Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men
(2005) In Diabetes Care 28(7). p.1636-1642- Abstract
- OBJECTIVE - The goal of this study was to examine the relationship between serum testosterone levels and insulin sensitivity and mitochondrial function in men, RESEARCH DESIGN AND METHODS - A total of 60 men (mean age 60.5 +/- 1.2 years) had a detailed hormonal and metabolic evaluation. Insulin sensitivity was measured Using a hyperinsulinemic-euglycemic clamp. Mitochondrial function was assessed by measuring maximal aerobic capacity (Vo(2max)) and expression of oxidative phosphorylation gene,, in skeletal muscle, RESULTS - A total of 45% of subjects had normal glucose tolerance, 20% had impaired glucose tolerance, and 35% had type 2 diabetes. Testosterone levels were correlated with insulin sensitivity (r = 0.4, P < 0.005). Subjects... (More)
- OBJECTIVE - The goal of this study was to examine the relationship between serum testosterone levels and insulin sensitivity and mitochondrial function in men, RESEARCH DESIGN AND METHODS - A total of 60 men (mean age 60.5 +/- 1.2 years) had a detailed hormonal and metabolic evaluation. Insulin sensitivity was measured Using a hyperinsulinemic-euglycemic clamp. Mitochondrial function was assessed by measuring maximal aerobic capacity (Vo(2max)) and expression of oxidative phosphorylation gene,, in skeletal muscle, RESULTS - A total of 45% of subjects had normal glucose tolerance, 20% had impaired glucose tolerance, and 35% had type 2 diabetes. Testosterone levels were correlated with insulin sensitivity (r = 0.4, P < 0.005). Subjects with hypogonadal testosterone levels (n = 10) had a BMI > 25 kg/m(2) and a threefold higher prevalence of the metabolic syndrome than their eugonadal counterparts (n = 50) this relationship held true after adjusting for age and sex hormone-binding globulin but not BMI. Testosterone levels also correlated with (Vo(2max),11 0 = 0.43, P < 0.05) and oxidative phosphorylation gene expression (r = 0.57, P < 0.0001). CONCLUSIONS - These data indicate that low serum testosterone levels are associated with an adverse metabolic profile and suggest a novel unifying mechanism for the previously independent observations that low testosterone levels and impaired mitochondrial function promote insulin resistance in men. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/233873
- author
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes Care
- volume
- 28
- issue
- 7
- pages
- 1636 - 1642
- publisher
- American Diabetes Association
- external identifiers
-
- wos:000230163800015
- pmid:15983313
- scopus:24944450769
- ISSN
- 1935-5548
- language
- English
- LU publication?
- yes
- id
- b0040020-7e22-4f79-8c05-ac64bd97af42 (old id 233873)
- alternative location
- http://care.diabetesjournals.org/cgi/content/full/28/7/1636
- date added to LUP
- 2016-04-01 16:11:11
- date last changed
- 2024-04-25 22:58:51
@article{b0040020-7e22-4f79-8c05-ac64bd97af42, abstract = {{OBJECTIVE - The goal of this study was to examine the relationship between serum testosterone levels and insulin sensitivity and mitochondrial function in men, RESEARCH DESIGN AND METHODS - A total of 60 men (mean age 60.5 +/- 1.2 years) had a detailed hormonal and metabolic evaluation. Insulin sensitivity was measured Using a hyperinsulinemic-euglycemic clamp. Mitochondrial function was assessed by measuring maximal aerobic capacity (Vo(2max)) and expression of oxidative phosphorylation gene,, in skeletal muscle, RESULTS - A total of 45% of subjects had normal glucose tolerance, 20% had impaired glucose tolerance, and 35% had type 2 diabetes. Testosterone levels were correlated with insulin sensitivity (r = 0.4, P < 0.005). Subjects with hypogonadal testosterone levels (n = 10) had a BMI > 25 kg/m(2) and a threefold higher prevalence of the metabolic syndrome than their eugonadal counterparts (n = 50) this relationship held true after adjusting for age and sex hormone-binding globulin but not BMI. Testosterone levels also correlated with (Vo(2max),11 0 = 0.43, P < 0.05) and oxidative phosphorylation gene expression (r = 0.57, P < 0.0001). CONCLUSIONS - These data indicate that low serum testosterone levels are associated with an adverse metabolic profile and suggest a novel unifying mechanism for the previously independent observations that low testosterone levels and impaired mitochondrial function promote insulin resistance in men.}}, author = {{Pitteloud, N and Mootha, VK and Dwyer, AA and Hardin, M and Lee, H and Eriksson, Karl-Fredrik and Tripathy, Devjit and Yialamas, M and Groop, Leif and Elahi, D and Hayes, FJ}}, issn = {{1935-5548}}, language = {{eng}}, number = {{7}}, pages = {{1636--1642}}, publisher = {{American Diabetes Association}}, series = {{Diabetes Care}}, title = {{Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men}}, url = {{http://care.diabetesjournals.org/cgi/content/full/28/7/1636}}, volume = {{28}}, year = {{2005}}, }