Evolution of the Cdk-activator Speedy/RINGO in vertebrates
Chauhan, Sangeeta ; Zheng, Xinde ; Tan, Yue Ying ; Tay, Boon Hui ; Lim, Shuhui ; Venkatesh, Byrappa and Kaldis, Philipp LU
(2012)
In Cellular and Molecular Life Sciences
69(22).
p.3835-3850
- Abstract
Successful completion of the cell cycle relies on the precise activation and inactivation of cyclindependent kinases (Cdks) whose activity is mainly regulated by binding to cyclins. Recently, a new family of Cdk regulators termed Speedy/RINGO has been discovered, which can bind and activate Cdks but shares no apparent amino acid sequence homology with cyclins. All Speedy proteins share a conserved domain of approximately 140 amino acids called ''Speedy Box'', which is essential for Cdk binding. Speedy/RINGO proteins display an important role in oocyte maturation in Xenopus. Interestingly, a common feature of all Speedy genes is their predominant expression in testis suggesting that meiotic functions may be the most important... (More)
Successful completion of the cell cycle relies on the precise activation and inactivation of cyclindependent kinases (Cdks) whose activity is mainly regulated by binding to cyclins. Recently, a new family of Cdk regulators termed Speedy/RINGO has been discovered, which can bind and activate Cdks but shares no apparent amino acid sequence homology with cyclins. All Speedy proteins share a conserved domain of approximately 140 amino acids called ''Speedy Box'', which is essential for Cdk binding. Speedy/RINGO proteins display an important role in oocyte maturation in Xenopus. Interestingly, a common feature of all Speedy genes is their predominant expression in testis suggesting that meiotic functions may be the most important physiological feature of Speedy genes. Speedy homologs have been reported in mammals and can be traced back to the most primitive clade of chordates (Ciona intestinalis). Here, we investigated the evolution of the Speedy genes and have identified a number of new Speedy/RINGO proteins. Through extensive analysis of numerous species, we discovered diverse evolutionary histories: the number of Speedy genes varies considerably among species, with evidence of substantial gains and losses. Despite the interspecies variation, Speedy is conserved among most species examined. Our results provide a complete picture of the Speedy gene family and its evolution.
(Less)
- author
- Chauhan, Sangeeta
; Zheng, Xinde
; Tan, Yue Ying
; Tay, Boon Hui
; Lim, Shuhui
; Venkatesh, Byrappa
and Kaldis, Philipp
LU
- publishing date
- 2012-11-01
- type
- Contribution to journal
- publication status
- published
- in
- Cellular and Molecular Life Sciences
- volume
- 69
- issue
- 22
- pages
- 3835 - 3850
- publisher
- Birkhäuser Verlag
- external identifiers
-
- scopus:84867879462
- pmid:22763696
- ISSN
- 1420-682X
- DOI
- 10.1007/s00018-012-1050-1
- language
- English
- LU publication?
- no
- id
- ae6151c5-17a2-40e0-bd7a-e3bb5d56404e
- date added to LUP
- 2019-09-18 13:58:02
- date last changed
- 2024-07-24 06:13:47
@article{ae6151c5-17a2-40e0-bd7a-e3bb5d56404e,
abstract = {{<p>Successful completion of the cell cycle relies on the precise activation and inactivation of cyclindependent kinases (Cdks) whose activity is mainly regulated by binding to cyclins. Recently, a new family of Cdk regulators termed Speedy/RINGO has been discovered, which can bind and activate Cdks but shares no apparent amino acid sequence homology with cyclins. All Speedy proteins share a conserved domain of approximately 140 amino acids called ''Speedy Box'', which is essential for Cdk binding. Speedy/RINGO proteins display an important role in oocyte maturation in Xenopus. Interestingly, a common feature of all Speedy genes is their predominant expression in testis suggesting that meiotic functions may be the most important physiological feature of Speedy genes. Speedy homologs have been reported in mammals and can be traced back to the most primitive clade of chordates (Ciona intestinalis). Here, we investigated the evolution of the Speedy genes and have identified a number of new Speedy/RINGO proteins. Through extensive analysis of numerous species, we discovered diverse evolutionary histories: the number of Speedy genes varies considerably among species, with evidence of substantial gains and losses. Despite the interspecies variation, Speedy is conserved among most species examined. Our results provide a complete picture of the Speedy gene family and its evolution.</p>}},
author = {{Chauhan, Sangeeta and Zheng, Xinde and Tan, Yue Ying and Tay, Boon Hui and Lim, Shuhui and Venkatesh, Byrappa and Kaldis, Philipp}},
issn = {{1420-682X}},
language = {{eng}},
month = {{11}},
number = {{22}},
pages = {{3835--3850}},
publisher = {{Birkhäuser Verlag}},
series = {{Cellular and Molecular Life Sciences}},
title = {{Evolution of the Cdk-activator Speedy/RINGO in vertebrates}},
url = {{http://dx.doi.org/10.1007/s00018-012-1050-1}},
doi = {{10.1007/s00018-012-1050-1}},
volume = {{69}},
year = {{2012}},
}