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Survival and risk of vascular complications in myelofibrosis—A population-based study from the Swedish MPN group

Lindgren, Marie ; Andréasson, Björn ; Samuelsson, Jan ; Pettersson, Helna ; Enblom-Larsson, Anneli ; Ravn-Landtblom, Anna ; Scheding, Stefan LU ; Bentham, Carolina and Ahlstrand, Erik (2022) In European Journal of Haematology 109(4). p.336-342
Abstract

Objective: To gain knowledge of underlying risk factors for vascular complications and their impact on life expectancy in myelofibrosis. Methods: From a cohort of 392 myelofibrosis patients registered in the Swedish MPN registry 58 patients with vascular complications during follow-up were identified. Patients with vascular complications were compared with both 1:1 matched controls and the entire myelofibrosis cohort to explore potential risk factors for vascular complications and their impact on survival. Results: Incidence of vascular complications was 2.8 events per 100 patient-years and the majority of complications were thrombotic. Patients with complications were significantly older and had lower hemoglobin when compared to the... (More)

Objective: To gain knowledge of underlying risk factors for vascular complications and their impact on life expectancy in myelofibrosis. Methods: From a cohort of 392 myelofibrosis patients registered in the Swedish MPN registry 58 patients with vascular complications during follow-up were identified. Patients with vascular complications were compared with both 1:1 matched controls and the entire myelofibrosis cohort to explore potential risk factors for vascular complications and their impact on survival. Results: Incidence of vascular complications was 2.8 events per 100 patient-years and the majority of complications were thrombotic. Patients with complications were significantly older and had lower hemoglobin when compared to the entire cohort. In the case–control analysis, no significant risk factor differences were observed. The major cause of death was vascular complications and median survival was significantly impaired in patients with vascular complications (48 months) compared to controls (92 months). Inferior survival in patients with vascular complications was found to be dependent on IPSS risk category in a Cox regression model. Conclusion: Vascular complications have a considerable impact on survival in MF. At diagnosis, risk assessment by IPSS does not only predict survival but is also associated with the risk of vascular complications.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
IPSS, JAK2V617F, Myelofibrosis, myeloproliferative neoplasms, survival, vascular complications
in
European Journal of Haematology
volume
109
issue
4
pages
7 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:35696444
  • scopus:85132576366
ISSN
0902-4441
DOI
10.1111/ejh.13813
language
English
LU publication?
yes
id
b06a9e06-e56d-4fb7-b601-06b92e2c3525
date added to LUP
2022-09-27 11:41:59
date last changed
2024-04-18 14:27:25
@article{b06a9e06-e56d-4fb7-b601-06b92e2c3525,
  abstract     = {{<p>Objective: To gain knowledge of underlying risk factors for vascular complications and their impact on life expectancy in myelofibrosis. Methods: From a cohort of 392 myelofibrosis patients registered in the Swedish MPN registry 58 patients with vascular complications during follow-up were identified. Patients with vascular complications were compared with both 1:1 matched controls and the entire myelofibrosis cohort to explore potential risk factors for vascular complications and their impact on survival. Results: Incidence of vascular complications was 2.8 events per 100 patient-years and the majority of complications were thrombotic. Patients with complications were significantly older and had lower hemoglobin when compared to the entire cohort. In the case–control analysis, no significant risk factor differences were observed. The major cause of death was vascular complications and median survival was significantly impaired in patients with vascular complications (48 months) compared to controls (92 months). Inferior survival in patients with vascular complications was found to be dependent on IPSS risk category in a Cox regression model. Conclusion: Vascular complications have a considerable impact on survival in MF. At diagnosis, risk assessment by IPSS does not only predict survival but is also associated with the risk of vascular complications.</p>}},
  author       = {{Lindgren, Marie and Andréasson, Björn and Samuelsson, Jan and Pettersson, Helna and Enblom-Larsson, Anneli and Ravn-Landtblom, Anna and Scheding, Stefan and Bentham, Carolina and Ahlstrand, Erik}},
  issn         = {{0902-4441}},
  keywords     = {{IPSS; JAK2V617F; Myelofibrosis; myeloproliferative neoplasms; survival; vascular complications}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{336--342}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{European Journal of Haematology}},
  title        = {{Survival and risk of vascular complications in myelofibrosis—A population-based study from the Swedish MPN group}},
  url          = {{http://dx.doi.org/10.1111/ejh.13813}},
  doi          = {{10.1111/ejh.13813}},
  volume       = {{109}},
  year         = {{2022}},
}