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Diverse roles for CDK-associated activity during spermatogenesis

Palmer, Nathan ; Talib, S Zakiah A and Kaldis, Philipp LU (2019) In FEBS Letters 593(20). p.2925-2949
Abstract

The primary function of cyclin-dependent kinases (CDKs) in complex with their activating cyclin partners, is to promote mitotic division in somatic cells. This canonical cell cycle-associated activity is also crucial for fertility as it allows the proliferation and differentiation of stem cells within the reproductive organs to generate meiotically competent cells. Intriguingly several CDKs exhibit meiosis-specific functions and are essential for the completion of the two reductional meiotic divisions required to generate haploid gametes. These meiosis-specific functions are mediated by both known CDK/cyclin complexes and meiosis-specific CDK-regulators and are important for a variety of processes during meiotic prophase. The majority... (More)

The primary function of cyclin-dependent kinases (CDKs) in complex with their activating cyclin partners, is to promote mitotic division in somatic cells. This canonical cell cycle-associated activity is also crucial for fertility as it allows the proliferation and differentiation of stem cells within the reproductive organs to generate meiotically competent cells. Intriguingly several CDKs exhibit meiosis-specific functions and are essential for the completion of the two reductional meiotic divisions required to generate haploid gametes. These meiosis-specific functions are mediated by both known CDK/cyclin complexes and meiosis-specific CDK-regulators and are important for a variety of processes during meiotic prophase. The majority of meiotic defects observed upon deletion of these proteins occur during the extended prophase I of the first meiotic division. Importantly a lack of redundancy is seen within the meiotic arrest phenotypes described for many of these proteins suggesting intricate layers of cell cycle control are required for normal meiotic progression. Using the process of male germ cell development (spermatogenesis) as a reference, this review seeks to highlight the diverse roles of selected CDKs their activators, and their regulators during gametogenesis.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
FEBS Letters
volume
593
issue
20
pages
2925 - 2949
publisher
Wiley-Blackwell
external identifiers
  • scopus:85074185002
  • pmid:31566717
ISSN
1873-3468
DOI
10.1002/1873-3468.13627
language
English
LU publication?
yes
id
b06cb228-cd02-4e41-9980-35a83dcb6bc4
date added to LUP
2019-10-02 10:08:28
date last changed
2019-11-13 05:41:26
@article{b06cb228-cd02-4e41-9980-35a83dcb6bc4,
  abstract     = {<p>The primary function of cyclin-dependent kinases (CDKs) in complex with their activating cyclin partners, is to promote mitotic division in somatic cells. This canonical cell cycle-associated activity is also crucial for fertility as it allows the proliferation and differentiation of stem cells within the reproductive organs to generate meiotically competent cells. Intriguingly several CDKs exhibit meiosis-specific functions and are essential for the completion of the two reductional meiotic divisions required to generate haploid gametes. These meiosis-specific functions are mediated by both known CDK/cyclin complexes and meiosis-specific CDK-regulators and are important for a variety of processes during meiotic prophase. The majority of meiotic defects observed upon deletion of these proteins occur during the extended prophase I of the first meiotic division. Importantly a lack of redundancy is seen within the meiotic arrest phenotypes described for many of these proteins suggesting intricate layers of cell cycle control are required for normal meiotic progression. Using the process of male germ cell development (spermatogenesis) as a reference, this review seeks to highlight the diverse roles of selected CDKs their activators, and their regulators during gametogenesis.</p>},
  author       = {Palmer, Nathan and Talib, S Zakiah A and Kaldis, Philipp},
  issn         = {1873-3468},
  language     = {eng},
  number       = {20},
  pages        = {2925--2949},
  publisher    = {Wiley-Blackwell},
  series       = {FEBS Letters},
  title        = {Diverse roles for CDK-associated activity during spermatogenesis},
  url          = {http://dx.doi.org/10.1002/1873-3468.13627},
  doi          = {10.1002/1873-3468.13627},
  volume       = {593},
  year         = {2019},
}