Advanced

Normal Distribution and Plasticity of Serotonin Receptors after Spinal Cord Injury and Their Impacts on Motor Outputs

Zhang, Mengliang LU (2016) In Recovery of Motor Function Following Spinal Cord Injury p.95-95
Abstract
Following spinal cord injury (SCI) a series of anatomical and functional plastic changes occur in the spinal cord, including reorganization of the spinal neuronal network, alteration of properties of interneurons and motoneurons as well as up- or down-regulation of different neurotransmitter receptors. In mammalian spinal cord, one of the important neurotransmitters, serotonin (5-HT), plays an essential role in modulating sensory, motor and autonomic functions. Following SCI, especially complete spinal cord lesion, the descending supply of 5-HT is lost. As a consequence different 5-HT receptors undergo variant degrees of plastic changes.

In this chapter I have systematically reviewed the distribution of different 5-HT receptors in... (More)
Following spinal cord injury (SCI) a series of anatomical and functional plastic changes occur in the spinal cord, including reorganization of the spinal neuronal network, alteration of properties of interneurons and motoneurons as well as up- or down-regulation of different neurotransmitter receptors. In mammalian spinal cord, one of the important neurotransmitters, serotonin (5-HT), plays an essential role in modulating sensory, motor and autonomic functions. Following SCI, especially complete spinal cord lesion, the descending supply of 5-HT is lost. As a consequence different 5-HT receptors undergo variant degrees of plastic changes.

In this chapter I have systematically reviewed the distribution of different 5-HT receptors in the spinal cord and their plastic changes following SCI where applicable. In addition, the plastic changes of 5-HT supplying system in reaction to SCI have also been reviewed. These results indicate that 5-HT receptors are important factors not only for modulation of normal motor function, their plastic changes are also critical for motor functional recovery and, quite often, for the development of certain pathological states after SCI. Pharmacological and/or genetic intervention of selected 5-HT receptors and/or intrinsic 5-HT producing system in the spinal cord may pave new ways for the restoration of motor functions after SCI. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Monoamine, monoamine receptor, spinal cord, motor control, intraspinal 5-HT cell
in
Recovery of Motor Function Following Spinal Cord Injury
editor
Fuller, Heidi; Gates, Monte; and
pages
135 pages
ISBN
978-953-51-2497-9
978-953-51-2498-6
DOI
10.5772/63759
language
English
LU publication?
yes
id
b0514c2c-ac24-4e92-af5b-7f55619d9575
date added to LUP
2017-07-13 11:08:35
date last changed
2017-07-26 11:58:29
@inbook{b0514c2c-ac24-4e92-af5b-7f55619d9575,
  abstract     = {Following spinal cord injury (SCI) a series of anatomical and functional plastic changes occur in the spinal cord, including reorganization of the spinal neuronal network, alteration of properties of interneurons and motoneurons as well as up- or down-regulation of different neurotransmitter receptors. In mammalian spinal cord, one of the important neurotransmitters, serotonin (5-HT), plays an essential role in modulating sensory, motor and autonomic functions. Following SCI, especially complete spinal cord lesion, the descending supply of 5-HT is lost. As a consequence different 5-HT receptors undergo variant degrees of plastic changes.<br/><br/>In this chapter I have systematically reviewed the distribution of different 5-HT receptors in the spinal cord and their plastic changes following SCI where applicable. In addition, the plastic changes of 5-HT supplying system in reaction to SCI have also been reviewed. These results indicate that 5-HT receptors are important factors not only for modulation of normal motor function, their plastic changes are also critical for motor functional recovery and, quite often, for the development of certain pathological states after SCI. Pharmacological and/or genetic intervention of selected 5-HT receptors and/or intrinsic 5-HT producing system in the spinal cord may pave new ways for the restoration of motor functions after SCI.},
  author       = {Zhang, Mengliang},
  editor       = {Fuller, Heidi and  Gates, Monte},
  isbn         = {978-953-51-2497-9},
  keyword      = {Monoamine,monoamine receptor,spinal cord,motor control,intraspinal 5-HT cell},
  language     = {eng},
  month        = {08},
  pages        = {95--95},
  series       = { Recovery of Motor Function Following Spinal Cord Injury},
  title        = {Normal Distribution and Plasticity of Serotonin Receptors after Spinal Cord Injury and Their Impacts on Motor Outputs},
  url          = {http://dx.doi.org/10.5772/63759},
  year         = {2016},
}