The relationship between prostate-specific antigen and prostate cancer risk : The prostate biopsy collaborative group
(2010) In Clinical Cancer Research 16(17). p.4374-4381- Abstract
Purpose: The relationship between prostate-specific antigen (PSA) level and prostate cancer risk remains subject to fundamental disagreements. We hypothesized that the risk of prostate cancer on biopsy for a given PSA level is affected by identifiable characteristics of the cohort under study. Experimental Design: We used data from five European and three U.S. cohorts of men undergoing biopsy for prostate cancer; six were population-based studies and two were clinical cohorts. The association between PSA and prostate cancer was calculated separately for each cohort using locally weighted scatterplot smoothing. Results: The final data set included 25,772 biopsies and 8,503 cancers. There were gross disparities between cohorts with... (More)
Purpose: The relationship between prostate-specific antigen (PSA) level and prostate cancer risk remains subject to fundamental disagreements. We hypothesized that the risk of prostate cancer on biopsy for a given PSA level is affected by identifiable characteristics of the cohort under study. Experimental Design: We used data from five European and three U.S. cohorts of men undergoing biopsy for prostate cancer; six were population-based studies and two were clinical cohorts. The association between PSA and prostate cancer was calculated separately for each cohort using locally weighted scatterplot smoothing. Results: The final data set included 25,772 biopsies and 8,503 cancers. There were gross disparities between cohorts with respect to both the prostate cancer risk at a given PSA level and the shape of the risk curve. These disparities were associated with identifiable differences between cohorts: for a given PSA level, a greater number of biopsy cores increased the risk of cancer (odds ratio for >6- versus 6-core biopsy, 1.35; 95% confidence interval, 1.18-1.54; P < 0.0005); recent screening led to a smaller increase in risk per unit change in PSA (P = 0.001 for interaction term) and U.S. cohorts had higher risk than the European cohorts (2.14; 95% confidence interval, 1.99-2.30; P < 0.0005). Conclusions: Our results suggest that the relationship between PSA and risk of a positive prostate biopsy varies, both in terms of the probability of prostate cancer at a given PSA value and the shape of the risk curve. This poses challenges to the use of PSA-driven algorithms to determine whether biopsy is indicated.
(Less)
- author
- Vickers, Andrew J.
; Cronin, Angel M.
; Roobol, Monique J.
; Hugosson, Jonas
; Jones, J. Stephen
; Kattan, Michael W.
; Klein, Eric
; Hamdy, Freddie
; Neal, David
; Donovan, Jenny
; Parekh, Dipen J.
; Ankerst, Donna
; Bartsch, George
; Klocker, Helmut
; Horninger, Wolfgang
; Benchikh, Amine
; Salama, Gilles
; Villers, Arnauld
; Freedland, Steve J.
; Moreira, Daniel M.
; Schröder, Fritz H.
and Lilja, Hans
LU
(Less) - publishing date
- 2010-09-01
- type
- Contribution to journal
- publication status
- published
- in
- Clinical Cancer Research
- volume
- 16
- issue
- 17
- pages
- 4374 - 4381
- publisher
- American Association for Cancer Research
- external identifiers
-
- scopus:77956255132
- pmid:20736330
- ISSN
- 1078-0432
- DOI
- 10.1158/1078-0432.CCR-10-1328
- language
- English
- LU publication?
- no
- id
- b0759ff9-a487-4781-94f8-385730b8a149
- date added to LUP
- 2022-12-06 15:41:06
- date last changed
- 2024-04-04 12:11:22
@article{b0759ff9-a487-4781-94f8-385730b8a149,
abstract = {{<p>Purpose: The relationship between prostate-specific antigen (PSA) level and prostate cancer risk remains subject to fundamental disagreements. We hypothesized that the risk of prostate cancer on biopsy for a given PSA level is affected by identifiable characteristics of the cohort under study. Experimental Design: We used data from five European and three U.S. cohorts of men undergoing biopsy for prostate cancer; six were population-based studies and two were clinical cohorts. The association between PSA and prostate cancer was calculated separately for each cohort using locally weighted scatterplot smoothing. Results: The final data set included 25,772 biopsies and 8,503 cancers. There were gross disparities between cohorts with respect to both the prostate cancer risk at a given PSA level and the shape of the risk curve. These disparities were associated with identifiable differences between cohorts: for a given PSA level, a greater number of biopsy cores increased the risk of cancer (odds ratio for >6- versus 6-core biopsy, 1.35; 95% confidence interval, 1.18-1.54; P < 0.0005); recent screening led to a smaller increase in risk per unit change in PSA (P = 0.001 for interaction term) and U.S. cohorts had higher risk than the European cohorts (2.14; 95% confidence interval, 1.99-2.30; P < 0.0005). Conclusions: Our results suggest that the relationship between PSA and risk of a positive prostate biopsy varies, both in terms of the probability of prostate cancer at a given PSA value and the shape of the risk curve. This poses challenges to the use of PSA-driven algorithms to determine whether biopsy is indicated.</p>}},
author = {{Vickers, Andrew J. and Cronin, Angel M. and Roobol, Monique J. and Hugosson, Jonas and Jones, J. Stephen and Kattan, Michael W. and Klein, Eric and Hamdy, Freddie and Neal, David and Donovan, Jenny and Parekh, Dipen J. and Ankerst, Donna and Bartsch, George and Klocker, Helmut and Horninger, Wolfgang and Benchikh, Amine and Salama, Gilles and Villers, Arnauld and Freedland, Steve J. and Moreira, Daniel M. and Schröder, Fritz H. and Lilja, Hans}},
issn = {{1078-0432}},
language = {{eng}},
month = {{09}},
number = {{17}},
pages = {{4374--4381}},
publisher = {{American Association for Cancer Research}},
series = {{Clinical Cancer Research}},
title = {{The relationship between prostate-specific antigen and prostate cancer risk : The prostate biopsy collaborative group}},
url = {{http://dx.doi.org/10.1158/1078-0432.CCR-10-1328}},
doi = {{10.1158/1078-0432.CCR-10-1328}},
volume = {{16}},
year = {{2010}},
}