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Gene-Environment Interactions for Metals

Broberg, Karin LU orcid ; Engström, Karin LU and Ameer, Shegufta LU (2014) 1. p.239-264
Abstract

It has become increasingly clear that the individual genetic background influences susceptibility to metal toxicity. Genetic variation in genes that regulate metal toxicokinetics and toxicodynamics influence the degree of metal accumulation and retention in the body, as well as toxic effects. Moreover, factors that regulate gene expression, so-called epigenetic factors, have been identified as targets for metal toxicity. This chapter addresses what is currently known about such gene-environment interactions. The picture that emerges for most metals is that the genetic influence is probably not attributed to a single gene for each metal; rather it is polygenic, with some genes having a stronger effect than others. The presence of... (More)

It has become increasingly clear that the individual genetic background influences susceptibility to metal toxicity. Genetic variation in genes that regulate metal toxicokinetics and toxicodynamics influence the degree of metal accumulation and retention in the body, as well as toxic effects. Moreover, factors that regulate gene expression, so-called epigenetic factors, have been identified as targets for metal toxicity. This chapter addresses what is currently known about such gene-environment interactions. The picture that emerges for most metals is that the genetic influence is probably not attributed to a single gene for each metal; rather it is polygenic, with some genes having a stronger effect than others. The presence of variants of the human leukocyte antigen system and the risk of beryllium-related pulmonary disease was one of the first and maybe the strongest example of a gene-environment interaction. There are also clear gene-environment interactions for arsenic and lead. Evidence is rapidly growing for epigenetic effects of metals, e.g. for arsenic, cadmium, and lead, which may explain the association between metal exposure early in life and toxic effects later in life, as well as metal carcinogenicity.

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Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Copy number variation, DNA methylation, Effect modification, Epigenetic, Histone modification, MicroRNA, Polymorphisms SNP, Susceptibility
host publication
Handbook on the Toxicology of Metals
editor
Nordberg, Gunnar ; Fowler, Bruce and Nordberg, Monica
volume
1
edition
4th
pages
239 - 264
publisher
Elsevier
external identifiers
  • scopus:84943557847
ISBN
9780123973399
9780444594532
DOI
10.1016/B978-0-444-59453-2.00012-3
language
English
LU publication?
yes
id
b0ce19ae-78c6-432d-bb93-176a679bfb8d
date added to LUP
2019-02-14 12:10:55
date last changed
2021-11-10 11:38:53
@inbook{b0ce19ae-78c6-432d-bb93-176a679bfb8d,
  abstract     = {<p>It has become increasingly clear that the individual genetic background influences susceptibility to metal toxicity. Genetic variation in genes that regulate metal toxicokinetics and toxicodynamics influence the degree of metal accumulation and retention in the body, as well as toxic effects. Moreover, factors that regulate gene expression, so-called epigenetic factors, have been identified as targets for metal toxicity. This chapter addresses what is currently known about such gene-environment interactions. The picture that emerges for most metals is that the genetic influence is probably not attributed to a single gene for each metal; rather it is polygenic, with some genes having a stronger effect than others. The presence of variants of the human leukocyte antigen system and the risk of beryllium-related pulmonary disease was one of the first and maybe the strongest example of a gene-environment interaction. There are also clear gene-environment interactions for arsenic and lead. Evidence is rapidly growing for epigenetic effects of metals, e.g. for arsenic, cadmium, and lead, which may explain the association between metal exposure early in life and toxic effects later in life, as well as metal carcinogenicity.</p>},
  author       = {Broberg, Karin and Engström, Karin and Ameer, Shegufta},
  booktitle    = {Handbook on the Toxicology of Metals},
  editor       = {Nordberg, Gunnar and Fowler, Bruce and Nordberg, Monica},
  isbn         = {9780123973399},
  language     = {eng},
  month        = {10},
  pages        = {239--264},
  publisher    = {Elsevier},
  title        = {Gene-Environment Interactions for Metals},
  url          = {http://dx.doi.org/10.1016/B978-0-444-59453-2.00012-3},
  doi          = {10.1016/B978-0-444-59453-2.00012-3},
  volume       = {1},
  year         = {2014},
}