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Which patients with moderate hypoxemia benefit from long-term oxygen therapy? Ways forward

Ekström, Magnus LU and Ringbaek, Thomas (2018) In International Journal of COPD 13. p.231-235
Abstract

Long-term oxygen therapy (LTOT) improves prognosis in patients with COPD and chronic severe hypoxemia. The efficacy in moderate hypoxemia (tension of arterial oxygen; on air, 7.4−8.0 kPa) was questioned by a recent large trial. We reviewed the evidence to date (five randomized trials; 1,191 participants, all with COPD). Based on the current evidence, the survival time may be improved in patients with moderate hypoxemia with secondary polycythemia or right-sided heart failure, but not in the absence of these signs. Clinically, LTOT is not indicated in moderate hypoxemia except in the few patients with polycythemia or signs of right-sided heart failure, which may reflect more chronic and severe hypoxemia.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
COPD, Hypoxemia, Oxygen therapy, Survival
in
International Journal of COPD
volume
13
pages
5 pages
publisher
Dove Press
external identifiers
  • scopus:85040923967
ISSN
1176-9106
DOI
10.2147/COPD.S148673
language
English
LU publication?
yes
id
b03790b9-5bad-4164-b475-8aa470e077b7
date added to LUP
2018-02-23 18:43:02
date last changed
2018-05-29 11:45:51
@article{b03790b9-5bad-4164-b475-8aa470e077b7,
  abstract     = {<p>Long-term oxygen therapy (LTOT) improves prognosis in patients with COPD and chronic severe hypoxemia. The efficacy in moderate hypoxemia (tension of arterial oxygen; on air, 7.4−8.0 kPa) was questioned by a recent large trial. We reviewed the evidence to date (five randomized trials; 1,191 participants, all with COPD). Based on the current evidence, the survival time may be improved in patients with moderate hypoxemia with secondary polycythemia or right-sided heart failure, but not in the absence of these signs. Clinically, LTOT is not indicated in moderate hypoxemia except in the few patients with polycythemia or signs of right-sided heart failure, which may reflect more chronic and severe hypoxemia.</p>},
  author       = {Ekström, Magnus and Ringbaek, Thomas},
  issn         = {1176-9106},
  keyword      = {COPD,Hypoxemia,Oxygen therapy,Survival},
  language     = {eng},
  month        = {01},
  pages        = {231--235},
  publisher    = {Dove Press},
  series       = {International Journal of COPD},
  title        = {Which patients with moderate hypoxemia benefit from long-term oxygen therapy? Ways forward},
  url          = {http://dx.doi.org/10.2147/COPD.S148673},
  volume       = {13},
  year         = {2018},
}