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Increased perfusion in dynamic gadolinium-enhanced MRI correlates with areas of bone repair and of bone necrosis in patients with Kienböck's disease

Müller, Gunilla LU ; Månsson, Sven LU ; Müller, Markus F. LU ; Johansson, Martin LU and Björkman, Anders LU (2018) In Journal of Magnetic Resonance Imaging
Abstract

Background: Osteonecrosis of the lunate, Kienböck's disease, can lead to fragmentation of the lunate, carpal collapse, and severe osteoarthritis. Since the etiology of Kienböck's disease is impaired circulation, a diagnostic method capable of assessing perfusion would be valuable. Recent studies have suggested that dynamic contrast-enhanced (DCE) MR examinations at 3 T can assess perfusion in healthy carpal bones. Purpose: To evaluate the use of DCE-MR for assessing perfusion in the lunate bone in patients with Kienböck's disease. Furthermore, to compare perfusion with histopathology with a focus on bone viability. Study Type: Prospective case–control study. Population: Fourteen patients with Kienböck's disease and a control group of 19... (More)

Background: Osteonecrosis of the lunate, Kienböck's disease, can lead to fragmentation of the lunate, carpal collapse, and severe osteoarthritis. Since the etiology of Kienböck's disease is impaired circulation, a diagnostic method capable of assessing perfusion would be valuable. Recent studies have suggested that dynamic contrast-enhanced (DCE) MR examinations at 3 T can assess perfusion in healthy carpal bones. Purpose: To evaluate the use of DCE-MR for assessing perfusion in the lunate bone in patients with Kienböck's disease. Furthermore, to compare perfusion with histopathology with a focus on bone viability. Study Type: Prospective case–control study. Population: Fourteen patients with Kienböck's disease and a control group of 19 healthy subjects. Field Strength: 3 T with T1-weighted fat-saturated contrast-enhanced gradient echo series. Assessment: Features of the enhancement curves from the DCE-MR examinations, time to peak (TTP), maximum slope (MS), and maximum enhancement (ME) assessed by a radiologist. Six of 14 patients were surgerized with lunate excision, allowing comparison between features of the enhancement curves and histopathology. Statistical Tests: Mann–Whitney U-test. P < 0.05 was considered a statistically significant difference. Results: Patients with Kienböck's disease showed significantly higher and faster perfusion parameters compared with the control group, the mean value of the TTP in patients was 126.73 sec, in controls 189.79 sec (P = 0.024), ME in patients 173.55 AU, in controls 28.46 AU (P < 0.001), and MS in patients 5.04 AU, in controls 1.06 AU (P < 0.001). When compared with histopathology, increased perfusion was seen in areas of bone formation but also in necrosis. Areas of normal bone showed low perfusion. Data Conclusion: DCE-MRI at 3 T can diagnose altered perfusion in patients with Kienböck's disease. Increased perfusion cannot definitely be used as a marker of bone viability. Level of Evidence: 1. Technical Efficacy: Stage 3. J. Magn. Reson. Imaging 2018.

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author
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type
Contribution to journal
publication status
epub
subject
keywords
dynamic MRI, histology, Kienböck's disease, lunate, viability
in
Journal of Magnetic Resonance Imaging
publisher
John Wiley & Sons
external identifiers
  • scopus:85058685672
ISSN
1053-1807
DOI
10.1002/jmri.26573
language
English
LU publication?
yes
id
ad96358c-329e-4f80-82fa-d39efe894997
date added to LUP
2019-01-07 12:36:38
date last changed
2019-02-20 11:41:45
@article{ad96358c-329e-4f80-82fa-d39efe894997,
  abstract     = {<p>Background: Osteonecrosis of the lunate, Kienböck's disease, can lead to fragmentation of the lunate, carpal collapse, and severe osteoarthritis. Since the etiology of Kienböck's disease is impaired circulation, a diagnostic method capable of assessing perfusion would be valuable. Recent studies have suggested that dynamic contrast-enhanced (DCE) MR examinations at 3 T can assess perfusion in healthy carpal bones. Purpose: To evaluate the use of DCE-MR for assessing perfusion in the lunate bone in patients with Kienböck's disease. Furthermore, to compare perfusion with histopathology with a focus on bone viability. Study Type: Prospective case–control study. Population: Fourteen patients with Kienböck's disease and a control group of 19 healthy subjects. Field Strength: 3 T with T<sub>1</sub>-weighted fat-saturated contrast-enhanced gradient echo series. Assessment: Features of the enhancement curves from the DCE-MR examinations, time to peak (TTP), maximum slope (MS), and maximum enhancement (ME) assessed by a radiologist. Six of 14 patients were surgerized with lunate excision, allowing comparison between features of the enhancement curves and histopathology. Statistical Tests: Mann–Whitney U-test. P &lt; 0.05 was considered a statistically significant difference. Results: Patients with Kienböck's disease showed significantly higher and faster perfusion parameters compared with the control group, the mean value of the TTP in patients was 126.73 sec, in controls 189.79 sec (P = 0.024), ME in patients 173.55 AU, in controls 28.46 AU (P &lt; 0.001), and MS in patients 5.04 AU, in controls 1.06 AU (P &lt; 0.001). When compared with histopathology, increased perfusion was seen in areas of bone formation but also in necrosis. Areas of normal bone showed low perfusion. Data Conclusion: DCE-MRI at 3 T can diagnose altered perfusion in patients with Kienböck's disease. Increased perfusion cannot definitely be used as a marker of bone viability. Level of Evidence: 1. Technical Efficacy: Stage 3. J. Magn. Reson. Imaging 2018.</p>},
  author       = {Müller, Gunilla and Månsson, Sven and Müller, Markus F. and Johansson, Martin and Björkman, Anders},
  issn         = {1053-1807},
  keyword      = {dynamic MRI,histology,Kienböck's disease,lunate,viability},
  language     = {eng},
  month        = {12},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Magnetic Resonance Imaging},
  title        = {Increased perfusion in dynamic gadolinium-enhanced MRI correlates with areas of bone repair and of bone necrosis in patients with Kienböck's disease},
  url          = {http://dx.doi.org/10.1002/jmri.26573},
  year         = {2018},
}