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Molecular Convergent Evolution of the MYBPC2 Gene Among Three High-Elevation Amphibian Species

Yang, Weizhao LU ; Lu, Bin and Fu, Jinzhong (2017) In Journal of Molecular Evolution 84(2-3). p.139-143
Abstract

We report a strong pattern of molecular-level convergent/parallel evolution of the MYBPC2 gene. Three high-elevation amphibian species, Bufo gargarizans minshanicus, Nanorana pleskei, Rana kukunoris, revealed remarkable numbers of convergent and parallel amino acid substitutions. On the MYBPC2 gene tree of eleven anurans, the three distantly related species formed a strongly supported clade that was away from their respective relatives. Furthermore, we generated both model-based and empirical data-based null distributions for neutral convergent evolution. All three pairwise comparisons among the three species showed significantly more convergent and parallel substitutions than the null distributions. This study adds to the very small... (More)

We report a strong pattern of molecular-level convergent/parallel evolution of the MYBPC2 gene. Three high-elevation amphibian species, Bufo gargarizans minshanicus, Nanorana pleskei, Rana kukunoris, revealed remarkable numbers of convergent and parallel amino acid substitutions. On the MYBPC2 gene tree of eleven anurans, the three distantly related species formed a strongly supported clade that was away from their respective relatives. Furthermore, we generated both model-based and empirical data-based null distributions for neutral convergent evolution. All three pairwise comparisons among the three species showed significantly more convergent and parallel substitutions than the null distributions. This study adds to the very small roster of clear cases of non-neutral molecular convergent evolution (e.g. prestin, rhodopsin). Molecular convergent evolution has significant implications in biology and detailed case studies will likely provide more insight into its genetic mechanisms.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Amphibian, Case-study, Molecular convergence, MYBPC2 gene
in
Journal of Molecular Evolution
volume
84
issue
2-3
pages
139 - 143
publisher
Springer
external identifiers
  • scopus:85013150619
  • wos:000398294900007
ISSN
0022-2844
DOI
10.1007/s00239-017-9782-z
language
English
LU publication?
yes
id
ae6f1fd6-5b7c-489f-9944-1dc7bd673f66
date added to LUP
2017-03-01 09:09:42
date last changed
2018-02-20 10:46:00
@article{ae6f1fd6-5b7c-489f-9944-1dc7bd673f66,
  abstract     = {<p>We report a strong pattern of molecular-level convergent/parallel evolution of the MYBPC2 gene. Three high-elevation amphibian species, Bufo gargarizans minshanicus, Nanorana pleskei, Rana kukunoris, revealed remarkable numbers of convergent and parallel amino acid substitutions. On the MYBPC2 gene tree of eleven anurans, the three distantly related species formed a strongly supported clade that was away from their respective relatives. Furthermore, we generated both model-based and empirical data-based null distributions for neutral convergent evolution. All three pairwise comparisons among the three species showed significantly more convergent and parallel substitutions than the null distributions. This study adds to the very small roster of clear cases of non-neutral molecular convergent evolution (e.g. prestin, rhodopsin). Molecular convergent evolution has significant implications in biology and detailed case studies will likely provide more insight into its genetic mechanisms.</p>},
  author       = {Yang, Weizhao and Lu, Bin and Fu, Jinzhong},
  issn         = {0022-2844},
  keyword      = {Amphibian,Case-study,Molecular convergence,MYBPC2 gene},
  language     = {eng},
  number       = {2-3},
  pages        = {139--143},
  publisher    = {Springer},
  series       = {Journal of Molecular Evolution},
  title        = {Molecular Convergent Evolution of the MYBPC2 Gene Among Three High-Elevation Amphibian Species},
  url          = {http://dx.doi.org/10.1007/s00239-017-9782-z},
  volume       = {84},
  year         = {2017},
}