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Synergistic effect of haloduracin and chloramphenicol against clinically important Gram-positive bacteria

Danesh, Abolghasem LU ; Ljungh, Åsa LU ; Mattiasson, Bo LU and Mamo, Gashaw LU (2017) In Biotechnology Reports 13. p.37-41
Abstract

The emergence of drug-resistant pathogens has triggered the search for more efficient antimicrobial agents and formulations for treatment of infections. In recent years, combination therapy has become one of the effective clinical practices in treating infections. The present study deals with the effect of haloduracin, a lantibiotic bateriocin and chloramphenicol against clinically important bacteria. The combined use of haloduracin and chloramphenicol resulted in remarkable synergy against a spectrum of microorganisms including strains of Staphylococcus aureus, Enterococcus faecium, Enterococcus faecalis and different groups of Streptococcus. The synergy allowed using these antimicrobial agents at substantially reduced concentrations... (More)

The emergence of drug-resistant pathogens has triggered the search for more efficient antimicrobial agents and formulations for treatment of infections. In recent years, combination therapy has become one of the effective clinical practices in treating infections. The present study deals with the effect of haloduracin, a lantibiotic bateriocin and chloramphenicol against clinically important bacteria. The combined use of haloduracin and chloramphenicol resulted in remarkable synergy against a spectrum of microorganisms including strains of Staphylococcus aureus, Enterococcus faecium, Enterococcus faecalis and different groups of Streptococcus. The synergy allowed using these antimicrobial agents at substantially reduced concentrations without compromising their efficiency. Use of lower doses of chloramphenicol can avoid the severity of its side effects. In addition to minimizing undesirable side effects of some drugs, this approach brings the possibility of using antibiotics that are no longer effective due to drug resistance. Furthermore, the observed synergy between haloduracin and chloramphenicol opens a new window of using bacteriocins and antibiotics in combination therapy of infections.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Chloramphenicol, Combination therapy, Drug resistance, Haloduracin, Topical antibiotics
in
Biotechnology Reports
volume
13
pages
5 pages
publisher
Elsevier
external identifiers
  • scopus:85009205124
ISSN
2215-017X
DOI
10.1016/j.btre.2016.12.008
language
English
LU publication?
yes
id
b021d76c-cac1-477a-9f51-05493ecb287f
date added to LUP
2017-02-03 08:32:03
date last changed
2018-01-07 11:47:54
@article{b021d76c-cac1-477a-9f51-05493ecb287f,
  abstract     = {<p>The emergence of drug-resistant pathogens has triggered the search for more efficient antimicrobial agents and formulations for treatment of infections. In recent years, combination therapy has become one of the effective clinical practices in treating infections. The present study deals with the effect of haloduracin, a lantibiotic bateriocin and chloramphenicol against clinically important bacteria. The combined use of haloduracin and chloramphenicol resulted in remarkable synergy against a spectrum of microorganisms including strains of Staphylococcus aureus, Enterococcus faecium, Enterococcus faecalis and different groups of Streptococcus. The synergy allowed using these antimicrobial agents at substantially reduced concentrations without compromising their efficiency. Use of lower doses of chloramphenicol can avoid the severity of its side effects. In addition to minimizing undesirable side effects of some drugs, this approach brings the possibility of using antibiotics that are no longer effective due to drug resistance. Furthermore, the observed synergy between haloduracin and chloramphenicol opens a new window of using bacteriocins and antibiotics in combination therapy of infections.</p>},
  author       = {Danesh, Abolghasem and Ljungh, Åsa and Mattiasson, Bo and Mamo, Gashaw},
  issn         = {2215-017X},
  keyword      = {Chloramphenicol,Combination therapy,Drug resistance,Haloduracin,Topical antibiotics},
  language     = {eng},
  month        = {03},
  pages        = {37--41},
  publisher    = {Elsevier},
  series       = {Biotechnology Reports},
  title        = {Synergistic effect of haloduracin and chloramphenicol against clinically important Gram-positive bacteria},
  url          = {http://dx.doi.org/10.1016/j.btre.2016.12.008},
  volume       = {13},
  year         = {2017},
}