Extracellular matrix structure.
(2015) In Advanced Drug Delivery Reviews- Abstract
- Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins, and several other glycoproteins. Matrix components bind each other as well as cell to adhesion receptors forming a complex network into which cells reside in all tissues and organs. Cell surface receptors transduce signals into cells from ECM, which regulate diverse cellular functions, such as survival, growth, migration, and differentiation and are vital for maintaining normal homeostasis. ECM is a highly dynamic structural network that continuously undergoes remodeling mediated by several matrix-degrading enzymes during normal and pathological conditions.... (More)
- Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins, and several other glycoproteins. Matrix components bind each other as well as cell to adhesion receptors forming a complex network into which cells reside in all tissues and organs. Cell surface receptors transduce signals into cells from ECM, which regulate diverse cellular functions, such as survival, growth, migration, and differentiation and are vital for maintaining normal homeostasis. ECM is a highly dynamic structural network that continuously undergoes remodeling mediated by several matrix-degrading enzymes during normal and pathological conditions. Deregulation of ECM composition and structure is associated with the development and progression of several pathologic conditions. This article emphasizes in the complex ECM structure as to provide a better understanding of its dynamic structural and functional multipotency. Where relevant, the implication of the various families of ECM macromolecules in health and disease is also presented. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8235702
- author
- Theocharis, Achilleas D ; Skandalis, Spyros S ; Gialeli, Chrysostomi LU and Karamanos, Nikos K
- organization
- publishing date
- 2015-11-10
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Advanced Drug Delivery Reviews
- publisher
- Elsevier
- external identifiers
-
- pmid:26562801
- scopus:84957808678
- wos:000370906200002
- pmid:26562801
- ISSN
- 0169-409X
- DOI
- 10.1016/j.addr.2015.11.001
- language
- English
- LU publication?
- yes
- id
- af0c5a08-9845-48dc-8950-1e803c33e013 (old id 8235702)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26562801?dopt=Abstract
- date added to LUP
- 2016-04-04 08:56:42
- date last changed
- 2022-05-16 22:07:16
@article{af0c5a08-9845-48dc-8950-1e803c33e013,
abstract = {{Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins, and several other glycoproteins. Matrix components bind each other as well as cell to adhesion receptors forming a complex network into which cells reside in all tissues and organs. Cell surface receptors transduce signals into cells from ECM, which regulate diverse cellular functions, such as survival, growth, migration, and differentiation and are vital for maintaining normal homeostasis. ECM is a highly dynamic structural network that continuously undergoes remodeling mediated by several matrix-degrading enzymes during normal and pathological conditions. Deregulation of ECM composition and structure is associated with the development and progression of several pathologic conditions. This article emphasizes in the complex ECM structure as to provide a better understanding of its dynamic structural and functional multipotency. Where relevant, the implication of the various families of ECM macromolecules in health and disease is also presented.}},
author = {{Theocharis, Achilleas D and Skandalis, Spyros S and Gialeli, Chrysostomi and Karamanos, Nikos K}},
issn = {{0169-409X}},
language = {{eng}},
month = {{11}},
publisher = {{Elsevier}},
series = {{Advanced Drug Delivery Reviews}},
title = {{Extracellular matrix structure.}},
url = {{http://dx.doi.org/10.1016/j.addr.2015.11.001}},
doi = {{10.1016/j.addr.2015.11.001}},
year = {{2015}},
}