Bone mineral as a drug-seeking moiety and a waste dump a Review
(2020) In Bone and Joint Research 9(10). p.709-718- Abstract
Bone is a dynamic tissue with a quarter of the trabecular and a fifth of the cortical bone being replaced continuously each year in a complex process that continues throughout an individual’s lifetime. Bone has an important role in homeostasis of minerals with non-stoichiometric hydroxyapatite bone mineral forming the inorganic phase of bone. Due to its crystal structure and chemistry, hydroxyapatite (HA) and related apatites have a remarkable ability to bind molecules. This review article describes the accretion of trace elements in bone mineral giving a historical perspective. Implanted HA particles of synthetic origin have proved to be an efficient recruiting moiety for systemically circulating drugs which can locally biomodulate the... (More)
Bone is a dynamic tissue with a quarter of the trabecular and a fifth of the cortical bone being replaced continuously each year in a complex process that continues throughout an individual’s lifetime. Bone has an important role in homeostasis of minerals with non-stoichiometric hydroxyapatite bone mineral forming the inorganic phase of bone. Due to its crystal structure and chemistry, hydroxyapatite (HA) and related apatites have a remarkable ability to bind molecules. This review article describes the accretion of trace elements in bone mineral giving a historical perspective. Implanted HA particles of synthetic origin have proved to be an efficient recruiting moiety for systemically circulating drugs which can locally biomodulate the material and lead to a therapeutic effect. Bone mineral and apatite however also act as a waste dump for trace elements and drugs, which significantly affects the environment and human health.
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- author
- Raina, D. B. LU ; Liu, Y. LU ; Jacobson, Otto L.P. ; Tägil, M. LU ; Lidgren, L. LU and Tanner, K. E.
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Antibiotics, Bone infection, Bone mineral, Hydroxyapatite, Waste dump
- in
- Bone and Joint Research
- volume
- 9
- issue
- 10
- pages
- 10 pages
- publisher
- British Editorial Society of Bone & Joint Surgery
- external identifiers
-
- pmid:33399475
- scopus:85095577653
- ISSN
- 2046-3758
- DOI
- 10.1302/2046-3758.910.BJR-2020-0097.R1
- language
- English
- LU publication?
- yes
- id
- ae76e372-7e9f-4fb0-856b-2ce81bf53d06
- date added to LUP
- 2021-01-08 12:43:07
- date last changed
- 2024-03-20 22:46:30
@article{ae76e372-7e9f-4fb0-856b-2ce81bf53d06, abstract = {{<p>Bone is a dynamic tissue with a quarter of the trabecular and a fifth of the cortical bone being replaced continuously each year in a complex process that continues throughout an individual’s lifetime. Bone has an important role in homeostasis of minerals with non-stoichiometric hydroxyapatite bone mineral forming the inorganic phase of bone. Due to its crystal structure and chemistry, hydroxyapatite (HA) and related apatites have a remarkable ability to bind molecules. This review article describes the accretion of trace elements in bone mineral giving a historical perspective. Implanted HA particles of synthetic origin have proved to be an efficient recruiting moiety for systemically circulating drugs which can locally biomodulate the material and lead to a therapeutic effect. Bone mineral and apatite however also act as a waste dump for trace elements and drugs, which significantly affects the environment and human health.</p>}}, author = {{Raina, D. B. and Liu, Y. and Jacobson, Otto L.P. and Tägil, M. and Lidgren, L. and Tanner, K. E.}}, issn = {{2046-3758}}, keywords = {{Antibiotics; Bone infection; Bone mineral; Hydroxyapatite; Waste dump}}, language = {{eng}}, number = {{10}}, pages = {{709--718}}, publisher = {{British Editorial Society of Bone & Joint Surgery}}, series = {{Bone and Joint Research}}, title = {{Bone mineral as a drug-seeking moiety and a waste dump a Review}}, url = {{http://dx.doi.org/10.1302/2046-3758.910.BJR-2020-0097.R1}}, doi = {{10.1302/2046-3758.910.BJR-2020-0097.R1}}, volume = {{9}}, year = {{2020}}, }