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Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma.

Mahmutovic Persson, Irma LU orcid ; Akbarshahi, Hamid LU ; Bartlett, N W ; Glanville, N ; Johnston, S L ; Brandelius, Angelica LU and Uller, Lena LU (2014) In Allergy 69(3). p.348-358
Abstract
Rhinovirus infection or dsRNA stimulation increased thymic stromal lymphopoietin (TSLP), an upstream pro-allergic cytokine, in asthmatic bronchial epithelial cells. We hypothesized that dsRNA challenges superimposed on established experimental allergic asthma constitute a useful exacerbation model. We further hypothesized that TSLP is induced at dsRNA- and rhinoviral infection-induced exacerbations.
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Allergy
volume
69
issue
3
pages
348 - 358
publisher
Wiley-Blackwell
external identifiers
  • pmid:24283976
  • wos:000331358400008
  • scopus:84894267969
  • pmid:24283976
ISSN
1398-9995
DOI
10.1111/all.12329
language
English
LU publication?
yes
id
ae2164bf-c191-4267-a6bb-5898e6bcc015 (old id 4178864)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24283976?dopt=Abstract
date added to LUP
2016-04-01 10:52:51
date last changed
2025-10-14 11:55:22
@article{ae2164bf-c191-4267-a6bb-5898e6bcc015,
  abstract     = {{Rhinovirus infection or dsRNA stimulation increased thymic stromal lymphopoietin (TSLP), an upstream pro-allergic cytokine, in asthmatic bronchial epithelial cells. We hypothesized that dsRNA challenges superimposed on established experimental allergic asthma constitute a useful exacerbation model. We further hypothesized that TSLP is induced at dsRNA- and rhinoviral infection-induced exacerbations.}},
  author       = {{Mahmutovic Persson, Irma and Akbarshahi, Hamid and Bartlett, N W and Glanville, N and Johnston, S L and Brandelius, Angelica and Uller, Lena}},
  issn         = {{1398-9995}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{348--358}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Allergy}},
  title        = {{Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma.}},
  url          = {{http://dx.doi.org/10.1111/all.12329}},
  doi          = {{10.1111/all.12329}},
  volume       = {{69}},
  year         = {{2014}},
}