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Gamma Oryzanol Treats Obesity-Induced Kidney Injuries by Modulating the Adiponectin Receptor 2/PPAR-α Axis

Francisqueti, Fabiane Valentini ; Ferron, Artur Junio Togneri ; Hasimoto, Fabiana Kurokawa ; Alves, Pedro Henrique Rizzi ; Garcia, Jéssica Leite ; Dos Santos, Klinsmann Carolo LU ; Moreto, Fernando ; Silva, Vanessa Dos Santos ; Ferreira, Ana Lúcia A. and Minatel, Igor Otávio , et al. (2018) In Oxidative Medicine and Cellular Longevity 2018.
Abstract

The kidney is an important organ in the maintenance of body homeostasis. Dietary compounds, reactive metabolites, obesity, and metabolic syndrome (MetS) can affect renal filtration and whole body homeostasis, increasing the risk of chronic kidney disease (CKD) development. Gamma oryzanol (γOz) is a compound with antioxidant and anti-inflammatory activity that has shown a positive action in the treatment of obesity and metabolic diseases. Aim. To evaluate the effect of γOz to recover renal function in obese animals by high sugar-fat diet by modulation of adiponectin receptor 2/PPAR-α axis Methods. Male Wistar rats were initially randomly divided into 2 experimental groups: control and high sugar-fat diet (HSF) for 20 weeks. When... (More)

The kidney is an important organ in the maintenance of body homeostasis. Dietary compounds, reactive metabolites, obesity, and metabolic syndrome (MetS) can affect renal filtration and whole body homeostasis, increasing the risk of chronic kidney disease (CKD) development. Gamma oryzanol (γOz) is a compound with antioxidant and anti-inflammatory activity that has shown a positive action in the treatment of obesity and metabolic diseases. Aim. To evaluate the effect of γOz to recover renal function in obese animals by high sugar-fat diet by modulation of adiponectin receptor 2/PPAR-α axis Methods. Male Wistar rats were initially randomly divided into 2 experimental groups: control and high sugar-fat diet (HSF) for 20 weeks. When proteinuria was detected, HSF animals were allocated to receive γOz or maintain HSF for more than 10 weeks. The following were analyzed: nutritional and biochemical parameters, systolic blood pressure, and renal function. In the kidney, the following were evaluated: inflammation, oxidative stress, and protein expression by Western blot. Results. After 10 weeks of γOz treatment, γOz was effective to improve inflammation, increase antioxidant enzyme activities, increase the protein expression of adiponectin receptor 2 and PPAR-α, and recover renal function. Conclusion. These results permit us to confirm that γOz is able to modulate PPAR-α expression, inflammation, and oxidative stress pathways improving obesity-induced renal disease.

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publishing date
type
Contribution to journal
publication status
published
subject
in
Oxidative Medicine and Cellular Longevity
volume
2018
pages
1 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:30271526
  • scopus:85054358411
ISSN
1942-0900
DOI
10.1155/2018/1278392
language
English
LU publication?
no
id
afdd7e15-022b-4982-be89-17a95edcfa06
date added to LUP
2019-03-28 15:19:44
date last changed
2025-06-13 05:54:03
@article{afdd7e15-022b-4982-be89-17a95edcfa06,
  abstract     = {{<p>The kidney is an important organ in the maintenance of body homeostasis. Dietary compounds, reactive metabolites, obesity, and metabolic syndrome (MetS) can affect renal filtration and whole body homeostasis, increasing the risk of chronic kidney disease (CKD) development. Gamma oryzanol (γOz) is a compound with antioxidant and anti-inflammatory activity that has shown a positive action in the treatment of obesity and metabolic diseases. Aim. To evaluate the effect of γOz to recover renal function in obese animals by high sugar-fat diet by modulation of adiponectin receptor 2/PPAR-α axis Methods. Male Wistar rats were initially randomly divided into 2 experimental groups: control and high sugar-fat diet (HSF) for 20 weeks. When proteinuria was detected, HSF animals were allocated to receive γOz or maintain HSF for more than 10 weeks. The following were analyzed: nutritional and biochemical parameters, systolic blood pressure, and renal function. In the kidney, the following were evaluated: inflammation, oxidative stress, and protein expression by Western blot. Results. After 10 weeks of γOz treatment, γOz was effective to improve inflammation, increase antioxidant enzyme activities, increase the protein expression of adiponectin receptor 2 and PPAR-α, and recover renal function. Conclusion. These results permit us to confirm that γOz is able to modulate PPAR-α expression, inflammation, and oxidative stress pathways improving obesity-induced renal disease.</p>}},
  author       = {{Francisqueti, Fabiane Valentini and Ferron, Artur Junio Togneri and Hasimoto, Fabiana Kurokawa and Alves, Pedro Henrique Rizzi and Garcia, Jéssica Leite and Dos Santos, Klinsmann Carolo and Moreto, Fernando and Silva, Vanessa Dos Santos and Ferreira, Ana Lúcia A. and Minatel, Igor Otávio and Corrêa, Camila Renata}},
  issn         = {{1942-0900}},
  language     = {{eng}},
  month        = {{01}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Oxidative Medicine and Cellular Longevity}},
  title        = {{Gamma Oryzanol Treats Obesity-Induced Kidney Injuries by Modulating the Adiponectin Receptor 2/PPAR-α Axis}},
  url          = {{http://dx.doi.org/10.1155/2018/1278392}},
  doi          = {{10.1155/2018/1278392}},
  volume       = {{2018}},
  year         = {{2018}},
}