Total adiponectin does not predict cardiovascular events in middle-aged men in a prospective, long-term follow-up study
(2010) In Diabetes & Metabolism 36(2). p.137-143- Abstract
- Aim. Plasma total adiponectin is a marker of insulin resistance, but its role in predicting cardiovascular events is unclear. We aimed to investigate the role of adiponectin as a predictor of cardiovascular risk in middle-aged men, and to describe the association between adiponectin and glucose metabolism. Methods. In this population-based prospective study of middle-aged men (n=3885), total adiponectin was analyzed. All individuals had undergone an oral glucose tolerance test (OGTTs), and the mean follow-up duration was 27 years. Regression analyses were carried out for indices of glucose metabolism in relation to quintiles (Q1-Q5) of total aliponectin levels. After stratification for smoking or not, the association between total... (More)
- Aim. Plasma total adiponectin is a marker of insulin resistance, but its role in predicting cardiovascular events is unclear. We aimed to investigate the role of adiponectin as a predictor of cardiovascular risk in middle-aged men, and to describe the association between adiponectin and glucose metabolism. Methods. In this population-based prospective study of middle-aged men (n=3885), total adiponectin was analyzed. All individuals had undergone an oral glucose tolerance test (OGTTs), and the mean follow-up duration was 27 years. Regression analyses were carried out for indices of glucose metabolism in relation to quintiles (Q1-Q5) of total aliponectin levels. After stratification for smoking or not, the association between total adiponectin and the first incidence of fatal or non-fatal cardiovascular disease (CVD) was analyzed, using Cox's proportional-hazards regression model. Results. In a separate multiple-regression analysis and after adjusting for possible confounders, the relationship between adiponectin levels and markers of glucose metabolism were found to be significant (P<0.05). However, adiponectin did not independently predict the risk of stroke, coronary events, or a combination of these two outcomes. Conclusion. Levels of total plasma adiponectin are not useful for predicting long-term cardiovascular events in middle-aged men, but are strongly associated with glucose metabolism and markers of insulin resistance. (c) 2010 Elsevier Masson SAS. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1617576
- author
- Khalili, P. ; Flyvbjerg, A. ; Frystyk, J. ; Lundin, F. ; Jendle, J. ; Engström, Gunnar LU and Nilsson, Peter LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- metabolism, Glucose, Coronary events, Adiponectin, Cardiovascular events, Stroke, Prospective study, Long-term
- in
- Diabetes & Metabolism
- volume
- 36
- issue
- 2
- pages
- 137 - 143
- publisher
- Elsevier Masson SAS
- external identifiers
-
- wos:000277835800007
- scopus:77953286453
- pmid:20153676
- ISSN
- 1878-1780
- DOI
- 10.1016/j.diabet.2009.10.004
- language
- English
- LU publication?
- yes
- id
- b0515351-34d2-46f2-9c61-be0cd4f74a1c (old id 1617576)
- date added to LUP
- 2016-04-01 14:35:51
- date last changed
- 2022-01-28 01:30:24
@article{b0515351-34d2-46f2-9c61-be0cd4f74a1c,
abstract = {{Aim. Plasma total adiponectin is a marker of insulin resistance, but its role in predicting cardiovascular events is unclear. We aimed to investigate the role of adiponectin as a predictor of cardiovascular risk in middle-aged men, and to describe the association between adiponectin and glucose metabolism. Methods. In this population-based prospective study of middle-aged men (n=3885), total adiponectin was analyzed. All individuals had undergone an oral glucose tolerance test (OGTTs), and the mean follow-up duration was 27 years. Regression analyses were carried out for indices of glucose metabolism in relation to quintiles (Q1-Q5) of total aliponectin levels. After stratification for smoking or not, the association between total adiponectin and the first incidence of fatal or non-fatal cardiovascular disease (CVD) was analyzed, using Cox's proportional-hazards regression model. Results. In a separate multiple-regression analysis and after adjusting for possible confounders, the relationship between adiponectin levels and markers of glucose metabolism were found to be significant (P<0.05). However, adiponectin did not independently predict the risk of stroke, coronary events, or a combination of these two outcomes. Conclusion. Levels of total plasma adiponectin are not useful for predicting long-term cardiovascular events in middle-aged men, but are strongly associated with glucose metabolism and markers of insulin resistance. (c) 2010 Elsevier Masson SAS. All rights reserved.}},
author = {{Khalili, P. and Flyvbjerg, A. and Frystyk, J. and Lundin, F. and Jendle, J. and Engström, Gunnar and Nilsson, Peter}},
issn = {{1878-1780}},
keywords = {{metabolism; Glucose; Coronary events; Adiponectin; Cardiovascular events; Stroke; Prospective study; Long-term}},
language = {{eng}},
number = {{2}},
pages = {{137--143}},
publisher = {{Elsevier Masson SAS}},
series = {{Diabetes & Metabolism}},
title = {{Total adiponectin does not predict cardiovascular events in middle-aged men in a prospective, long-term follow-up study}},
url = {{http://dx.doi.org/10.1016/j.diabet.2009.10.004}},
doi = {{10.1016/j.diabet.2009.10.004}},
volume = {{36}},
year = {{2010}},
}