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Selenium status during pregnancy : Influential factors and effects on neuropsychological development among Spanish infants

Amorós, Rubén ; Murcia, Mario ; Ballester, Ferran ; Broberg, Karin LU orcid ; Iñiguez, Carmen ; Rebagliato, Marisa ; Skröder, Helena ; González, Llúcia ; Lopez-Espinosa, Maria-Jose and Llop, Sabrina (2018) In Science of the Total Environment 610-611. p.741-749
Abstract

Selenium (Se) has been positively associated with neurodevelopment in early life. However, its margin of safety is rather narrow, and few prospective studies have evaluated its potential neurotoxic effects at intermediate levels. We aimed to explore the association between maternal Se concentrations and child neuropsychological development, including the genetic effect modification of the Se metabolizing gene INMT. Study subjects were 650 mother-child pairs from the Spanish Childhood and Environment Project (INMA, 2003-2005). Infant neuropsychological development was assessed around 12months of age by the Bayley Scales of Infant Development. Sociodemographic and dietary characteristics were collected by questionnaire at the first and... (More)

Selenium (Se) has been positively associated with neurodevelopment in early life. However, its margin of safety is rather narrow, and few prospective studies have evaluated its potential neurotoxic effects at intermediate levels. We aimed to explore the association between maternal Se concentrations and child neuropsychological development, including the genetic effect modification of the Se metabolizing gene INMT. Study subjects were 650 mother-child pairs from the Spanish Childhood and Environment Project (INMA, 2003-2005). Infant neuropsychological development was assessed around 12months of age by the Bayley Scales of Infant Development. Sociodemographic and dietary characteristics were collected by questionnaire at the first and third trimester of gestation. Se was measured in serum samples at the first trimester. The mean serum Se concentration was 79.7 (standard deviation=7.9) μg/L. In multivariate analysis, nonsignificant inverse linear associations were found between Se concentrations and standardized mental and psychomotor development scores (β (95% CI)=-0.13 (-0.29, 0.03) and β (95% CI)=-0.08 (-0.24, 0.07), respectively). Generalized additive models indicated inverted U-shaped relationships between Se concentrations and both scales. Using segmented regression, the turning point for the associations was estimated at 86μg/L for both scales. The association between Se and neuropsychological development was inverted U-shaped for children with the AG+AA genotype for rs6970396 INMT but a descending curve was suggested for the GG genotype. Further studies would be necessary in order to disentangle the complex equilibrium between the toxicity and benefits of Se exposure during the prenatal period.

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author
; ; ; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Adult, Child Development, Female, Humans, Infant, Male, Methyltransferases/genetics, Multivariate Analysis, Pregnancy/blood, Prenatal Exposure Delayed Effects, Prospective Studies, Selenium/blood, Selenium Compounds
in
Science of the Total Environment
volume
610-611
pages
741 - 749
publisher
Elsevier
external identifiers
  • scopus:85027491896
  • pmid:28822941
ISSN
1879-1026
DOI
10.1016/j.scitotenv.2017.08.042
language
English
LU publication?
no
id
afe17fe8-fba5-4f84-9f0a-08b86e3535fb
date added to LUP
2019-02-08 13:50:13
date last changed
2025-07-09 17:16:48
@article{afe17fe8-fba5-4f84-9f0a-08b86e3535fb,
  abstract     = {{<p>Selenium (Se) has been positively associated with neurodevelopment in early life. However, its margin of safety is rather narrow, and few prospective studies have evaluated its potential neurotoxic effects at intermediate levels. We aimed to explore the association between maternal Se concentrations and child neuropsychological development, including the genetic effect modification of the Se metabolizing gene INMT. Study subjects were 650 mother-child pairs from the Spanish Childhood and Environment Project (INMA, 2003-2005). Infant neuropsychological development was assessed around 12months of age by the Bayley Scales of Infant Development. Sociodemographic and dietary characteristics were collected by questionnaire at the first and third trimester of gestation. Se was measured in serum samples at the first trimester. The mean serum Se concentration was 79.7 (standard deviation=7.9) μg/L. In multivariate analysis, nonsignificant inverse linear associations were found between Se concentrations and standardized mental and psychomotor development scores (β (95% CI)=-0.13 (-0.29, 0.03) and β (95% CI)=-0.08 (-0.24, 0.07), respectively). Generalized additive models indicated inverted U-shaped relationships between Se concentrations and both scales. Using segmented regression, the turning point for the associations was estimated at 86μg/L for both scales. The association between Se and neuropsychological development was inverted U-shaped for children with the AG+AA genotype for rs6970396 INMT but a descending curve was suggested for the GG genotype. Further studies would be necessary in order to disentangle the complex equilibrium between the toxicity and benefits of Se exposure during the prenatal period.</p>}},
  author       = {{Amorós, Rubén and Murcia, Mario and Ballester, Ferran and Broberg, Karin and Iñiguez, Carmen and Rebagliato, Marisa and Skröder, Helena and González, Llúcia and Lopez-Espinosa, Maria-Jose and Llop, Sabrina}},
  issn         = {{1879-1026}},
  keywords     = {{Adult; Child Development; Female; Humans; Infant; Male; Methyltransferases/genetics; Multivariate Analysis; Pregnancy/blood; Prenatal Exposure Delayed Effects; Prospective Studies; Selenium/blood; Selenium Compounds}},
  language     = {{eng}},
  month        = {{01}},
  pages        = {{741--749}},
  publisher    = {{Elsevier}},
  series       = {{Science of the Total Environment}},
  title        = {{Selenium status during pregnancy : Influential factors and effects on neuropsychological development among Spanish infants}},
  url          = {{http://dx.doi.org/10.1016/j.scitotenv.2017.08.042}},
  doi          = {{10.1016/j.scitotenv.2017.08.042}},
  volume       = {{610-611}},
  year         = {{2018}},
}