date
- 2023-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Biological Evolution, Adaptation, Physiological, Phenotype, Cell Cycle, Acclimatization
- in
- Journal of the Royal Society, Interface
- volume
- 20
- issue
- 198
- article number
- 20220744
- pages
- 1 - 10
- publisher
- The Royal Society of Canada
- external identifiers
-
- pmid:36596459
- scopus:85145429399
- ISSN
- 1742-5662
- DOI
- 10.1098/rsif.2022.0744
- language
- English
- LU publication?
- no
- id
- ad8d27e5-1df8-45a4-b23f-f0a78e11052c
- date added to LUP
- 2026-03-05 09:24:25
- date last changed
- 2026-10-04 22:03:00
@article{ad8d27e5-1df8-45a4-b23f-f0a78e11052c,
abstract = {{<p>Evolutionary prediction and control are increasingly interesting research topics that are expanding to new areas of application. Unravelling and anticipating successful adaptations to different selection pressures becomes crucial when steering rapidly evolving cancer or microbial populations towards a chosen target. Here we introduce and apply a rich theoretical framework of optimal control to understand adaptive use of traits, which in turn allows eco-evolutionarily informed population control. Using adaptive metabolism and microbial experimental evolution as a case study, we show how demographic stochasticity alone can lead to lag time evolution, which appears as an emergent property in our model. We further show that the cycle length used in serial transfer experiments has practical importance as it may cause unintentional selection for specific growth strategies and lag times. Finally, we show how frequency-dependent selection can be incorporated to the state-dependent optimal control framework allowing the modelling of complex eco-evolutionary dynamics. Our study demonstrates the utility of optimal control theory in elucidating organismal adaptations and the intrinsic decision making of cellular communities with high adaptive potential.</p>}},
author = {{Mononen, Tommi and Kuosmanen, Teemu and Cairns, Johannes and Mustonen, Ville}},
issn = {{1742-5662}},
keywords = {{Biological Evolution; Adaptation, Physiological; Phenotype; Cell Cycle; Acclimatization}},
language = {{eng}},
number = {{198}},
pages = {{1--10}},
publisher = {{The Royal Society of Canada}},
series = {{Journal of the Royal Society, Interface}},
title = {{Understanding cellular growth strategies via optimal control}},
url = {{http://dx.doi.org/10.1098/rsif.2022.0744}},
doi = {{10.1098/rsif.2022.0744}},
volume = {{20}},
year = {{2023}},
}