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Bone mineral as a drug-seeking moiety and a waste dump a Review

Raina, D. B. LU ; Liu, Y. LU ; Jacobson, Otto L.P. ; Tägil, M. LU ; Lidgren, L. LU and Tanner, K. E. (2020) In Bone and Joint Research 9(10). p.709-718
Abstract

Bone is a dynamic tissue with a quarter of the trabecular and a fifth of the cortical bone being replaced continuously each year in a complex process that continues throughout an individual’s lifetime. Bone has an important role in homeostasis of minerals with non-stoichiometric hydroxyapatite bone mineral forming the inorganic phase of bone. Due to its crystal structure and chemistry, hydroxyapatite (HA) and related apatites have a remarkable ability to bind molecules. This review article describes the accretion of trace elements in bone mineral giving a historical perspective. Implanted HA particles of synthetic origin have proved to be an efficient recruiting moiety for systemically circulating drugs which can locally biomodulate the... (More)

Bone is a dynamic tissue with a quarter of the trabecular and a fifth of the cortical bone being replaced continuously each year in a complex process that continues throughout an individual’s lifetime. Bone has an important role in homeostasis of minerals with non-stoichiometric hydroxyapatite bone mineral forming the inorganic phase of bone. Due to its crystal structure and chemistry, hydroxyapatite (HA) and related apatites have a remarkable ability to bind molecules. This review article describes the accretion of trace elements in bone mineral giving a historical perspective. Implanted HA particles of synthetic origin have proved to be an efficient recruiting moiety for systemically circulating drugs which can locally biomodulate the material and lead to a therapeutic effect. Bone mineral and apatite however also act as a waste dump for trace elements and drugs, which significantly affects the environment and human health.

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Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antibiotics, Bone infection, Bone mineral, Hydroxyapatite, Waste dump
in
Bone and Joint Research
volume
9
issue
10
pages
10 pages
publisher
British Editorial Society of Bone & Joint Surgery
external identifiers
  • pmid:33399475
  • scopus:85095577653
ISSN
2046-3758
DOI
10.1302/2046-3758.910.BJR-2020-0097.R1
language
English
LU publication?
yes
id
ae76e372-7e9f-4fb0-856b-2ce81bf53d06
date added to LUP
2021-01-08 12:43:07
date last changed
2024-03-20 22:46:30
@article{ae76e372-7e9f-4fb0-856b-2ce81bf53d06,
  abstract     = {{<p>Bone is a dynamic tissue with a quarter of the trabecular and a fifth of the cortical bone being replaced continuously each year in a complex process that continues throughout an individual’s lifetime. Bone has an important role in homeostasis of minerals with non-stoichiometric hydroxyapatite bone mineral forming the inorganic phase of bone. Due to its crystal structure and chemistry, hydroxyapatite (HA) and related apatites have a remarkable ability to bind molecules. This review article describes the accretion of trace elements in bone mineral giving a historical perspective. Implanted HA particles of synthetic origin have proved to be an efficient recruiting moiety for systemically circulating drugs which can locally biomodulate the material and lead to a therapeutic effect. Bone mineral and apatite however also act as a waste dump for trace elements and drugs, which significantly affects the environment and human health.</p>}},
  author       = {{Raina, D. B. and Liu, Y. and Jacobson, Otto L.P. and Tägil, M. and Lidgren, L. and Tanner, K. E.}},
  issn         = {{2046-3758}},
  keywords     = {{Antibiotics; Bone infection; Bone mineral; Hydroxyapatite; Waste dump}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{709--718}},
  publisher    = {{British Editorial Society of Bone & Joint Surgery}},
  series       = {{Bone and Joint Research}},
  title        = {{Bone mineral as a drug-seeking moiety and a waste dump a Review}},
  url          = {{http://dx.doi.org/10.1302/2046-3758.910.BJR-2020-0097.R1}},
  doi          = {{10.1302/2046-3758.910.BJR-2020-0097.R1}},
  volume       = {{9}},
  year         = {{2020}},
}