Preclinical Studies Design and Place of Rabbits
(2023) p.31-56- Abstract
The rabbit is a common laboratory animal used for research in dental implants, mainly as a screening model. It has many advantages compared to other laboratory animals. Availability, handling, cost-effectiveness, and early skeletal maturity are a few. For the model’s validity, there need to be similarities to the human. Although there are similarities between human and rabbit anatomy, there are also differences. These differences can make extrapolation of results difficult. In the human, dental implants are placed in the mandible and maxilla. The limited access for surgery in the mouth of the rabbit together with the low bone volume of the jawbones makes it difficult for implant placement. Extraoral sites such as tibia, femur, and the... (More)
The rabbit is a common laboratory animal used for research in dental implants, mainly as a screening model. It has many advantages compared to other laboratory animals. Availability, handling, cost-effectiveness, and early skeletal maturity are a few. For the model’s validity, there need to be similarities to the human. Although there are similarities between human and rabbit anatomy, there are also differences. These differences can make extrapolation of results difficult. In the human, dental implants are placed in the mandible and maxilla. The limited access for surgery in the mouth of the rabbit together with the low bone volume of the jawbones makes it difficult for implant placement. Extraoral sites such as tibia, femur, and the skull are frequently used instead. Remodeling and healing of the tibia resemble that of the mandible. Just like the remodeling and healing is similar in the skull and the maxilla. Surgery in the different oral and extraoral sites is presented for the purpose of being a practical introduction to surgery. Investigative methods are presented. Finally a discussion follows, including expert opinions and validity of the different implant sites, with the importance of balancing the models with ethical concerns and the possible outcome.
(Less)
- author
- Sandgren, R. LU
- organization
- publishing date
- 2023-01-01
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- Surgical Research in Implant Dentistry
- pages
- 26 pages
- publisher
- Springer International Publishing
- external identifiers
-
- scopus:85210665707
- ISBN
- 9783031372339
- 9783031372346
- DOI
- 10.1007/978-3-031-37234-6_3
- language
- English
- LU publication?
- yes
- id
- afde4989-d6ad-4e6a-bf3d-35ddb4e08d00
- date added to LUP
- 2025-03-12 14:30:32
- date last changed
- 2025-06-18 22:41:47
@inbook{afde4989-d6ad-4e6a-bf3d-35ddb4e08d00,
abstract = {{<p>The rabbit is a common laboratory animal used for research in dental implants, mainly as a screening model. It has many advantages compared to other laboratory animals. Availability, handling, cost-effectiveness, and early skeletal maturity are a few. For the model’s validity, there need to be similarities to the human. Although there are similarities between human and rabbit anatomy, there are also differences. These differences can make extrapolation of results difficult. In the human, dental implants are placed in the mandible and maxilla. The limited access for surgery in the mouth of the rabbit together with the low bone volume of the jawbones makes it difficult for implant placement. Extraoral sites such as tibia, femur, and the skull are frequently used instead. Remodeling and healing of the tibia resemble that of the mandible. Just like the remodeling and healing is similar in the skull and the maxilla. Surgery in the different oral and extraoral sites is presented for the purpose of being a practical introduction to surgery. Investigative methods are presented. Finally a discussion follows, including expert opinions and validity of the different implant sites, with the importance of balancing the models with ethical concerns and the possible outcome.</p>}},
author = {{Sandgren, R.}},
booktitle = {{Surgical Research in Implant Dentistry}},
isbn = {{9783031372339}},
language = {{eng}},
month = {{01}},
pages = {{31--56}},
publisher = {{Springer International Publishing}},
title = {{Preclinical Studies Design and Place of Rabbits}},
url = {{http://dx.doi.org/10.1007/978-3-031-37234-6_3}},
doi = {{10.1007/978-3-031-37234-6_3}},
year = {{2023}},
}