Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Anithiactin D, a Phenylthiazole Natural Product from Mudflat-Derived Streptomyces sp., Suppresses Motility of Cancer Cells

Pulat, Sultan ; Yang, Inho ; Lee, Jihye ; Hwang, Sunghoon ; Zhou, Rui ; Gamage, Chathurika D B ; Varlı, Mücahit ; Taş, İsa LU orcid ; Yang, Yi and Park, So-Yeon , et al. (2024) In Marine Drugs 22(2).
Abstract

Anithiactin D (1), a 2-phenylthiazole class of natural products, was isolated from marine mudflat-derived actinomycetes Streptomyces sp. 10A085. The chemical structure of 1 was elucidated based on the interpretation of NMR and MS data. The absolute configuration of 1 was determined by comparing the experimental and calculated electronic circular dichroism (ECD) spectral data. Anithiactin D (1) significantly decreased cancer cell migration and invasion activities at a concentration of 5 μM via downregulation of the epithelial-to-mesenchymal transition (EMT) markers in A549, AGS, and Caco-2 cell lines. Moreover, 1 inhibited the activity of Rho GTPases, including Rac1 and RhoA in the A549 cell line, suppressed RhoA in AGS and Caco-2 cell... (More)

Anithiactin D (1), a 2-phenylthiazole class of natural products, was isolated from marine mudflat-derived actinomycetes Streptomyces sp. 10A085. The chemical structure of 1 was elucidated based on the interpretation of NMR and MS data. The absolute configuration of 1 was determined by comparing the experimental and calculated electronic circular dichroism (ECD) spectral data. Anithiactin D (1) significantly decreased cancer cell migration and invasion activities at a concentration of 5 μM via downregulation of the epithelial-to-mesenchymal transition (EMT) markers in A549, AGS, and Caco-2 cell lines. Moreover, 1 inhibited the activity of Rho GTPases, including Rac1 and RhoA in the A549 cell line, suppressed RhoA in AGS and Caco-2 cell lines, and decreased the mRNA expression levels of some matrix metalloproteinases (MMPs) in AGS and Caco-2 cell lines. Thus 1, which is a new entity of the 2-phenylthiazole class of natural products with a unique aniline-indole fused moiety, is a potent inhibitor of the motility of cancer cells.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
publishing date
type
Contribution to journal
publication status
published
keywords
Humans, Cell Line, Tumor, Caco-2 Cells, Streptomyces/metabolism, A549 Cells, rho GTP-Binding Proteins/metabolism, Cell Movement, Epithelial-Mesenchymal Transition, Neoplasms
in
Marine Drugs
volume
22
issue
2
article number
88
publisher
MDPI AG
external identifiers
  • scopus:85185858219
  • pmid:38393059
ISSN
1660-3397
DOI
10.3390/md22020088
language
English
LU publication?
no
id
ada39f73-1c4a-4f01-bbe8-00e0a695d3c1
date added to LUP
2026-09-23 16:00:40
date last changed
2026-09-24 04:01:34
@article{ada39f73-1c4a-4f01-bbe8-00e0a695d3c1,
  abstract     = {{<p>Anithiactin D (1), a 2-phenylthiazole class of natural products, was isolated from marine mudflat-derived actinomycetes Streptomyces sp. 10A085. The chemical structure of 1 was elucidated based on the interpretation of NMR and MS data. The absolute configuration of 1 was determined by comparing the experimental and calculated electronic circular dichroism (ECD) spectral data. Anithiactin D (1) significantly decreased cancer cell migration and invasion activities at a concentration of 5 μM via downregulation of the epithelial-to-mesenchymal transition (EMT) markers in A549, AGS, and Caco-2 cell lines. Moreover, 1 inhibited the activity of Rho GTPases, including Rac1 and RhoA in the A549 cell line, suppressed RhoA in AGS and Caco-2 cell lines, and decreased the mRNA expression levels of some matrix metalloproteinases (MMPs) in AGS and Caco-2 cell lines. Thus 1, which is a new entity of the 2-phenylthiazole class of natural products with a unique aniline-indole fused moiety, is a potent inhibitor of the motility of cancer cells.</p>}},
  author       = {{Pulat, Sultan and Yang, Inho and Lee, Jihye and Hwang, Sunghoon and Zhou, Rui and Gamage, Chathurika D B and Varlı, Mücahit and Taş, İsa and Yang, Yi and Park, So-Yeon and Hong, Ahreum and Kim, Jeong-Hyeon and Oh, Dong-Chan and Kim, Hangun and Nam, Sang-Jip and Kang, Heonjoong}},
  issn         = {{1660-3397}},
  keywords     = {{Humans; Cell Line, Tumor; Caco-2 Cells; Streptomyces/metabolism; A549 Cells; rho GTP-Binding Proteins/metabolism; Cell Movement; Epithelial-Mesenchymal Transition; Neoplasms}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{2}},
  publisher    = {{MDPI AG}},
  series       = {{Marine Drugs}},
  title        = {{Anithiactin D, a Phenylthiazole Natural Product from Mudflat-Derived Streptomyces sp., Suppresses Motility of Cancer Cells}},
  url          = {{http://dx.doi.org/10.3390/md22020088}},
  doi          = {{10.3390/md22020088}},
  volume       = {{22}},
  year         = {{2024}},
}