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Urinary Tract Infections and the Mucosal Immune System

Ambite, Ines LU orcid ; Lutay, Nataliya LU ; Godaly, Gabriela LU orcid and Svanborg, Catharina LU (2015) 2. p.2039-2058
Abstract

Urinary tract infections offer an important and highly relevant model to understand innate immune-mediated protection against mucosal infection and innate immune genetics of susceptibility, including promoter polymorphisms reducing Toll-like receptor (TLR) and interferon regulatory factor expression. Whereas virulent Escherichia coli causes severe, potentially life-threatening disease by breaking the inertia of the mucosal barrier, the most common outcome of bacteriuria is an asymptomatic carrier state (ABU) resembling commensalism at other mucosal sites. Pathogens gain a short-term advantage by expressing virulence factors that dysregulate a range of innate signaling pathways and effector functions, including molecules that inactivate... (More)

Urinary tract infections offer an important and highly relevant model to understand innate immune-mediated protection against mucosal infection and innate immune genetics of susceptibility, including promoter polymorphisms reducing Toll-like receptor (TLR) and interferon regulatory factor expression. Whereas virulent Escherichia coli causes severe, potentially life-threatening disease by breaking the inertia of the mucosal barrier, the most common outcome of bacteriuria is an asymptomatic carrier state (ABU) resembling commensalism at other mucosal sites. Pathogens gain a short-term advantage by expressing virulence factors that dysregulate a range of innate signaling pathways and effector functions, including molecules that inactivate TLR signaling. Genome sequencing has revealed that ABU strains, in contrast, have evolved by reductive evolution with a loss of virulence genes and gain of a new class of host RNA polymerase II suppressive activity. These extremes illustrate aspects of "good" versus "bad" inflammation, pathology versus symbiosis. Novel therapeutic approaches based on these molecular interactions are discussed.

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Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Host genetics, Innate immunity, Mucosal immunity, Pathogen specificity, Therapy, Urinary tract infection
host publication
Mucosal Immunology
volume
2
edition
4
pages
2039 - 2058
publisher
Mosby-Elsevier
external identifiers
  • scopus:84939542765
ISBN
9780124159754
9780124158474
DOI
10.1016/B978-0-12-415847-4.00106-3
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2015 Elsevier Inc. All rights reserved.
id
ae901242-b065-4cd3-b981-6455cbf85390
date added to LUP
2026-09-22 16:07:53
date last changed
2026-10-07 15:14:01
@inbook{ae901242-b065-4cd3-b981-6455cbf85390,
  abstract     = {{<p>Urinary tract infections offer an important and highly relevant model to understand innate immune-mediated protection against mucosal infection and innate immune genetics of susceptibility, including promoter polymorphisms reducing Toll-like receptor (TLR) and interferon regulatory factor expression. Whereas virulent Escherichia coli causes severe, potentially life-threatening disease by breaking the inertia of the mucosal barrier, the most common outcome of bacteriuria is an asymptomatic carrier state (ABU) resembling commensalism at other mucosal sites. Pathogens gain a short-term advantage by expressing virulence factors that dysregulate a range of innate signaling pathways and effector functions, including molecules that inactivate TLR signaling. Genome sequencing has revealed that ABU strains, in contrast, have evolved by reductive evolution with a loss of virulence genes and gain of a new class of host RNA polymerase II suppressive activity. These extremes illustrate aspects of "good" versus "bad" inflammation, pathology versus symbiosis. Novel therapeutic approaches based on these molecular interactions are discussed.</p>}},
  author       = {{Ambite, Ines and Lutay, Nataliya and Godaly, Gabriela and Svanborg, Catharina}},
  booktitle    = {{Mucosal Immunology}},
  isbn         = {{9780124159754}},
  keywords     = {{Host genetics; Innate immunity; Mucosal immunity; Pathogen specificity; Therapy; Urinary tract infection}},
  language     = {{eng}},
  month        = {{04}},
  pages        = {{2039--2058}},
  publisher    = {{Mosby-Elsevier}},
  title        = {{Urinary Tract Infections and the Mucosal Immune System}},
  url          = {{http://dx.doi.org/10.1016/B978-0-12-415847-4.00106-3}},
  doi          = {{10.1016/B978-0-12-415847-4.00106-3}},
  volume       = {{2}},
  year         = {{2015}},
}