Advanced

Restrictions on the interpretation of spinal reflex modulation in pain and analgesia research

Schomburg, E. D. ; Pertovaara, A. ; Duggan, A. E. ; Schouenborg, J. LU ; Carstens, E. and Schomburg, E. D. (1997) In Pain Forum 6(2). p.101-109
Abstract

The use of motor reactions including spinal motor mechanisms, such as tail-flick, hot plate test, and flexion reflexes, in research on pain and analgesia requires some precautions, and results should be interpreted with caution. Nocifensive specificity and analgesic selectivity cannot be established unequivocally by only comparing reflexes evoked by noxious stimuli with monosynaptic reflexes. Rather, it is necessary to compare the responses evoked by activating nociceptive and non-nociceptive flexor reflex afferent pathways and non-flexor reflex afferent pathways, preferably from different areas, if the effectiveness and selectivity of analgesic drugs or procedures are to be accurately assessed. In addition, monosynaptic reflexes to... (More)

The use of motor reactions including spinal motor mechanisms, such as tail-flick, hot plate test, and flexion reflexes, in research on pain and analgesia requires some precautions, and results should be interpreted with caution. Nocifensive specificity and analgesic selectivity cannot be established unequivocally by only comparing reflexes evoked by noxious stimuli with monosynaptic reflexes. Rather, it is necessary to compare the responses evoked by activating nociceptive and non-nociceptive flexor reflex afferent pathways and non-flexor reflex afferent pathways, preferably from different areas, if the effectiveness and selectivity of analgesic drugs or procedures are to be accurately assessed. In addition, monosynaptic reflexes to flexor and extensor muscles should be evaluated. This is of particular importance in animal experiments.

(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Flexor reflex afferents, Monoamines, Monosynaptic reflex, Nociception, Opioids
in
Pain Forum
volume
6
issue
2
pages
101 - 109
publisher
Elsevier
external identifiers
  • scopus:0030857205
ISSN
1058-9139
DOI
10.1016/S1082-3174(97)70008-4
language
English
LU publication?
no
id
b0823c87-2fb2-4f87-9c16-a9eded998f8a
date added to LUP
2019-06-25 16:07:32
date last changed
2020-01-13 02:07:08
@article{b0823c87-2fb2-4f87-9c16-a9eded998f8a,
  abstract     = {<p>The use of motor reactions including spinal motor mechanisms, such as tail-flick, hot plate test, and flexion reflexes, in research on pain and analgesia requires some precautions, and results should be interpreted with caution. Nocifensive specificity and analgesic selectivity cannot be established unequivocally by only comparing reflexes evoked by noxious stimuli with monosynaptic reflexes. Rather, it is necessary to compare the responses evoked by activating nociceptive and non-nociceptive flexor reflex afferent pathways and non-flexor reflex afferent pathways, preferably from different areas, if the effectiveness and selectivity of analgesic drugs or procedures are to be accurately assessed. In addition, monosynaptic reflexes to flexor and extensor muscles should be evaluated. This is of particular importance in animal experiments.</p>},
  author       = {Schomburg, E. D. and Pertovaara, A. and Duggan, A. E. and Schouenborg, J. and Carstens, E. and Schomburg, E. D.},
  issn         = {1058-9139},
  language     = {eng},
  number       = {2},
  pages        = {101--109},
  publisher    = {Elsevier},
  series       = {Pain Forum},
  title        = {Restrictions on the interpretation of spinal reflex modulation in pain and analgesia research},
  url          = {http://dx.doi.org/10.1016/S1082-3174(97)70008-4},
  doi          = {10.1016/S1082-3174(97)70008-4},
  volume       = {6},
  year         = {1997},
}