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Repeat procedures for recurrent colorectal liver metastases : Analysis of long-term liver regeneration and outcome

Valdimarsson, Valentinus T. LU ; Hellberg, Katarina ; Brismar, Torkel B. ; Sparrelid, Ernesto and Sturesson, Christian LU (2019) In Cancer Management and Research 11. p.2617-2622
Abstract

Background and aim: Repeat hepatectomy is increasingly performed for the management of recurrent colorectal liver metastases (CRLM). The aim of this study was to evaluate longterm functional liver volume (FLV) after a second hepatic procedure and to measure survival outcome. Methods: In this retrospective cohort study, patients treated for recurrent CRLM in the years 2005-2015 at two liver centers were included. Total FLV was calculated before the first procedure and before and after the second procedure. Overall survival was calculated. Results: Eighty-two patients were identified. The median follow-up was 53 (40-71) months from the first procedure. The median interval between first and second procedure was 13 (8-22) months. The... (More)

Background and aim: Repeat hepatectomy is increasingly performed for the management of recurrent colorectal liver metastases (CRLM). The aim of this study was to evaluate longterm functional liver volume (FLV) after a second hepatic procedure and to measure survival outcome. Methods: In this retrospective cohort study, patients treated for recurrent CRLM in the years 2005-2015 at two liver centers were included. Total FLV was calculated before the first procedure and before and after the second procedure. Overall survival was calculated. Results: Eighty-two patients were identified. The median follow-up was 53 (40-71) months from the first procedure. The median interval between first and second procedure was 13 (8-22) months. The initial FLV was 1584 (1313-1927) mL. The FLV was 1438 (1204-1896) mL after the first procedure and 1470 (1172-1699) mL after the second procedure (P<0.001). After the second procedure, a total of ten patients (12%) had a residual liver volume of less than 75% of the initial liver volume. The 5-year overall survival was 37 (26-54)% after the second procedure. Conclusion: Small changes in FLV were found after two hepatic procedures but with considerable inter-individual variation. Patients selected for a repeated hepatic procedure for recurrent CRLM had an acceptable survival.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Colorectal cancer, Liver metastases, Liver regeneration, Postoperative outcomes, Repeat hepatectomy
in
Cancer Management and Research
volume
11
pages
6 pages
publisher
Dove Medical Press Ltd.
external identifiers
  • pmid:31118767
  • scopus:85065066080
ISSN
1179-1322
DOI
10.2147/CMAR.S191653
language
English
LU publication?
yes
id
ae255fe8-f434-4578-8547-e39c0c64cc3c
date added to LUP
2019-05-17 13:18:14
date last changed
2020-10-27 01:36:29
@article{ae255fe8-f434-4578-8547-e39c0c64cc3c,
  abstract     = {<p>Background and aim: Repeat hepatectomy is increasingly performed for the management of recurrent colorectal liver metastases (CRLM). The aim of this study was to evaluate longterm functional liver volume (FLV) after a second hepatic procedure and to measure survival outcome. Methods: In this retrospective cohort study, patients treated for recurrent CRLM in the years 2005-2015 at two liver centers were included. Total FLV was calculated before the first procedure and before and after the second procedure. Overall survival was calculated. Results: Eighty-two patients were identified. The median follow-up was 53 (40-71) months from the first procedure. The median interval between first and second procedure was 13 (8-22) months. The initial FLV was 1584 (1313-1927) mL. The FLV was 1438 (1204-1896) mL after the first procedure and 1470 (1172-1699) mL after the second procedure (P&lt;0.001). After the second procedure, a total of ten patients (12%) had a residual liver volume of less than 75% of the initial liver volume. The 5-year overall survival was 37 (26-54)% after the second procedure. Conclusion: Small changes in FLV were found after two hepatic procedures but with considerable inter-individual variation. Patients selected for a repeated hepatic procedure for recurrent CRLM had an acceptable survival.</p>},
  author       = {Valdimarsson, Valentinus T. and Hellberg, Katarina and Brismar, Torkel B. and Sparrelid, Ernesto and Sturesson, Christian},
  issn         = {1179-1322},
  language     = {eng},
  pages        = {2617--2622},
  publisher    = {Dove Medical Press Ltd.},
  series       = {Cancer Management and Research},
  title        = {Repeat procedures for recurrent colorectal liver metastases : Analysis of long-term liver regeneration and outcome},
  url          = {http://dx.doi.org/10.2147/CMAR.S191653},
  doi          = {10.2147/CMAR.S191653},
  volume       = {11},
  year         = {2019},
}