Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Morphological and hemodynamical alterations in brachial artery and cephalic vein. An image-based study for preoperative assessment for vascular access creation

Aristokleous, Nicolas LU orcid ; Houston, J Graeme ; Browne, Leonard D ; Broderick, Stephen P ; Kokkalis, Efstratios ; Gandy, Stephen J and Walsh, Michael T (2018) In International Journal for Numerical Methods in Biomedical Engineering 34(11). p.3136-3136
Abstract

The current study aims to computationally evaluate the effect of right upper arm position on the geometric and hemodynamic characteristics of the brachial artery (BA) and cephalic vein (CV) and, furthermore, to present in detail the methodology to characterise morphological and hemodynamical healthy vessels. Ten healthy volunteers were analysed in two configurations, the supine (S) and the prone (P) position. Lumen 3D surface models were constructed from images acquired from a non-contrast MRI sequence. Then, the models were used to numerically compute the physiological range of geometric (n = 10) and hemodynamic (n = 3) parameters in the BA and CV. Geometric parameters such as curvature and tortuosity, and hemodynamic parameters based... (More)

The current study aims to computationally evaluate the effect of right upper arm position on the geometric and hemodynamic characteristics of the brachial artery (BA) and cephalic vein (CV) and, furthermore, to present in detail the methodology to characterise morphological and hemodynamical healthy vessels. Ten healthy volunteers were analysed in two configurations, the supine (S) and the prone (P) position. Lumen 3D surface models were constructed from images acquired from a non-contrast MRI sequence. Then, the models were used to numerically compute the physiological range of geometric (n = 10) and hemodynamic (n = 3) parameters in the BA and CV. Geometric parameters such as curvature and tortuosity, and hemodynamic parameters based on wall shear stress (WSS) metrics were calculated with the use of computational fluid dynamics. Our results highlight that changes in arm position had a greater impact on WSS metrics of the BA by altering the mean and maximum blood flow rate of the vessel. Whereas, curvature and tortuosity were found not to be significantly different between positions. Inter-variability was associated with antegrade and retrograde flow in BA, and antegrade flow in CV. Shear stress was low and oscillatory shear forces were negligible. This data suggests that deviations from this state may contribute to the risk of accelerated intimal hyperplasia of the vein in arteriovenous fistulas. Therefore, preoperative conditions coupled with post-operative longitudinal data will aid the identification of such relationships.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal for Numerical Methods in Biomedical Engineering
volume
34
issue
11
pages
3136 - 3136
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:30070048
  • scopus:85053283087
ISSN
2040-7947
DOI
10.1002/cnm.3136
language
English
LU publication?
no
additional info
© 2018 John Wiley & Sons, Ltd.
id
b0f70d71-7cf3-439c-beee-f33424cd44a7
date added to LUP
2019-05-14 09:29:33
date last changed
2024-03-19 07:15:31
@article{b0f70d71-7cf3-439c-beee-f33424cd44a7,
  abstract     = {{<p>The current study aims to computationally evaluate the effect of right upper arm position on the geometric and hemodynamic characteristics of the brachial artery (BA) and cephalic vein (CV) and, furthermore, to present in detail the methodology to characterise morphological and hemodynamical healthy vessels. Ten healthy volunteers were analysed in two configurations, the supine (S) and the prone (P) position. Lumen 3D surface models were constructed from images acquired from a non-contrast MRI sequence. Then, the models were used to numerically compute the physiological range of geometric (n = 10) and hemodynamic (n = 3) parameters in the BA and CV. Geometric parameters such as curvature and tortuosity, and hemodynamic parameters based on wall shear stress (WSS) metrics were calculated with the use of computational fluid dynamics. Our results highlight that changes in arm position had a greater impact on WSS metrics of the BA by altering the mean and maximum blood flow rate of the vessel. Whereas, curvature and tortuosity were found not to be significantly different between positions. Inter-variability was associated with antegrade and retrograde flow in BA, and antegrade flow in CV. Shear stress was low and oscillatory shear forces were negligible. This data suggests that deviations from this state may contribute to the risk of accelerated intimal hyperplasia of the vein in arteriovenous fistulas. Therefore, preoperative conditions coupled with post-operative longitudinal data will aid the identification of such relationships.</p>}},
  author       = {{Aristokleous, Nicolas and Houston, J Graeme and Browne, Leonard D and Broderick, Stephen P and Kokkalis, Efstratios and Gandy, Stephen J and Walsh, Michael T}},
  issn         = {{2040-7947}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{3136--3136}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal for Numerical Methods in Biomedical Engineering}},
  title        = {{Morphological and hemodynamical alterations in brachial artery and cephalic vein. An image-based study for preoperative assessment for vascular access creation}},
  url          = {{http://dx.doi.org/10.1002/cnm.3136}},
  doi          = {{10.1002/cnm.3136}},
  volume       = {{34}},
  year         = {{2018}},
}