Association Between Prenatal and Early Postnatal Exposure to Perfluoroalkyl Substances and IQ Score in 7-Year-Old Children From the Odense Child Cohort
Have Beck, Iben ; Bilenberg, Niels ; Möller, Sören ; Nielsen, Flemming ; Grandjean, Philippe ; Damsgaard Hojsager, Frederik ; Ingi Halldorsson, Thorhallur ; Nielsen, Christel LU
and Kold Jensen, Tina
(2023)
In American Journal of Epidemiology
192(9).
p.1522-1535
- Abstract
- Perfluoroalkyl substances (PFAS) are persistent chemicals capable of crossing the placenta and passing into breast milk. Evidence suggests that PFAS exposure may affect brain development. We investigated whether prenatal or early postnatal PFAS exposure was associated with intelligence quotient (IQ) scores in schoolchildren from the Odense Child Cohort (Denmark, 2010–2020). We assessed concentrations of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) in maternal serum collected during the first trimester of pregnancy and in child serum at age 18 months. At 7 years of age, children completed an abbreviated version of... (More)
- Perfluoroalkyl substances (PFAS) are persistent chemicals capable of crossing the placenta and passing into breast milk. Evidence suggests that PFAS exposure may affect brain development. We investigated whether prenatal or early postnatal PFAS exposure was associated with intelligence quotient (IQ) scores in schoolchildren from the Odense Child Cohort (Denmark, 2010–2020). We assessed concentrations of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) in maternal serum collected during the first trimester of pregnancy and in child serum at age 18 months. At 7 years of age, children completed an abbreviated version of the Wechsler Intelligence Scale for Children, Fifth Edition, from which Full Scale Intelligence Quotient (FSIQ) and Verbal Comprehension Index scores were estimated. In multiple linear regression analyses conducted among 967 mother-child pairs, a doubling in maternal PFOS and PFNA concentrations was associated with a lower FSIQ score, while no significant associations were observed for PFOA, PFHxS, or PFDA. PFAS concentrations at age 18 months and duration of breastfeeding were strongly correlated, and even in structural equation models it was not possible to differentiate between the opposite effects of PFAS exposure and duration of breastfeeding on FSIQ. PFAS exposure is ubiquitous; therefore, an association with even a small reduction in IQ is of public health concern. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/ae3c373d-8d80-483b-85fd-3e032fc2bf82
- author
- Have Beck, Iben
; Bilenberg, Niels
; Möller, Sören
; Nielsen, Flemming
; Grandjean, Philippe
; Damsgaard Hojsager, Frederik
; Ingi Halldorsson, Thorhallur
; Nielsen, Christel
LU
and Kold Jensen, Tina
- organization
- publishing date
- 2023-09-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Journal of Epidemiology
- volume
- 192
- issue
- 9
- pages
- 1522 - 1535
- publisher
- Oxford University Press
- external identifiers
-
- pmid:37119029
- scopus:85162108728
- ISSN
- 0002-9262
- DOI
- 10.1093/aje/kwad110
- language
- English
- LU publication?
- yes
- id
- ae3c373d-8d80-483b-85fd-3e032fc2bf82
- date added to LUP
- 2023-09-04 17:14:26
- date last changed
- 2023-11-22 04:11:04
@article{ae3c373d-8d80-483b-85fd-3e032fc2bf82,
abstract = {{Perfluoroalkyl substances (PFAS) are persistent chemicals capable of crossing the placenta and passing into breast milk. Evidence suggests that PFAS exposure may affect brain development. We investigated whether prenatal or early postnatal PFAS exposure was associated with intelligence quotient (IQ) scores in schoolchildren from the Odense Child Cohort (Denmark, 2010–2020). We assessed concentrations of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) in maternal serum collected during the first trimester of pregnancy and in child serum at age 18 months. At 7 years of age, children completed an abbreviated version of the Wechsler Intelligence Scale for Children, Fifth Edition, from which Full Scale Intelligence Quotient (FSIQ) and Verbal Comprehension Index scores were estimated. In multiple linear regression analyses conducted among 967 mother-child pairs, a doubling in maternal PFOS and PFNA concentrations was associated with a lower FSIQ score, while no significant associations were observed for PFOA, PFHxS, or PFDA. PFAS concentrations at age 18 months and duration of breastfeeding were strongly correlated, and even in structural equation models it was not possible to differentiate between the opposite effects of PFAS exposure and duration of breastfeeding on FSIQ. PFAS exposure is ubiquitous; therefore, an association with even a small reduction in IQ is of public health concern.}},
author = {{Have Beck, Iben and Bilenberg, Niels and Möller, Sören and Nielsen, Flemming and Grandjean, Philippe and Damsgaard Hojsager, Frederik and Ingi Halldorsson, Thorhallur and Nielsen, Christel and Kold Jensen, Tina}},
issn = {{0002-9262}},
language = {{eng}},
month = {{09}},
number = {{9}},
pages = {{1522--1535}},
publisher = {{Oxford University Press}},
series = {{American Journal of Epidemiology}},
title = {{Association Between Prenatal and Early Postnatal Exposure to Perfluoroalkyl Substances and IQ Score in 7-Year-Old Children From the Odense Child Cohort}},
url = {{http://dx.doi.org/10.1093/aje/kwad110}},
doi = {{10.1093/aje/kwad110}},
volume = {{192}},
year = {{2023}},
}