Galectin-8 inhibition and functions in immune response and tumor biology
(2024) In Medicinal Research Reviews- Abstract
Galectins are among organisms' most abundantly expressed lectins (carbohydrate-binding proteins) that specifically bind β-galactosides. They act not only outside the cell, where they bind to extracellular matrix glycans, but also inside the cell, where they have a significant impact on signaling pathways. Galectin-8 is a galectin family protein encoded by the LGALS8 gene. Its role is evident in both T- and B-cell immunity and in the innate immune response, where it acts directly on dendritic cells and induces some pro-inflammatory cytokines. Galectin-8 also plays an important role in the defense against bacterial and viral infections. It is known to promote antibacterial autophagy by recognizing and binding glycans present on the... (More)
Galectins are among organisms' most abundantly expressed lectins (carbohydrate-binding proteins) that specifically bind β-galactosides. They act not only outside the cell, where they bind to extracellular matrix glycans, but also inside the cell, where they have a significant impact on signaling pathways. Galectin-8 is a galectin family protein encoded by the LGALS8 gene. Its role is evident in both T- and B-cell immunity and in the innate immune response, where it acts directly on dendritic cells and induces some pro-inflammatory cytokines. Galectin-8 also plays an important role in the defense against bacterial and viral infections. It is known to promote antibacterial autophagy by recognizing and binding glycans present on the vacuolar membrane, thus acting as a danger receptor. The most important role of galectin-8 is the regulation of cancer growth, metastasis, tumor progression, and tumor cell survival. Importantly, the expression of galectins is typically higher in tumor tissues than in noncancerous tissues. In this review article, we focus on galectin-8 and its function in immune response, microbial infections, and cancer. Given all of these functions of galectin-8, we emphasize the importance of developing new and selective galectin-8 inhibitors and report the current status of their development.
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- author
- Purić, Edvin ; Nilsson, Ulf J. LU and Anderluh, Marko LU
- organization
- publishing date
- 2024-04-13
- type
- Contribution to journal
- publication status
- epub
- subject
- in
- Medicinal Research Reviews
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:38613488
- scopus:85190158425
- ISSN
- 1098-1128
- DOI
- 10.1002/med.22041
- language
- English
- LU publication?
- yes
- additional info
- © 2024 The Authors. Medicinal Research Reviews published by Wiley Periodicals LLC.
- id
- b0ecbdfd-7fc0-41bc-b5f9-e8952d734c94
- date added to LUP
- 2024-04-18 16:07:31
- date last changed
- 2024-06-15 10:55:22
@article{b0ecbdfd-7fc0-41bc-b5f9-e8952d734c94,
abstract = {{<p>Galectins are among organisms' most abundantly expressed lectins (carbohydrate-binding proteins) that specifically bind β-galactosides. They act not only outside the cell, where they bind to extracellular matrix glycans, but also inside the cell, where they have a significant impact on signaling pathways. Galectin-8 is a galectin family protein encoded by the <i>LGALS8 </i>gene. Its role is evident in both T- and B-cell immunity and in the innate immune response, where it acts directly on dendritic cells and induces some pro-inflammatory cytokines. Galectin-8 also plays an important role in the defense against bacterial and viral infections. It is known to promote antibacterial autophagy by recognizing and binding glycans present on the vacuolar membrane, thus acting as a danger receptor. The most important role of galectin-8 is the regulation of cancer growth, metastasis, tumor progression, and tumor cell survival. Importantly, the expression of galectins is typically higher in tumor tissues than in noncancerous tissues. In this review article, we focus on galectin-8 and its function in immune response, microbial infections, and cancer. Given all of these functions of galectin-8, we emphasize the importance of developing new and selective galectin-8 inhibitors and report the current status of their development.</p>}},
author = {{Purić, Edvin and Nilsson, Ulf J. and Anderluh, Marko}},
issn = {{1098-1128}},
language = {{eng}},
month = {{04}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Medicinal Research Reviews}},
title = {{Galectin-8 inhibition and functions in immune response and tumor biology}},
url = {{http://dx.doi.org/10.1002/med.22041}},
doi = {{10.1002/med.22041}},
year = {{2024}},
}